Phylodynamics analysis of the Human Immunodeficiency Virus type 1 (HIV-1) envelope gene in mother and child pairs.

Detalhes bibliográficos
Autor(a) principal: Santos, Luciane Amorim
Data de Publicação: 2015
Outros Autores: Gray, Rebecca R, Cunha, Joana Paixão Monteiro, Strazza, Evandra, Kashima, Simone G, Souza, Edson de, Araújo, Thessika Hialla Almeida, Gonçalves, Marilda de Souza, Salemi, Marco, Alcantara, Luiz Carlos Júnior
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11375
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, Brasil
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spelling Santos, Luciane AmorimGray, Rebecca RCunha, Joana Paixão MonteiroStrazza, EvandraKashima, Simone GSouza, Edson deAraújo, Thessika Hialla AlmeidaGonçalves, Marilda de SouzaSalemi, MarcoAlcantara, Luiz Carlos Júnior2015-07-15T17:08:57Z2015-07-15T17:08:57Z2015SANTOS, L. A. et al. Phylodynamics analysis of the Human Immunodeficiency Virus type 1 (HIV-1) envelope gene in mother and child pairs. AIDS Research and Human Retroviruses, jun., 2015.0889-2229https://www.arca.fiocruz.br/handle/icict/1137510.1089/AID.2014.0352porMary Ann LiebertyPhylodynamics analysis of the Human Immunodeficiency Virus type 1 (HIV-1) envelope gene in mother and child pairs.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, BrasilUniversity of Florida College of Medicine. Department of Pathology, Immunology, and Laboratory Medicine. Gainesville, FL, USAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilUniversidade de São Paulo. Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, BrasilUniversidade de São Paulo. Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, BrasilUniversity of Florida College of Medicine. Department of Pathology, Immunology, and Laboratory Medicine. Gainesville, FL, USAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, BrasilCharacterizing the impact of HIV transmission routes on viral genetic diversity can improve the understanding of the mechanisms of virus evolution and adaptation. The HIV vertical transmission can occur in utero, during delivery or while breastfeeding. The present study investigated the phylodynamics of the HIV-1 env gene in mother-to-child transmission, by analyzing one chronically infected pair from Brazil and three acutely infected pairs from Zambia, with three to five time points. Sequences from 25 clones from each sample were obtained and aligned using Clustal X. ML trees were constructed in PhyML using the best evolutionary model. Bayesian analyses testing the relaxed and strict molecular clock were performed using BEAST and Bayesian Skyline Plot (BSP) was construed. The genetic variability of previously described epitopes were investigated and compared between each individual time points and between mother and child sequences. The relaxed molecular clock was the best-fitted model for all datasets. The tree topologies did not show differentiation in the evolutionary dynamics of the virus circulating in the mother from the child viral population. In the BSP, the effective population size was more constant along the time in the chronically infected patients while in the acute patients it was possible to detect bottlenecks. The genetic variability within viral epitopes recognized by the human immune system was considerably higher among the chronically infected pair in comparison with acutely infected pairs. These results contribute to the better understanding of the HIV-1 evolutionary dynamics in mother to child