Untargeted metabolomics insights into newborns with congenital Zika infection

Detalhes bibliográficos
Autor(a) principal: Nunes, Estéfane da C.
Data de Publicação: 2021
Outros Autores: Filippis, Ana M. B. de, Pereira, Taiane do E. S., Faria, Nieli R. da C., Salgado, Álvaro, Santos, Cleiton S., Carvalho, Teresa C. P. X., Calcagno, Juan I., Chalhoub, Flávia L. L., Brown, David, Giovanetti, Marta, Alcantara, Luiz Carlos Junior, Barreto, Fernanda K., Siqueira, Isadora C. de, Canuto, Gisele A. B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/47919
Resumo: Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) under the grant number E-26/2002.930/2016
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spelling Nunes, Estéfane da C.Filippis, Ana M. B. dePereira, Taiane do E. S.Faria, Nieli R. da C.Salgado, ÁlvaroSantos, Cleiton S.Carvalho, Teresa C. P. X.Calcagno, Juan I.Chalhoub, Flávia L. L.Brown, DavidGiovanetti, MartaAlcantara, Luiz Carlos JuniorBarreto, Fernanda K.Siqueira, Isadora C. deCanuto, Gisele A. B.2021-06-29T17:25:39Z2021-06-29T17:25:39Z2021NUNES, Estéfane da C. et al. Untargeted metabolomics insights into newborns with congenital Zika infection. Pathogens, v. 10, n. 4, p. 1-13, 13 Apr. 2021.2076-0817https://www.arca.fiocruz.br/handle/icict/4791910.3390/pathogens10040468Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) under the grant number E-26/2002.930/2016Canadian International Development Research Centre (IDRC), grant number 108411-001Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) grant number 443875/2018-9Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) grant number 5125/2017)Universidade Federal da Bahia. Instituto de Química. Departamento de Química Analítica. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Universidade Federal da Bahia. Instituto de Química. Departamento de Química Analítica. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Secretaria de Saúde do Estado da Bahia. Maternidade de Referência Prof. José Maria de Magalhães Netto. Salvador, BA, Brasil.Secretaria de Saúde do Estado da Bahia. Maternidade de Referência Prof. José Maria de Magalhães Netto. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil.Universidade Federal da Bahia. Instituto Multidisciplinar em Saúde. Vitória da Conquista, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Química. Departamento de Química Analítica. Salvador, BA, Brasil.Zika virus (ZIKV), an emerging virus belonging to the Flaviviridae family, causes severe neurological clinical complications and has been associated with Guillain-Barré syndrome, fetal abnormalities known collectively as congenital Zika syndrome, and microcephaly. Studies have shown that ZIKV infection can alter cellular metabolism, directly affecting neural development. Brain growth requires controlled cellular metabolism, which is essential for cell proliferation and maturation. However, little is known regarding the metabolic profile of ZIKV-infected newborns and possible associations related to microcephaly. Furthering the understanding surrounding underlying mechanisms is essential to developing personalized treatments for affected individuals. Thus, metabolomics, the study of the metabolites produced by or modified in an organism, constitutes a valuable approach in the study of complex diseases. Here, 26 serum samples from ZIKV-positive newborns with or without microcephaly, as well as controls, were analyzed using an untargeted metabolomics approach involving gas chromatography–mass spectrometry (GC-MS). Significant alterations in essential and non-essential amino acids, as well as carbohydrates (including aldohexoses, such as glucose or mannose) and their derivatives (urea and pyruvic acid), were observed in the metabolic profiles analyzed. Our results provide insight into relevant metabolic processes in patients with ZIKV and microcephalyengMDPIVírus ZikaMicrocefaliaMetabolômicaSíndrome de Guillain-BarréAprendizado de máquinaFlaviviridaeZika VirusMicrocephalyMetabolomicsGC-MSMachine learningUntargeted metabolomics insights into newborns with congenital Zika infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/47919/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALNunes, Estefane C Untergeted....pdfNunes, Estefane C Untergeted....pdfapplication/pdf1002819https://www.arca.fiocruz.br/bitstream/icict/47919/2/Nunes%2c%20Estefane%20C%20Untergeted....pdfef046eb8c6fdaadec24f3687c421dc34MD52TEXTNunes, Estefane C Untergeted....pdf.txtNunes, Estefane C 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dc.title.en.fl_str_mv Untargeted metabolomics insights into newborns with congenital Zika infection
title Untargeted metabolomics insights into newborns with congenital Zika infection
spellingShingle Untargeted metabolomics insights into newborns with congenital Zika infection
Nunes, Estéfane da C.
