Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs
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Publication Date: | 2015 |
Other Authors: | , , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da FIOCRUZ (ARCA) |
Download full: | https://www.arca.fiocruz.br/handle/icict/13754 |
Summary: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, Brasil |
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Santos, Luciane AmorimGray, Rebecca RCunha, Joana Paixão MonteiroStrazza, EvandraKashima, Simone GSantos, Edson de SouzaAraújo, Thessika Hialla AlmeidaGonçalves, Marilda de SouzaSalemi, MarcoAlcantara, Luiz Carlos Júnior2016-04-13T19:15:48Z2016-04-13T19:15:48Z2015SANTOS, L. A. et al. Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs. AIDS Research Human Retroviruses, v. 31, n. 9, p. 913-920, 2015.0889-2229https://www.arca.fiocruz.br/handle/icict/13754engMary Ann LiebertHIVHIV-1TransmissãoAmamentaçãoFemininoCriançaShort communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, BrasilUniversity of Florida College of Medicine. Department of Pathology, Immunology, and Laboratory Medicine. Gainesville, FloridaFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilUniversidade de São Paulo. Hemocentro de Ribeirão Preto. São Paulo, SP, BrasilUniversidade de São Paulo. Hemocentro de Ribeirão Preto. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, BrasilUniversity of Florida College of Medicine. Department of Pathology, Immunology, and Laboratory Medicine. Gainesville, FloridaFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, BrasilCharacterizing the impact of HIV transmission routes on viral genetic diversity can improve the understanding of the mechanisms of virus evolution and adaptation. HIV vertical transmission can occur in utero, during delivery, or while breastfeeding. The present study investigated the phylodynamics of the HIV-1 env gene in mother-tochild transmission by analyzing one chronically infected pair from Brazil and three acutely infected pairs from Zambia, with three to five time points. Sequences from 25 clones from each sample were obtained and aligned using Clustal X. ML trees were constructed in PhyML using the best evolutionary model. Bayesian analyses testing the relaxed and strict molecular clock were performed using BEAST and a Bayesian Skyline Plot (BSP) was construed. The genetic variability of previously described epitopes was investigated and compared between each individual time point and between mother and child sequences. The relaxed molecular clock was the bestfitted model for all datasets. The tree topologies did not show differentiation in the evolutionary dynamics of the virus circulating in the mother from the viral population in the child. In the BSP, the effective population size was more constant in time in the chronically infected patients while in the acute patients it was possible to detect bottlenecks. The genetic variability within viral epitopes recognized by the human immune system was considerably higher among the chronically infected pair in comparison with acutely infected pairs. These results contribute to a better understanding of HIV-1 evolutionary dynamics in mother-to-child transmission.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13754/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSantos LA Short Communications Phylodynamics....pdfSantos LA Short Communications Phylodynamics....pdfapplication/pdf471633https://www.arca.fiocruz.br/bitstream/icict/13754/2/Santos%20LA%20Short%20Communications%20Phylodynamics....pdf44c725c25571d9a8241ad5e812f6978cMD52TEXTSantos LA Short Communications Phylodynamics....pdf.txtSantos LA Short Communications Phylodynamics....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs |
title |
Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs |
spellingShingle |
Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs Santos, Luciane Amorim HIV HIV-1 Transmissão Amamentação Feminino Criança |
title_short |
Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs |
title_full |
Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs |
title_fullStr |
Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs |
title_full_unstemmed |
Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs |
title_sort |
Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs |
author |
Santos, Luciane Amorim |
author_facet |
Santos, Luciane Amorim Gray, Rebecca R Cunha, Joana Paixão Monteiro Strazza, Evandra Kashima, Simone G Santos, Edson de Souza Araújo, Thessika Hialla Almeida Gonçalves, Marilda de Souza Salemi, Marco Alcantara, Luiz Carlos Júnior |
author_role |
author |
author2 |
Gray, Rebecca R Cunha, Joana Paixão Monteiro Strazza, Evandra Kashima, Simone G Santos, Edson de Souza Araújo, Thessika Hialla Almeida Gonçalves, Marilda de Souza Salemi, Marco Alcantara, Luiz Carlos Júnior |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Luciane Amorim Gray, Rebecca R Cunha, Joana Paixão Monteiro Strazza, Evandra Kashima, Simone G Santos, Edson de Souza Araújo, Thessika Hialla Almeida Gonçalves, Marilda de Souza Salemi, Marco Alcantara, Luiz Carlos Júnior |
dc.subject.other.pt_BR.fl_str_mv |
HIV HIV-1 Transmissão Amamentação Feminino Criança |
topic |
HIV HIV-1 Transmissão Amamentação Feminino Criança |
description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, Brasil |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2016-04-13T19:15:48Z |
dc.date.available.fl_str_mv |
2016-04-13T19:15:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTOS, L. A. et al. Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs. AIDS Research Human Retroviruses, v. 31, n. 9, p. 913-920, 2015. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/13754 |
dc.identifier.issn.none.fl_str_mv |
0889-2229 |
identifier_str_mv |
SANTOS, L. A. et al. Short communication: phylodynamics analysis of the human immunodeficiency virus type 1 envelope gene in mother and child pairs. AIDS Research Human Retroviruses, v. 31, n. 9, p. 913-920, 2015. 0889-2229 |
url |
https://www.arca.fiocruz.br/handle/icict/13754 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Mary Ann Liebert |
publisher.none.fl_str_mv |
Mary Ann Liebert |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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