transmission.HIV-1Mother-to-childPhylodynamicsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11375/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALSantos LA Phylodinamics....pdfSantos LA Phylodinamics....pdfapplication/pdf792805https://www.arca.fiocruz.br/bitstream/icict/11375/2/Santos%20LA%20Phylodinamics....pdf8badb20fb8b2b1ad743cca4b1318a60bMD52TEXTSantos LA Phylodinamics....pdf.txtSantos LA Phylodinamics....pdf.txtExtracted texttext/plain41480https://www.arca.fiocruz.br/bitstream/icict/11375/3/Santos%20LA%20Phylodinamics....pdf.txtc808f4cd1e746eec6093931e6be2f07dMD53icict/113752023-03-15 14:33:07.424oai:www.arca.fiocruz.br:icict/11375Q0VTU8ODTyBOw4NPLUVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcyBhdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKQ0VERSBlIFRSQU5TRkVSRSwgdG90YWwgZSBncmF0dWl0YW1lbnRlLCDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVosIGVtIGNhcsOhdGVyIHBlcm1hbmVudGUsIGlycmV2b2fDoXZlbCBlIE7Dg08gRVhDTFVTSVZPLCAKdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08gQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcyAKZGUgdm96IGUgaW1hZ2VtIHZpbmN1bGFkb3Mgw6AgT0JSQSwgZHVyYW50ZSB0b2RvIG8gcHJhem8gZGUgZHVyYcOnw6NvIGRvcyBkaXJlaXRvcyBhdXRvcmFpcywgZW0gcXVhbHF1ZXIgaWRpb21hIGUgZW0gdG9kb3Mgb3MgcGHDrXNlczsKICAgICAgICAKQUNFSVRBIHF1ZSBhIGNlc3PDo28gdG90YWwgbsOjbyBleGNsdXNpdmEsIHBlcm1hbmVudGUgZSBpcnJldm9nw6F2ZWwgZG9zIGRpcmVpdG9zIGF1dG9yYWlzIHBhdHJpbW9uaWFpcyBuw6NvIGNvbWVyY2lhaXMgZGUgdXRpbGl6YcOnw6NvIApkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwgb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciAKbWVpbyBvdSB2ZcOtY3VsbywgaW5jbHVzaXZlIGVtIFJlcG9zaXTDs3Jpb3MgRGlnaXRhaXMsIGJlbSBjb21vIG9zIGRpcmVpdG9zIGRlIHJlcHJvZHXDp8OjbywgZXhpYmnDp8OjbywgZXhlY3XDp8OjbywgZGVjbGFtYcOnw6NvLCBleHBvc2nDp8OjbywgCmFycXVpdmFtZW50bywgaW5jbHVzw6NvIGVtIGJhbmNvIGRlIGRhZG9zLCBwcmVzZXJ2YcOnw6NvLCBkaWZ1c8OjbywgZGlzdHJpYnVpw6fDo28sIGRpdnVsZ2HDp8OjbywgZW1wcsOpc3RpbW8sIHRyYWR1w6fDo28sIGluY2x1c8OjbyBlbSBub3ZhcyAKb2JyYXMgb3UgY29sZXTDom5lYXMsIHJldXRpbGl6YcOnw6NvLCBlZGnDp8OjbywgcHJvZHXDp8OjbyBkZSBtYXRlcmlhbCBkaWTDoXRpY28gZSBjdXJzb3Mgb3UgcXVhbHF1ZXIgZm9ybWEgZGUgdXRpbGl6YcOnw6NvIG7Do28gY29tZXJjaWFsOwogICAgICAgIApSRUNPTkhFQ0UgcXVlIGEgY2Vzc8OjbyBhcXVpIGVzcGVjaWZpY2FkYSBjb25jZWRlIMOgIEZJT0NSVVogLSBGVU5EQcOHw4NPIE9TV0FMRE8gQ1JVWiBvIGRpcmVpdG8gZGUgYXV0b3JpemFyIHF1YWxxdWVyIHBlc3NvYSDigJMgZsOtc2ljYSAKb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdSBlc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlciAKZmluYWxpZGFkZXMgbsOjbyBjb21lcmNpYWlzOwogICAgICAgIApERUNMQVJBIHF1ZSBhIG9icmEgw6kgY3JpYcOnw6NvIG9yaWdpbmFsIGUgcXVlIMOpIG8gdGl0dWxhciBkb3MgZGlyZWl0b3MgYXF1aSBjZWRpZG9zIGUgYXV0b3JpemFkb3MsIHJlc3BvbnNhYmlsaXphbmRvLXNlIGludGVncmFsbWVudGUgCnBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwgaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIAppbmRlbml6YXIgdGVyY2Vpcm9zIHBvciBkYW5vcywgYmVtIGNvbW8gaW5kZW5pemFyIGUgcmVzc2FyY2lyIMOgIEZJT0NSVVogLSBGVU5EQcOHw4NPIE9TV0FMRE8gQ1JVWiBkZSBldmVudHVhaXMgZGVzcGVzYXMgcXVlIHZpZXJlbSBhIApzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91IGRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIAplIHZpb2xhw6fDtWVzIGRlIGRpcmVpdG9zOwogICAgICAgIApBRklSTUEgcXVlIGNvbmhlY2UgYSBQb2zDrXRpY2EgSW5zdGl0dWNpb25hbCBkZSBBY2Vzc28gQWJlcnRvIGRhIEluc3RpdHVpw6fDo28gZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyAKaW5zdGl0dWNpb25hbCBBUkNBLgo=Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:07Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Phylodynamics analysis of the Human Immunodeficiency Virus type 1 (HIV-1) envelope gene in mother and child pairs.