Vírus Zika
Microcefalia
Metabolômica
Síndrome de Guillain-Barré
Aprendizado de máquina
Flaviviridae
Zika Virus
Microcephaly
Metabolomics
GC-MS
Machine learning
title_short Untargeted metabolomics insights into newborns with congenital Zika infection
title_full Untargeted metabolomics insights into newborns with congenital Zika infection
title_fullStr Untargeted metabolomics insights into newborns with congenital Zika infection
title_full_unstemmed Untargeted metabolomics insights into newborns with congenital Zika infection
title_sort Untargeted metabolomics insights into newborns with congenital Zika infection
author Nunes, Estéfane da C.
author_facet Nunes, Estéfane da C.
Filippis, Ana M. B. de
Pereira, Taiane do E. S.
Faria, Nieli R. da C.
Salgado, Álvaro
Santos, Cleiton S.
Carvalho, Teresa C. P. X.
Calcagno, Juan I.
Chalhoub, Flávia L. L.
Brown, David
Giovanetti, Marta
Alcantara, Luiz Carlos Junior
Barreto, Fernanda K.
Siqueira, Isadora C. de
Canuto, Gisele A. B.
author_role author
author2 Filippis, Ana M. B. de
Pereira, Taiane do E. S.
Faria, Nieli R. da C.
Salgado, Álvaro
Santos, Cleiton S.
Carvalho, Teresa C. P. X.
Calcagno, Juan I.
Chalhoub, Flávia L. L.
Brown, David
Giovanetti, Marta
Alcantara, Luiz Carlos Junior
Barreto, Fernanda K.
Siqueira, Isadora C. de
Canuto, Gisele A. B.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nunes, Estéfane da C.
Filippis, Ana M. B. de
Pereira, Taiane do E. S.
Faria, Nieli R. da C.
Salgado, Álvaro
Santos, Cleiton S.
Carvalho, Teresa C. P. X.
Calcagno, Juan I.
Chalhoub, Flávia L. L.
Brown, David
Giovanetti, Marta
Alcantara, Luiz Carlos Junior
Barreto, Fernanda K.
Siqueira, Isadora C. de
Canuto, Gisele A. B.
dc.subject.other.pt_BR.fl_str_mv Vírus Zika
Microcefalia
Metabolômica
Síndrome de Guillain-Barré
Aprendizado de máquina
Flaviviridae
topic Vírus Zika
Microcefalia
Metabolômica
Síndrome de Guillain-Barré
Aprendizado de máquina
Flaviviridae
Zika Virus
Microcephaly
Metabolomics
GC-MS
Machine learning
dc.subject.en.en.fl_str_mv Zika Virus
Microcephaly
Metabolomics
GC-MS
Machine learning
description Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) under the grant number E-26/2002.930/2016
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-06-29T17:25:39Z
dc.date.available.fl_str_mv 2021-06-29T17:25:39Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NUNES, Estéfane da C. et al. Untargeted metabolomics insights into newborns with congenital Zika infection. Pathogens, v. 10, n. 4, p. 1-13, 13 Apr. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/47919
dc.identifier.issn.pt_BR.fl_str_mv 2076-0817
dc.identifier.doi.pt_BR.fl_str_mv 10.3390/pathogens10040468
identifier_str_mv NUNES, Estéfane da C. et al. Untargeted metabolomics insights into newborns with congenital Zika infection. Pathogens, v. 10, n. 4, p. 1-13, 13 Apr. 2021.
2076-0817
10.3390/pathogens10040468
url https://www.arca.fiocruz.br/handle/icict/47919
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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