Human Papillomavirus types distribution among women with cervical preneoplastic, lesions and cancer in Luanda, Angola

Detalhes bibliográficos
Autor(a) principal: Damião, Paciência de Almeida
Data de Publicação: 2016
Outros Autores: Silva, Michelle Oliveira, Moreira, Miguel Ângelo, Poliakova, Natalia, Lima, Maria Emilia R. T. de, Chiovo, José, Nicol, Alcina Frederica
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16523
Resumo: Instituto Superior. Hospital MIlitar Prncipal. Departamento de Anatomia Patológica. Luanda, Angola.
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spelling Damião, Paciência de AlmeidaSilva, Michelle OliveiraMoreira, Miguel ÂngeloPoliakova, NataliaLima, Maria Emilia R. T. deChiovo, JoséNicol, Alcina Frederica2016-12-13T15:43:26Z2016-12-13T15:43:26Z2016DAMIÃO, Paciência de Almeida; et al. Human Papillomavirus types distribution among women with cervical preneoplastic, lesions and cancer in Luanda, Angola. Pan African Medical Journal, v. 24, n.268, 5p, 2016.1937-8688https://www.arca.fiocruz.br/handle/icict/1652310.11604/pamj.2016.24.268.9678engAFNETPapilomavírus HumanoCâncer cervicalLesõesCâncerAngolaSaúde da mulherHuman Papillomaviruscervical preneoplasticlesionscancerAngolawomens healthHuman Papillomavirus types distribution among women with cervical preneoplastic, lesions and cancer in Luanda, Angolainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Superior. Hospital MIlitar Prncipal. Departamento de Anatomia Patológica. Luanda, Angola.Fundação Oswaldo Cruz, Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer. Divisão de Genética. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Câncer. Divisão de Genética. Rio de Janeiro, RJ, Brasil.Instituto Superior. Hospital MIlitar Prncipal. Departamento de Anatomia Patológica. Luanda, Angola.Instituto Superior. Hospital MIlitar Prncipal. Departamento de Anatomia Patológica. Luanda, Angola.Instituto Superior. Hospital MIlitar Prncipal. Departamento de Anatomia Patológica. Luanda, Angola.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisa Médica. Rio de Janeiro, RJ. Brasil.Introduction: Cervical cancer is the leading cause of cancer deaths among females in Angola and human papillomavirus (HPV) is the main risk factor for the development of pre-cancerous squamous intraepithelial lesions. The diversity and frequency of HPV types in Angola has yet to be reported. Aim: To determine the frequency of HPV among women with squamous intraepithelial lesions from women in Luanda, Angola. Methods: Study participants included women diagnosed with cytological abnormalities that voluntarily provided Pap smears (n = 64). Genomic DNA was extracted from the samples for use as templates in the PCR amplification of HPV sequences. PCR products were sequenced to determine HPV type. Results: HPV DNA was detected in 71.9% (46/64) in the samples. A higher diversity of HPV types was found in the cytological lesions, such as ASCUS and LSIL (HPV16, 6, 18, 31, 58, 66, 70 and 82, in order of frequency) than that detected for HSIL and SSC (HPV16, 18, 6 and 33). The most prevalent HPV type were: HPV16, HPV6 and HPV18. Conclusion: This is the first report on HPV type diversity and frequency in woman of Angola. The results suggest that large-scale studies across Africa would improve our understanding of interrelationship between HPV infections and cervical cancer. More directly, the identification of the HPV types most prevalent suggests that women in Angola would benefit from currently available HPV vaccines.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16523/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmichelle_silva_etal_IOC_2016.pdfmichelle_silva_etal_IOC_2016.pdfapplication/pdf175344https://www.arca.fiocruz.br/bitstream/icict/16523/2/michelle_silva_etal_IOC_2016.pdf94b230572f6525bf05c4a9da598d65c1MD52TEXTmichelle_silva_etal_IOC_2016.pdf.txtmichelle_silva_etal_IOC_2016.pdf.txtExtracted texttext/plain23276https://www.arca.fiocruz.br/bitstream/icict/16523/3/michelle_silva_etal_IOC_2016.pdf.txte3e1f5c65407ba2cc6deb3eb38068af9MD53icict/165232018-08-15 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dc.title.pt_BR.fl_str_mv Human Papillomavirus types distribution among women with cervical preneoplastic, lesions and cancer in Luanda, Angola
