Human Papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil

Detalhes bibliográficos
Autor(a) principal: Santos, Silvia Helena Rabelo dos
Data de Publicação: 2003
Outros Autores: Zeferino, Luiz Carlos, Villa, Luisa Lina, Sobrinho, João Simão Pereira, Amaral, Rita Goreti, Magalhães, Albino Verçosa de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UnB
Texto Completo: http://repositorio.unb.br/handle/10482/2809
Resumo: This study estimated the prevalence and distribution of human papillomavirus (HPV) types among women with cervical intraepithelial neoplasia (CIN) grade III and invasive cervical cancer from Goiás (Brazil Central Region). Seventy-four cases were analyzed and consisted of 18 CIN III, 48 squamous cell carcinomas, 4 adenocarcinomas, 1 adenosquamous carcinoma and 3 undifferentiated carcinomas. HPV-DNA sequences were examined in formalinfixed and paraffin-embedded tissues using primers from L1 region GP5+/GP6+. Polymerase chain reaction products were typed with dot blot hybridization using probes for HPV 16, 18, 31, 33, 45, 54, 6/11, 42/43/44, 51/52, 56/ 58. The prevalence of HPV was estimated to be 76% (56/74). HPV 16 was the most frequently found type, followed by HPV 33, 18 and 31. The prevalence of untyped HPV was 6%; 79% percent of the squamous cell carcinoma cases and 61% percent of the CIN III were positive for HPV and the prevalence rate of HPV types was the same for the total number of cases. According to other studies, HPV type 16 is the most prevalent virus in all Brazilian regions, but there is variation regarding to other types. Type 18 is the second most prevalent HPV in North, Southeast and South Brazil regions and types 31 and 33 are the second most prevalent HPV in Northeast and Central Brazil, respectively.
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spelling Human Papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, BrazilPapilomavírus humanoCâncer cervicalThis study estimated the prevalence and distribution of human papillomavirus (HPV) types among women with cervical intraepithelial neoplasia (CIN) grade III and invasive cervical cancer from Goiás (Brazil Central Region). Seventy-four cases were analyzed and consisted of 18 CIN III, 48 squamous cell carcinomas, 4 adenocarcinomas, 1 adenosquamous carcinoma and 3 undifferentiated carcinomas. HPV-DNA sequences were examined in formalinfixed and paraffin-embedded tissues using primers from L1 region GP5+/GP6+. Polymerase chain reaction products were typed with dot blot hybridization using probes for HPV 16, 18, 31, 33, 45, 54, 6/11, 42/43/44, 51/52, 56/ 58. The prevalence of HPV was estimated to be 76% (56/74). HPV 16 was the most frequently found type, followed by HPV 33, 18 and 31. The prevalence of untyped HPV was 6%; 79% percent of the squamous cell carcinoma cases and 61% percent of the CIN III were positive for HPV and the prevalence rate of HPV types was the same for the total number of cases. According to other studies, HPV type 16 is the most prevalent virus in all Brazilian regions, but there is variation regarding to other types. Type 18 is the second most prevalent HPV in North, Southeast and South Brazil regions and types 31 and 33 are the second most prevalent HPV in Northeast and Central Brazil, respectively.Faculdade de Medicina (FMD)2009-12-21T19:10:56Z2009-12-21T19:10:56Z2003-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfRABELO-SANTOS, SH et al. Human papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v.98, n.2, p. 181-184, mar. 2003. doi: 10.1590/S0074-02762003000200003. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000200003&lng=en&nrm=iso>. Acesso em: 20 dez. 2009.http://repositorio.unb.br/handle/10482/2809Memórias do Instituto Oswaldo Cruz - Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons. Fonte: http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0074-02762003000200003&lng= pt&nrm=iso&tlng=en. Acesso em: 02 mar. 2014.info:eu-repo/semantics/openAccessSantos, Silvia Helena Rabelo dosZeferino, Luiz CarlosVilla, Luisa LinaSobrinho, João Simão PereiraAmaral, Rita GoretiMagalhães, Albino Verçosa deengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2023-08-25T03:06:38Zoai:repositorio.unb.br:10482/2809Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-08-25T03:06:38Repositório Institucional da UnB - Universidade de Brasília (UnB)false
