Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever

Detalhes bibliográficos
Autor(a) principal: Martins, Flaviano dos Santos
Data de Publicação: 2011
Outros Autores: Andrade, Samir de Deus Elian, Vieira, Angelica Thomaz, Tiago, Fabiana da Conceição Pereira, Martins, Ariane Katiuscia dos Santos, Silva, Flávia Cristina de Paula e, Souza, Éricka Lorenna de Sales e, Sousa, Lirlândia Pires de, Araújo, Helena Rocha Corrêa de, Pimenta, Paulo Filemon Paolucci, Bonjardim, Claudio Antonio, Arantes, Rosa Maria Esteves, Teixeira, Mauro Martins, Nicoli, Jacques Robert
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1016/j.ijmm.2010.11.002
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8925
Resumo: Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil
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spelling Martins, Flaviano dos SantosAndrade, Samir de Deus ElianVieira, Angelica ThomazTiago, Fabiana da Conceição PereiraMartins, Ariane Katiuscia dos SantosSilva, Flávia Cristina de Paula eSouza, Éricka Lorenna de Sales eSousa, Lirlândia Pires deAraújo, Helena Rocha Corrêa dePimenta, Paulo Filemon PaolucciBonjardim, Claudio AntonioArantes, Rosa Maria EstevesTeixeira, Mauro MartinsNicoli, Jacques Robert2014-11-20T16:23:31Z2014-11-20T16:23:31Z2011MARTINS, Flaviano dos Santos et al. Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever. International Journal of Medical Microbiology, v. 301, n.4, p. 359-364, 2011.1438-4221https://www.arca.fiocruz.br/handle/icict/892510.1016/j.ijmm.2010.11.002engUrban & FischerOral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid feverinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Laboratório de Entomologia Médica. Centro de Pesquisa René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Laboratório de Entomologia Médica. Centro de Pesquisa René Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilSalmonella spp. is Gram-negative, facultative, intracellular pathogens that cause several diarrheal diseases ranging from self-limiting gastroenteritis to typhoid fever. Previous results from our laboratory showed that Saccharomyces cerevisiae strain UFMG 905 isolated from ‘cachaça’ production presented probiotic properties due to its ability to protect against experimental infection with Salmonella entericaserovar Typhimurium. In this study, the effects of oral treatment with S. cerevisiae 905 were evaluated at the immunological level in a murine model of typhoid fever. Treatment with S. cerevisiae 905 inhibited weight loss and increased survival rate after Salmonella challenge. Immunological data demonstrated that S. cerevisiae 905 decreased levels of proinflammatory cytokines and modulated the activation of mitogen-activated protein kinases (p38 and JNK, but not ERK1/2), NF-κB and AP-1, signaling pathways which are involved in the transcriptional activation of proinflammatory mediators. Experiments in germ-free mice revealed that probiotic effects were due, at least in part, to the binding of Salmonella to the yeast. In conclusion, S. cerevisiae 905 acts as a potential new biotherapy against S. Typhimurium infection due to its ability to bind bacteria and modulate signaling pathways involved in the activation of inflammation in a murine model of typhoid fever.ProbioticsSaccharomyces cerevisiaeSalmonella enterica serovar TyphimuriumCytokinesMAP kinasesNF-κBAP-1info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8925/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALOral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever.pdfOral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever.pdfapplication/pdf780476https://www.arca.fiocruz.br/bitstream/icict/8925/2/Oral%20treatment%20with%20Saccharomyces%20cerevisiae%20strain%20UFMG%20905%20modulates%20immune%20responses%20and%20interferes%20with%20signal%20pathways%20involved%20in%20the%20activation%20of%20inflammation%20in%20a%20murine%20model%20of%20typhoid%20fever.pdfba9fa42b33aada83e00b02a67f2d9372MD52TEXTOral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever.pdf.txtOral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever.pdf.txtExtracted