title Phylodynamics analysis of the Human Immunodeficiency Virus type 1 (HIV-1) envelope gene in mother and child pairs.
spellingShingle Phylodynamics analysis of the Human Immunodeficiency Virus type 1 (HIV-1) envelope gene in mother and child pairs.
Santos, Luciane Amorim
HIV-1
Mother-to-child
Phylodynamics
title_short Phylodynamics analysis of the Human Immunodeficiency Virus type 1 (HIV-1) envelope gene in mother and child pairs.
title_full Phylodynamics analysis of the Human Immunodeficiency Virus type 1 (HIV-1) envelope gene in mother and child pairs.
title_fullStr Phylodynamics analysis of the Human Immunodeficiency Virus type 1 (HIV-1) envelope gene in mother and child pairs.
title_full_unstemmed Phylodynamics analysis of the Human Immunodeficiency Virus type 1 (HIV-1) envelope gene in mother and child pairs.
title_sort Phylodynamics analysis of the Human Immunodeficiency Virus type 1 (HIV-1) envelope gene in mother and child pairs.
author Santos, Luciane Amorim
author_facet Santos, Luciane Amorim
Gray, Rebecca R
Cunha, Joana Paixão Monteiro
Strazza, Evandra
Kashima, Simone G
Souza, Edson de
Araújo, Thessika Hialla Almeida
Gonçalves, Marilda de Souza
Salemi, Marco
Alcantara, Luiz Carlos Júnior
author_role author
author2 Gray, Rebecca R
Cunha, Joana Paixão Monteiro
Strazza, Evandra
Kashima, Simone G
Souza, Edson de
Araújo, Thessika Hialla Almeida
Gonçalves, Marilda de Souza
Salemi, Marco
Alcantara, Luiz Carlos Júnior
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, Luciane Amorim
Gray, Rebecca R
Cunha, Joana Paixão Monteiro
Strazza, Evandra
Kashima, Simone G
Souza, Edson de
Araújo, Thessika Hialla Almeida
Gonçalves, Marilda de Souza
Salemi, Marco
Alcantara, Luiz Carlos Júnior
dc.subject.en.pt_BR.fl_str_mv HIV-1
Mother-to-child
Phylodynamics
topic HIV-1
Mother-to-child
Phylodynamics
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratorio de Hematologia Genética e Biologia Computacional. Salvador, BA, Brasil
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-07-15T17:08:57Z
dc.date.available.fl_str_mv 2015-07-15T17:08:57Z
dc.date.issued.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, L. A. et al. Phylodynamics analysis of the Human Immunodeficiency Virus type 1 (HIV-1) envelope gene in mother and child pairs. AIDS Research and Human Retroviruses, jun., 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11375
dc.identifier.issn.none.fl_str_mv 0889-2229
dc.identifier.doi.none.fl_str_mv 10.1089/AID.2014.0352
identifier_str_mv SANTOS, L. A. et al. Phylodynamics analysis of the Human Immunodeficiency Virus type 1 (HIV-1) envelope gene in mother and child pairs. AIDS Research and Human Retroviruses, jun., 2015.
0889-2229
10.1089/AID.2014.0352
url https://www.arca.fiocruz.br/handle/icict/11375
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Mary Ann Lieberty
publisher.none.fl_str_mv Mary Ann Lieberty
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/11375/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/11375/2/Santos%20LA%20Phylodinamics....pdf
https://www.arca.fiocruz.br/bitstream/icict/11375/3/Santos%20LA%20Phylodinamics....pdf.txt
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