Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice.
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/30739 |
Resumo: | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil |
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Martins, Flaviano dos SantosVieira, Angélica ThomazElian, Samir de DeusArantes, Rosa Maria EstevesTiago, Fabiana da Conceição PereiraSousa, Lirlândia Pires deAraújo, Helena R.C.Pimenta, Paulo Filemon PaolucciBonjardim, Cláudio AntonioNicoli, Jacques RobertTeixeira, Mauro Martins2018-12-21T18:27:26Z2018-12-21T18:27:26Z2013MARTINS, Flaviano dos Santos et al. Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice. Microbes Infect., v. 15, n. 4, p. 270-279, 20131286-4579https://www.arca.fiocruz.br/handle/icict/3073910.1016/j.micinf.2012.12.007engElsevierSaccharomyces boulardiiSalmonella enterica serovar Typhimuriumtranslocação bacterianacitocinasSaccharomyces boulardiiSalmonella enterica serovar TyphimuriumBacterial translocationCytokinesMitogen-activated protein kinasesInhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilFaculdade de Fármacia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilGrowing evidences suggest that Saccharomyces boulardii (SB) is efficacious against bacterial infections and inflammatory bowel diseases. This study investigated the effects of treatment with SB provided in a murine model of typhoid fever. Mice were divided into two groups: (1) control animals challenged with Salmonella Typhimurium (ST), and (2) animals receiving SB, and then challenged with ST. At days 0, 1, 5, 10 and 15 post-challenge, animals were euthanized and tissues collected to analyze bacterial translocation, cytokines, signaling pathways and histological analysis. Survival rate and animal weight were also evaluated. Treatment with SB increased survival rate and inhibited translocation of bacteria after ST challenge. Histological data showed that SB also protected mice against liver damage induced by ST. SB decreased levels of inflammatory cytokines and activation of mitogen-activated protein kinases (p38, JNK and ERK1/2), phospho-IκB, p65-RelA, phospho-jun and c-fos in the colon, signal pathways involved in the activation of inflammation induced by ST. Further experiments revealed that probiotic effects were due, at least in part, to the binding of ST to the yeast. Such binding diminishes ST translocation, resulting in decreased activation of signaling pathways which lead to intestinal inflammation in a murine model of typhoid fever.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/30739/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALInhibition of tissue inflammation and bacterial translocation.pdfInhibition of tissue inflammation and bacterial translocation.pdfapplication/pdf5745525https://www.arca.fiocruz.br/bitstream/icict/30739/2/Inhibition%20of%20tissue%20inflammation%20and%20bacterial%20translocation.pdf20ce864a4910ae14276121be266f2f73MD52TEXTInhibition of tissue inflammation and bacterial translocation.pdf.txtInhibition of tissue inflammation and bacterial translocation.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice. |
title |
Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice. |
spellingShingle |
Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice. Martins, Flaviano dos Santos Saccharomyces boulardii Salmonella enterica serovar Typhimurium translocação bacteriana citocinas Saccharomyces boulardii Salmonella enterica serovar Typhimurium Bacterial translocation Cytokines Mitogen-activated protein kinases |
title_short |
Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice. |
title_full |
Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice. |
title_fullStr |
Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice. |
title_full_unstemmed |
Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice. |
title_sort |
Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice. |
author |
Martins, Flaviano dos Santos |
author_facet |
Martins, Flaviano dos Santos Vieira, Angélica Thomaz Elian, Samir de Deus Arantes, Rosa Maria Esteves Tiago, Fabiana da Conceição Pereira Sousa, Lirlândia Pires de Araújo, Helena R.C. Pimenta, Paulo Filemon Paolucci Bonjardim, Cláudio Antonio Nicoli, Jacques Robert Teixeira, Mauro Martins |
author_role |
author |
author2 |
Vieira, Angélica Thomaz Elian, Samir de Deus Arantes, Rosa Maria Esteves Tiago, Fabiana da Conceição Pereira Sousa, Lirlândia Pires de Araújo, Helena R.C. Pimenta, Paulo Filemon Paolucci Bonjardim, Cláudio Antonio Nicoli, Jacques Robert Teixeira, Mauro Martins |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Martins, Flaviano dos Santos Vieira, Angélica Thomaz Elian, Samir de Deus Arantes, Rosa Maria Esteves Tiago, Fabiana da Conceição Pereira Sousa, Lirlândia Pires de Araújo, Helena R.C. Pimenta, Paulo Filemon Paolucci Bonjardim, Cláudio Antonio Nicoli, Jacques Robert Teixeira, Mauro Martins |
dc.subject.other.pt_BR.fl_str_mv |
Saccharomyces boulardii Salmonella enterica serovar Typhimurium translocação bacteriana citocinas |
topic |
Saccharomyces boulardii Salmonella enterica serovar Typhimurium translocação bacteriana citocinas Saccharomyces boulardii Salmonella enterica serovar Typhimurium Bacterial translocation Cytokines Mitogen-activated protein kinases |
dc.subject.en.pt_BR.fl_str_mv |
Saccharomyces boulardii Salmonella enterica serovar Typhimurium Bacterial translocation Cytokines Mitogen-activated protein kinases |
description |
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2018-12-21T18:27:26Z |
dc.date.available.fl_str_mv |
2018-12-21T18:27:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MARTINS, Flaviano dos Santos et al. Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice. Microbes Infect., v. 15, n. 4, p. 270-279, 2013 |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/30739 |
dc.identifier.issn.pt_BR.fl_str_mv |
1286-4579 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.micinf.2012.12.007 |
identifier_str_mv |
MARTINS, Flaviano dos Santos et al. Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice. Microbes Infect., v. 15, n. 4, p. 270-279, 2013 1286-4579 10.1016/j.micinf.2012.12.007 |
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https://www.arca.fiocruz.br/handle/icict/30739 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Elsevier |
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Elsevier |
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