texttext/plain35787https://www.arca.fiocruz.br/bitstream/icict/8925/3/Oral%20treatment%20with%20Saccharomyces%20cerevisiae%20strain%20UFMG%20905%20modulates%20immune%20responses%20and%20interferes%20with%20signal%20pathways%20involved%20in%20the%20activation%20of%20inflammation%20in%20a%20murine%20model%20of%20typhoid%20fever.pdf.txtaa2f26c2ff7eb18c99bf5005b197234cMD53icict/89252019-06-19 10:12:51.642oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:12:51Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever
title Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever
spellingShingle Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever
Martins, Flaviano dos Santos
Probiotics
Saccharomyces cerevisiae
Salmonella enterica serovar Typhimurium
Cytokines
MAP kinases
NF-κB
AP-1
title_short Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever
title_full Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever
title_fullStr Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever
title_full_unstemmed Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever
title_sort Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever
author Martins, Flaviano dos Santos
author_facet Martins, Flaviano dos Santos
Andrade, Samir de Deus Elian
Vieira, Angelica Thomaz
Tiago, Fabiana da Conceição Pereira
Martins, Ariane Katiuscia dos Santos
Silva, Flávia Cristina de Paula e
Souza, Éricka Lorenna de Sales e
Sousa, Lirlândia Pires de
Araújo, Helena Rocha Corrêa de
Pimenta, Paulo Filemon Paolucci
Bonjardim, Claudio Antonio
Arantes, Rosa Maria Esteves
Teixeira, Mauro Martins
Nicoli, Jacques Robert
author_role author
author2 Andrade, Samir de Deus Elian
Vieira, Angelica Thomaz
Tiago, Fabiana da Conceição Pereira
Martins, Ariane Katiuscia dos Santos
Silva, Flávia Cristina de Paula e
Souza, Éricka Lorenna de Sales e
Sousa, Lirlândia Pires de
Araújo, Helena Rocha Corrêa de
Pimenta, Paulo Filemon Paolucci
Bonjardim, Claudio Antonio
Arantes, Rosa Maria Esteves
Teixeira, Mauro Martins
Nicoli, Jacques Robert
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Martins, Flaviano dos Santos
Andrade, Samir de Deus Elian
Vieira, Angelica Thomaz
Tiago, Fabiana da Conceição Pereira
Martins, Ariane Katiuscia dos Santos
Silva, Flávia Cristina de Paula e
Souza, Éricka Lorenna de Sales e
Sousa, Lirlândia Pires de
Araújo, Helena Rocha Corrêa de
Pimenta, Paulo Filemon Paolucci
Bonjardim, Claudio Antonio
Arantes, Rosa Maria Esteves
Teixeira, Mauro Martins
Nicoli, Jacques Robert
dc.subject.en.pt_BR.fl_str_mv Probiotics
Saccharomyces cerevisiae
Salmonella enterica serovar Typhimurium
Cytokines
MAP kinases
NF-κB
AP-1
topic Probiotics
Saccharomyces cerevisiae
Salmonella enterica serovar Typhimurium
Cytokines
MAP kinases
NF-κB
AP-1
description Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-11-20T16:23:31Z
dc.date.available.fl_str_mv 2014-11-20T16:23:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv MARTINS, Flaviano dos Santos et al. Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever. International Journal of Medical Microbiology, v. 301, n.4, p. 359-364, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8925
dc.identifier.issn.none.fl_str_mv 1438-4221
dc.identifier.doi.none.fl_str_mv 10.1016/j.ijmm.2010.11.002
identifier_str_mv MARTINS, Flaviano dos Santos et al. Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever. International Journal of Medical Microbiology, v. 301, n.4, p. 359-364, 2011.
1438-4221
10.1016/j.ijmm.2010.11.002
url https://www.arca.fiocruz.br/handle/icict/8925
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Urban & Fischer
publisher.none.fl_str_mv Urban & Fischer
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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