dc.title.none.fl_str_mv Human Papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil
title Human Papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil
spellingShingle Human Papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil
Santos, Silvia Helena Rabelo dos
Papilomavírus humano
Câncer cervical
title_short Human Papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil
title_full Human Papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil
title_fullStr Human Papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil
title_full_unstemmed Human Papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil
title_sort Human Papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil
author Santos, Silvia Helena Rabelo dos
author_facet Santos, Silvia Helena Rabelo dos
Zeferino, Luiz Carlos
Villa, Luisa Lina
Sobrinho, João Simão Pereira
Amaral, Rita Goreti
Magalhães, Albino Verçosa de
author_role author
author2 Zeferino, Luiz Carlos
Villa, Luisa Lina
Sobrinho, João Simão Pereira
Amaral, Rita Goreti
Magalhães, Albino Verçosa de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, Silvia Helena Rabelo dos
Zeferino, Luiz Carlos
Villa, Luisa Lina
Sobrinho, João Simão Pereira
Amaral, Rita Goreti
Magalhães, Albino Verçosa de
dc.subject.por.fl_str_mv Papilomavírus humano
Câncer cervical
topic Papilomavírus humano
Câncer cervical
description This study estimated the prevalence and distribution of human papillomavirus (HPV) types among women with cervical intraepithelial neoplasia (CIN) grade III and invasive cervical cancer from Goiás (Brazil Central Region). Seventy-four cases were analyzed and consisted of 18 CIN III, 48 squamous cell carcinomas, 4 adenocarcinomas, 1 adenosquamous carcinoma and 3 undifferentiated carcinomas. HPV-DNA sequences were examined in formalinfixed and paraffin-embedded tissues using primers from L1 region GP5+/GP6+. Polymerase chain reaction products were typed with dot blot hybridization using probes for HPV 16, 18, 31, 33, 45, 54, 6/11, 42/43/44, 51/52, 56/ 58. The prevalence of HPV was estimated to be 76% (56/74). HPV 16 was the most frequently found type, followed by HPV 33, 18 and 31. The prevalence of untyped HPV was 6%; 79% percent of the squamous cell carcinoma cases and 61% percent of the CIN III were positive for HPV and the prevalence rate of HPV types was the same for the total number of cases. According to other studies, HPV type 16 is the most prevalent virus in all Brazilian regions, but there is variation regarding to other types. Type 18 is the second most prevalent HPV in North, Southeast and South Brazil regions and types 31 and 33 are the second most prevalent HPV in Northeast and Central Brazil, respectively.
publishDate 2003
dc.date.none.fl_str_mv 2003-03
2009-12-21T19:10:56Z
2009-12-21T19:10:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv RABELO-SANTOS, SH et al. Human papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v.98, n.2, p. 181-184, mar. 2003. doi: 10.1590/S0074-02762003000200003. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000200003&lng=en&nrm=iso>. Acesso em: 20 dez. 2009.
http://repositorio.unb.br/handle/10482/2809
identifier_str_mv RABELO-SANTOS, SH et al. Human papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v.98, n.2, p. 181-184, mar. 2003. doi: 10.1590/S0074-02762003000200003. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000200003&lng=en&nrm=iso>. Acesso em: 20 dez. 2009.
url http://repositorio.unb.br/handle/10482/2809
dc.language.iso.fl_str_mv eng
language eng
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UnB
instname:Universidade de Brasília (UnB)
instacron:UNB
instname_str Universidade de Brasília (UnB)
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institution UNB
reponame_str Repositório Institucional da UnB
collection Repositório Institucional da UnB
repository.name.fl_str_mv Repositório Institucional da UnB - Universidade de Brasília (UnB)
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