Vertical Human Immunodeficiency Virus Type 1 - HIV-1 -Transmission - A Review

Detalhes bibliográficos
Autor(a) principal: Bongertz, Vera
Data de Publicação: 2001
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1590/S0074-02762001000100001
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44106
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Aids e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
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spelling Bongertz, Vera2020-10-21T19:38:03Z2020-10-21T19:38:03Z2001BONGERTZ, Vera. Vertical Human Immunodeficiency Virus Type 1 - HIV-1 -Transmission - A Review. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 96, n. 1, p. 1-14, Jan. 2001.0074-0276https://www.arca.fiocruz.br/handle/icict/4410610.1590/S0074-027620010001000011678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.HIV-1Transmissão vertical do virus HV-1HIV-1Vertical HIV-1 transmissionVertical Human Immunodeficiency Virus Type 1 - HIV-1 -Transmission - A Reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Aids e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Several factors appear to affect vertical HIV-1 transmission, dependent mainly on characteristics of the mother (extent of immunodeficiency, co-infections, risk behaviour, nutritional status, immune response, genetical make-up), but also of the virus (phenotype, tropism) and, possibly, of the child (genetical make-up). This complex situation is compounded by the fact that the virus may have the whole gestation period, apart from variable periods between membrane rupture and birth and the breast-feeding period, to pass from the mother to the infant. It seems probable that an extensive interplay of all factors occurs, and that some factors may be more important during specific periods and other factors in other periods. Factors predominant in protection against in utero transmission may be less important for peri-natal transmission, and probably quite different from those that predominantly affect transmission by mothers milk. For instance, cytotoxic T lymphocytes will probably be unable to exert any effect during breast-feeding, while neutralizing antibodies will be unable to protect transmission by HIV transmitted through infected cells. Furthermore, some responses may be capable of controlling transmission of determined virus types, while being inadequate for controlling others. As occurence of mixed infections and recombination of HIV-1 types is a known fact, it does not appear possible to prevent vertical HIV-1 transmission by reinforcing just one of the factors, and probably a general strategy including all known factors must be used. 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dc.title.pt_BR.fl_str_mv Vertical Human Immunodeficiency Virus Type 1 - HIV-1 -Transmission - A Review
title Vertical Human Immunodeficiency Virus Type 1 - HIV-1 -Transmission - A Review
spellingShingle Vertical Human Immunodeficiency Virus Type 1 - HIV-1 -Transmission - A Review
Bongertz, Vera
HIV-1
Transmissão vertical do virus HV-1
HIV-1
Vertical HIV-1 transmission
title_short Vertical Human Immunodeficiency Virus Type 1 - HIV-1 -Transmission - A Review
title_full Vertical Human Immunodeficiency Virus Type 1 - HIV-1 -Transmission - A Review
title_fullStr Vertical Human Immunodeficiency Virus Type 1 - HIV-1 -Transmission - A Review
title_full_unstemmed Vertical Human Immunodeficiency Virus Type 1 - HIV-1 -Transmission - A Review
title_sort Vertical Human Immunodeficiency Virus Type 1 - HIV-1 -Transmission - A Review
author Bongertz, Vera
author_facet Bongertz, Vera
author_role author
dc.contributor.author.fl_str_mv Bongertz, Vera
dc.subject.other.pt_BR.fl_str_mv HIV-1
Transmissão vertical do virus HV-1
topic HIV-1
Transmissão vertical do virus HV-1
HIV-1
Vertical HIV-1 transmission
dc.subject.en.pt_BR.fl_str_mv HIV-1
Vertical HIV-1 transmission
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Aids e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2020-10-21T19:38:03Z
dc.date.available.fl_str_mv 2020-10-21T19:38:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv BONGERTZ, Vera. Vertical Human Immunodeficiency Virus Type 1 - HIV-1 -Transmission - A Review. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 96, n. 1, p. 1-14, Jan. 2001.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44106
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762001000100001
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv BONGERTZ, Vera. Vertical Human Immunodeficiency Virus Type 1 - HIV-1 -Transmission - A Review. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 96, n. 1, p. 1-14, Jan. 2001.
0074-0276
10.1590/S0074-02762001000100001
1678-8060
url https://www.arca.fiocruz.br/handle/icict/44106
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
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