Modeling autism spectrum disorders with induced pluripotent stem cell-derived brain organoids

Detalhes bibliográficos
Autor(a) principal: Santos, John Lenon de Souza
Data de Publicação: 2023
Outros Autores: Araújo, Cecília de Almeida, Rocha, Clarissa Araújo Gurgel, Costa-Ferro, Zaquer Suzana Munhoz, Souza, Bruno Solano de Freitas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/59046
Resumo: Fundação Maria Emília (FME). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
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spelling Santos, John Lenon de SouzaAraújo, Cecília de AlmeidaRocha, Clarissa Araújo GurgelCosta-Ferro, Zaquer Suzana MunhozSouza, Bruno Solano de Freitas2023-06-15T16:50:33Z2023-06-15T16:50:33Z2023SANTOS, John Lenon de Souza et al. Modeling autism spectrum disorders with induced pluripotent stem cell-derived brain organoids. Biomolecules, v. 13, n. 260, p. 1-16, 2023.2218-273Xhttps://www.arca.fiocruz.br/handle/icict/5904610.3390/biom13020260Fundação Maria Emília (FME). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil.Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Instituto de Pesquisa e Ensino D'OR. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Instituto de Pesquisa e Ensino D'OR. Salvador, BA, Brasil.Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Instituto de Pesquisa e Ensino D'OR. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Instituto de Pesquisa e Ensino D'OR. Salvador, BA, Brasil.Autism spectrum disorders (ASD) are a group of complex neurodevelopmental disorders that affect communication and social interactions and present with restricted interests and repetitive behavior patterns. The susceptibility to ASD is strongly influenced by genetic/heritable factors; however, there is still a large gap in understanding the cellular and molecular mechanisms underlying the neurobiology of ASD. Significant progress has been made in identifying ASD risk genes and the possible convergent pathways regulated by these gene networks during development. The breakthrough of cellular reprogramming technology has allowed the generation of induced pluripotent stem cells (iPSCs) from individuals with syndromic and idiopathic ASD, providing patient-specific cell models for mechanistic studies. In the past decade, protocols for developing brain organoids from these cells have been established, leading to significant advances in the in vitro reproducibility of the early steps of human brain development. Here, we reviewed the most relevant literature regarding the application of brain organoids to the study of ASD, providing the current state of the art, and discussing the impact of such models on the field, limitations, and opportunities for future development.engMDPITranstorno do espectro autistaOrganoides cerebraisCélula-tronco pluripotenteAutism spectrum disorderBrain organoidsPluripotent stem cellTranstorno do Espectro AutistaOrganoidesCélulas-Tronco Pluripotentes InduzidasModeling autism spectrum disorders with induced pluripotent stem cell-derived brain organoidsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/59046/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSantos, J. Modeling Autism Spectrum Disorders....pdfSantos, J. Modeling Autism Spectrum Disorders....pdfapplication/pdf7388446https://www.arca.fiocruz.br/bitstream/icict/59046/2/Santos%2c%20J.%20Modeling%20Autism%20Spectrum%20Disorders....pdfdad28d4cc6b9a2206055431da44b3923MD52icict/590462023-06-15 21:00:35.532oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-06-16T00:00:35Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Modeling autism spectrum disorders with induced pluripotent stem cell-derived brain organoids
title Modeling autism spectrum disorders with induced pluripotent stem cell-derived brain organoids
spellingShingle Modeling autism spectrum disorders with induced pluripotent stem cell-derived brain organoids
Santos, John Lenon de Souza
Transtorno do espectro autista
Organoides cerebrais
Célula-tronco pluripotente
Autism spectrum disorder
Brain organoids
Pluripotent stem cell
Transtorno do Espectro Autista
Organoides
Células-Tronco Pluripotentes Induzidas
title_short Modeling autism spectrum disorders with induced pluripotent stem cell-derived brain organoids
title_full Modeling autism spectrum disorders with induced pluripotent stem cell-derived brain organoids
title_fullStr Modeling autism spectrum disorders with induced pluripotent stem cell-derived brain organoids
title_full_unstemmed Modeling autism spectrum disorders with induced pluripotent stem cell-derived brain organoids
title_sort Modeling autism spectrum disorders with induced pluripotent stem cell-derived brain organoids
author Santos, John Lenon de Souza
author_facet Santos, John Lenon de Souza
Araújo, Cecília de Almeida
Rocha, Clarissa Araújo Gurgel
Costa-Ferro, Zaquer Suzana Munhoz
Souza, Bruno Solano de Freitas
author_role author
author2 Araújo, Cecília de Almeida
Rocha, Clarissa Araújo Gurgel
Costa-Ferro, Zaquer Suzana Munhoz
Souza, Bruno Solano de Freitas
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Santos, John Lenon de Souza
Araújo, Cecília de Almeida
Rocha, Clarissa Araújo Gurgel
Costa-Ferro, Zaquer Suzana Munhoz
Souza, Bruno Solano de Freitas
dc.subject.other.en_US.fl_str_mv Transtorno do espectro autista
Organoides cerebrais
Célula-tronco pluripotente
topic Transtorno do espectro autista
Organoides cerebrais
Célula-tronco pluripotente
Autism spectrum disorder
Brain organoids
Pluripotent stem cell
Transtorno do Espectro Autista
Organoides
Células-Tronco Pluripotentes Induzidas
dc.subject.en.en_US.fl_str_mv Autism spectrum disorder
Brain organoids
Pluripotent stem cell
dc.subject.decs.en_US.fl_str_mv Transtorno do Espectro Autista
Organoides
Células-Tronco Pluripotentes Induzidas
description Fundação Maria Emília (FME). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-06-15T16:50:33Z
dc.date.available.fl_str_mv 2023-06-15T16:50:33Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, John Lenon de Souza et al. Modeling autism spectrum disorders with induced pluripotent stem cell-derived brain organoids. Biomolecules, v. 13, n. 260, p. 1-16, 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/59046
dc.identifier.issn.en_US.fl_str_mv 2218-273X
dc.identifier.doi.none.fl_str_mv 10.3390/biom13020260
identifier_str_mv SANTOS, John Lenon de Souza et al. Modeling autism spectrum disorders with induced pluripotent stem cell-derived brain organoids. Biomolecules, v. 13, n. 260, p. 1-16, 2023.
2218-273X
10.3390/biom13020260
url https://www.arca.fiocruz.br/handle/icict/59046
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/59046/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/59046/2/Santos%2c%20J.%20Modeling%20Autism%20Spectrum%20Disorders....pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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