Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids – a review

Detalhes bibliográficos
Autor(a) principal: Silva, Ana Paula B.
Data de Publicação: 2014
Outros Autores: Santos, Joselita Maria M, Martins, Ademir J
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10401
Resumo: Instituto Nacional de Pesquisas da Amazônia. Laboratório de Malária e Dengue. Manaus, AM, Brasil.
id CRUZ_0859b2da0c78e2131666057a0d2ed89d
oai_identifier_str oai:www.arca.fiocruz.br:icict/10401
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Silva, Ana Paula B.Santos, Joselita Maria MMartins, Ademir J2015-05-19T13:26:05Z2015-05-19T13:26:05Z2014SILVA, Ana Paula B.; SANTOS, Joselita Maria M.; MARTINS, Ademir J. Parasites & Vectors, 2014, v.7:450, 14p, 2014.1756-3305https://www.arca.fiocruz.br/handle/icict/1040110.1186/1756-3305-7-450engBioMed CentralMaláriaPiretrinasAnophelesSodium channelMalariaPyrethroidsResistancekdrPiretrinasMalariaMutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids – a reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Nacional de Pesquisas da Amazônia. Laboratório de Malária e Dengue. Manaus, AM, Brasil.Instituto Nacional de Pesquisas da Amazônia. Laboratório de Malária e Dengue. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil / 3Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, Brasil..Constant and extensive use of chemical insecticides has created a selection pressure and favored resistance development in many insect species worldwide. One of the most important pyrethroid resistance mechanisms is classified as target site insensitivity, due to conformational changes in the target site that impair a proper binding of the insecticide molecule. The voltage-gated sodium channel (NaV) is the target of pyrethroids and DDT insecticides, used to control insects of medical, agricultural and veterinary importance, such as anophelines. It has been reported that the presence of a few non-silent point mutations in the NaV gene are associated with pyrethroid resistance, termed as ‘kdr’ (knockdown resistance) for preventing the knockdown effect of these insecticides. The presence of these mutations, as well as their effects, has been thoroughly studied in Anopheles mosquitoes. So far, kdr mutations have already been detected in at least 13 species (Anopheles gambiae, Anopheles arabiensis, Anopheles sinensis, Anopheles stephensi, Anopheles subpictus, Anopheles sacharovi, Anopheles culicifacies, Anopheles sundaicus, Anopheles aconitus, Anopheles vagus, Anopheles paraliae, Anopheles peditaeniatus and Anopheles albimanus) from populations of African, Asian and, more recently, American continents. Seven mutational variants (L1014F, L1014S, L1014C, L1014W, N1013S, N1575Y and V1010L) were described, with the highest prevalence of L1014F, which occurs at the 1014 site in NaV IIS6 domain. The increase of frequency and distribution of kdr mutations clearly shows the importance of this mechanism in the process of pyrethroid resistance. In this sense, several species-specific and highly sensitive methods have been designed in order to genotype individual mosquitoes for kdr in large scale, which may serve as important tolls for monitoring the dynamics of pyrethroid resistance in natural populations. We also briefly discuss investigations concerning the course of Plasmodium infection in kdr individuals. Considering the limitation of insecticides available for employment in public health campaigns and the absence of a vaccine able to brake the life cycle of the malaria parasites, the use of pyrethroids is likely to remain as the main strategy against mosquitoes by either indoor residual spraying (IR) and insecticide treated nets (ITN). Therefore, monitoring insecticide resistance programs is a crucial need in malaria endemic countries.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10401/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALademir_martins2etal_IOC_2014.pdfapplication/pdf478540https://www.arca.fiocruz.br/bitstream/icict/10401/2/ademir_martins2etal_IOC_2014.pdf300a36c023bfea0251a5d6c818c42269MD52TEXTademir_martins2etal_IOC_2014.pdf.txtademir_martins2etal_IOC_2014.pdf.txtExtracted texttext/plain81670https://www.arca.fiocruz.br/bitstream/icict/10401/3/ademir_martins2etal_IOC_2014.pdf.txte28cdcbc8613fcb4641c60e2d2c7113bMD53icict/104012022-06-24 13:10:55.238oai:www.arca.fiocruz.br:icict/10401TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:10:55Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids – a review
title Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids – a review
spellingShingle Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids – a review
Silva, Ana Paula B.
Malária
Piretrinas
Anopheles
Sodium channel
Malaria
Pyrethroids
Resistance
kdr
Piretrinas
Malaria
title_short Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids – a review
title_full Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids – a review
title_fullStr Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids – a review
title_full_unstemmed Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids – a review
title_sort Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids – a review
author Silva, Ana Paula B.
author_facet Silva, Ana Paula B.
Santos, Joselita Maria M
Martins, Ademir J
author_role author
author2 Santos, Joselita Maria M
Martins, Ademir J
author2_role author
author
dc.contributor.author.fl_str_mv Silva, Ana Paula B.
Santos, Joselita Maria M
Martins, Ademir J
dc.subject.other.pt_BR.fl_str_mv Malária
Piretrinas
topic Malária
Piretrinas
Anopheles
Sodium channel
Malaria
Pyrethroids
Resistance
kdr
Piretrinas
Malaria
dc.subject.en.pt_BR.fl_str_mv Anopheles
Sodium channel
Malaria
Pyrethroids
Resistance
kdr
dc.subject.es.pt_BR.fl_str_mv Piretrinas
Malaria
description Instituto Nacional de Pesquisas da Amazônia. Laboratório de Malária e Dengue. Manaus, AM, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-05-19T13:26:05Z
dc.date.available.fl_str_mv 2015-05-19T13:26:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Ana Paula B.; SANTOS, Joselita Maria M.; MARTINS, Ademir J. Parasites & Vectors, 2014, v.7:450, 14p, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10401
dc.identifier.issn.pt_BR.fl_str_mv 1756-3305
dc.identifier.doi.pt_BR.fl_str_mv 10.1186/1756-3305-7-450
identifier_str_mv SILVA, Ana Paula B.; SANTOS, Joselita Maria M.; MARTINS, Ademir J. Parasites & Vectors, 2014, v.7:450, 14p, 2014.
1756-3305
10.1186/1756-3305-7-450
url https://www.arca.fiocruz.br/handle/icict/10401
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/10401/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/10401/2/ademir_martins2etal_IOC_2014.pdf
https://www.arca.fiocruz.br/bitstream/icict/10401/3/ademir_martins2etal_IOC_2014.pdf.txt
bitstream.checksum.fl_str_mv 7d48279ffeed55da8dfe2f8e81f3b81f
300a36c023bfea0251a5d6c818c42269
e28cdcbc8613fcb4641c60e2d2c7113b
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009251244703744

Registros relacionados