title Human Papillomavirus types distribution among women with cervical preneoplastic, lesions and cancer in Luanda, Angola
spellingShingle Human Papillomavirus types distribution among women with cervical preneoplastic, lesions and cancer in Luanda, Angola
Damião, Paciência de Almeida
Papilomavírus Humano
Câncer cervical
Lesões
Câncer
Angola
Saúde da mulher
Human Papillomavirus
cervical preneoplastic
lesions
cancer
Angola
womens health
title_short Human Papillomavirus types distribution among women with cervical preneoplastic, lesions and cancer in Luanda, Angola
title_full Human Papillomavirus types distribution among women with cervical preneoplastic, lesions and cancer in Luanda, Angola
title_fullStr Human Papillomavirus types distribution among women with cervical preneoplastic, lesions and cancer in Luanda, Angola
title_full_unstemmed Human Papillomavirus types distribution among women with cervical preneoplastic, lesions and cancer in Luanda, Angola
title_sort Human Papillomavirus types distribution among women with cervical preneoplastic, lesions and cancer in Luanda, Angola
author Damião, Paciência de Almeida
author_facet Damião, Paciência de Almeida
Silva, Michelle Oliveira
Moreira, Miguel Ângelo
Poliakova, Natalia
Lima, Maria Emilia R. T. de
Chiovo, José
Nicol, Alcina Frederica
author_role author
author2 Silva, Michelle Oliveira
Moreira, Miguel Ângelo
Poliakova, Natalia
Lima, Maria Emilia R. T. de
Chiovo, José
Nicol, Alcina Frederica
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Damião, Paciência de Almeida
Silva, Michelle Oliveira
Moreira, Miguel Ângelo
Poliakova, Natalia
Lima, Maria Emilia R. T. de
Chiovo, José
Nicol, Alcina Frederica
dc.subject.other.pt_BR.fl_str_mv Papilomavírus Humano
Câncer cervical
Lesões
Câncer
Angola
Saúde da mulher
topic Papilomavírus Humano
Câncer cervical
Lesões
Câncer
Angola
Saúde da mulher
Human Papillomavirus
cervical preneoplastic
lesions
cancer
Angola
womens health
dc.subject.en.pt_BR.fl_str_mv Human Papillomavirus
cervical preneoplastic
lesions
cancer
Angola
womens health
description Instituto Superior. Hospital MIlitar Prncipal. Departamento de Anatomia Patológica. Luanda, Angola.
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-12-13T15:43:26Z
dc.date.available.fl_str_mv 2016-12-13T15:43:26Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DAMIÃO, Paciência de Almeida; et al. Human Papillomavirus types distribution among women with cervical preneoplastic, lesions and cancer in Luanda, Angola. Pan African Medical Journal, v. 24, n.268, 5p, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16523
dc.identifier.issn.pt_BR.fl_str_mv 1937-8688
dc.identifier.doi.none.fl_str_mv 10.11604/pamj.2016.24.268.9678
identifier_str_mv DAMIÃO, Paciência de Almeida; et al. Human Papillomavirus types distribution among women with cervical preneoplastic, lesions and cancer in Luanda, Angola. Pan African Medical Journal, v. 24, n.268, 5p, 2016.
1937-8688
10.11604/pamj.2016.24.268.9678
url https://www.arca.fiocruz.br/handle/icict/16523
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv AFNET
publisher.none.fl_str_mv AFNET
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/16523/2/michelle_silva_etal_IOC_2016.pdf
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