Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/17707 |
Resumo: | Intramural Program at the National Cancer Institute, National Institutes of Health, Bethesda, MD. |
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Barreto, Fernanda KhouriCunha, Antonio Ricardo KhouriRego, Filipe Ferreira de AlmeidaSantos, Luciane AmorimAmarante, Maria Fernanda de CastroBialuk, IzabelaMasison, Cynthia A PiseCastro Filho, Bernardo GalvãoGessain, AntoineJacobson, StevenFranchini, GenoveffaAlcantara, Luiz Carlos Júnior2017-02-07T17:27:13Z2017-02-07T17:27:13Z2016BARRETO, F. K. et al. Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome. Infection, Genetics and Evolution, v. 45, p. 420–425, 2016.1567-1348https://www.arca.fiocruz.br/handle/icict/1770710.1016/j.meegid.2016.08.020Intramural Program at the National Cancer Institute, National Institutes of Health, Bethesda, MD.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia Genética e Biologia Computacional. Salvador, Bahia, Brazil. Salvador, BA, BrasilRega Institute for Medical Research. Laboratory of Clinical and Epidemiological Virology. KU Leuven. Department of Microbiology and Immunology. Leuven, BelgiumFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia Genética e Biologia Computacional. Salvador, Bahia, Brazil. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia Genética e Biologia Computacional. Salvador, Bahia, Brazil. Salvador, BA, BrasilNational Cancer Institute. Animal Models and Retroviral Vaccines Section. Bethesda, USAMedical University in Białystok. Department of General and Experimental Pathology. PolandNational Cancer Institute. Animal Models and Retroviral Vaccines Section. Bethesda, USAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia Genética e Biologia Computacional. Salvador, Bahia, Brazil. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Publica, Salvador, Bahia, BrazilInstitut Pasteur. Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes. Département de Virologie. Batiment Lwoff. Paris, FranceNational Institute of Neurological Disorders and Stroke. Viral Immunology Section. Neuroimmunology Branch. Bethesda, USANational Cancer Institute. Animal Models and Retroviral Vaccines Section. Bethesda, USAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia Genética e Biologia Computacional. Salvador, Bahia, Brazil. Salvador, BA, BrasilThe region known as pX in the 3' end of the human T-cell lymphotropic virus type 1 (HTLV-1) genome contains four overlapping open reading frames (ORF) that encode regulatory proteins. HTLV-1 ORF-I produces the protein p12 and its cleavage product p8. The functions of these proteins have been linked to immune evasion and viral infectivity and persistence. It is known that the HTLV-1 infection does not necessarily imply the development of pathological processes and here we evaluated whether natural mutations in HTLV-1 ORF-I can influence the proviral load and clinical manifestation of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). For that, we performed molecular characterization, datamining and phylogenetic analysis with HTLV-1 ORF-I sequences from 156 patients with negative or positive diagnosis for HAM/TSP. Our analyses demonstrated that some mutations may be associated with the outcome of HAM/TSP (C39R, L40F, P45L, S69G and R88K) or with proviral load (P34L and F61L). We further examined the presence of mutations in motifs of HBZ and observed that P45L mutation is located within the HBZ nuclear localization signal and was found more frequently between patients with HAM/TSP and high proviral load. These results indicate that some natural mutations are located in functional domains of ORF-I and suggests a potential association between these mutations and the proviral loads and development of HAM/TSP. Therefore it is necessary to conduct functional studies aimed at evaluating the impact of these mutations on the virus persistence and immune evasion.engElsevierHTLV-1ORF-1MutaçõesInfecçãoMielopatiaHTLV-1ORF-1HAM/TSPMutationMyelopathyInfectionAnalyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcomeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17707/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBarreto FK Analyses of HTLV-1....pdfBarreto FK Analyses of HTLV-1....pdfapplication/pdf774321https://www.arca.fiocruz.br/bitstream/icict/17707/2/Barreto%20FK%20Analyses%20of%20HTLV-1....pdf846ba39f31670694c5636f1a27c389d0MD52TEXTBarreto FK Analyses of HTLV-1....pdf.txtBarreto FK Analyses 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| dc.title.pt_BR.fl_str_mv |
Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome |
| title |
Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome |
| spellingShingle |
Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome Barreto, Fernanda Khouri HTLV-1 ORF-1 Mutações Infecção Mielopatia HTLV-1 ORF-1 HAM/TSP Mutation Myelopathy Infection |
| title_short |
Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome |
| title_full |
Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome |
| title_fullStr |
Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome |
| title_full_unstemmed |
Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome |
| title_sort |
Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome |
| author |
Barreto, Fernanda Khouri |
| author_facet |
Barreto, Fernanda Khouri Cunha, Antonio Ricardo Khouri Rego, Filipe Ferreira de Almeida Santos, Luciane Amorim Amarante, Maria Fernanda de Castro Bialuk, Izabela Masison, Cynthia A Pise Castro Filho, Bernardo Galvão Gessain, Antoine Jacobson, Steven Franchini, Genoveffa Alcantara, Luiz Carlos Júnior |
| author_role |
author |
| author2 |
Cunha, Antonio Ricardo Khouri Rego, Filipe Ferreira de Almeida Santos, Luciane Amorim Amarante, Maria Fernanda de Castro Bialuk, Izabela Masison, Cynthia A Pise Castro Filho, Bernardo Galvão Gessain, Antoine Jacobson, Steven Franchini, Genoveffa Alcantara, Luiz Carlos Júnior |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Barreto, Fernanda Khouri Cunha, Antonio Ricardo Khouri Rego, Filipe Ferreira de Almeida Santos, Luciane Amorim Amarante, Maria Fernanda de Castro Bialuk, Izabela Masison, Cynthia A Pise Castro Filho, Bernardo Galvão Gessain, Antoine Jacobson, Steven Franchini, Genoveffa Alcantara, Luiz Carlos Júnior |
| dc.subject.other.pt_BR.fl_str_mv |
HTLV-1 ORF-1 Mutações Infecção Mielopatia |
| topic |
HTLV-1 ORF-1 Mutações Infecção Mielopatia HTLV-1 ORF-1 HAM/TSP Mutation Myelopathy Infection |
| dc.subject.en.pt_BR.fl_str_mv |
HTLV-1 ORF-1 HAM/TSP Mutation Myelopathy Infection |
| description |
Intramural Program at the National Cancer Institute, National Institutes of Health, Bethesda, MD. |
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2016 |
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2016 |
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2017-02-07T17:27:13Z |
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2017-02-07T17:27:13Z |
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BARRETO, F. K. et al. Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome. Infection, Genetics and Evolution, v. 45, p. 420–425, 2016. |
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https://www.arca.fiocruz.br/handle/icict/17707 |
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1567-1348 |
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10.1016/j.meegid.2016.08.020 |
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BARRETO, F. K. et al. Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome. Infection, Genetics and Evolution, v. 45, p. 420–425, 2016. 1567-1348 10.1016/j.meegid.2016.08.020 |
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