Putative role of HLA polymorphism among a Brazilian HTLV‑1‑associated myelopathy/ tropical spastic paraparesis (HAM/ TSP) population

Detalhes bibliográficos
Autor(a) principal: Schor, Doris
Data de Publicação: 2023
Outros Autores: Porto, Luís Cristóvão, Roma, Eric Henrique, Castro‑Alves, Julio, Villela, Anna Paula, Araújo, Abelardo Q. C., Bonecini‑Almeida, Maria Glória
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/59835
Resumo: This work was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico [Grant No. 477734/07-3] and INI/Fiocruz. The funding agency had no role in the study and collection, analysis, and interpretation of data and in writing the manuscript.
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spelling Schor, DorisPorto, Luís CristóvãoRoma, Eric HenriqueCastro‑Alves, JulioVillela, Anna PaulaAraújo, Abelardo Q. C.Bonecini‑Almeida, Maria Glória2023-07-28T18:44:05Z2023-07-28T18:44:05Z2023SCHOR, Doris et al. Putative role of HLA polymorphism among a Brazilian HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) population. Scientific Reports, v. 13, n. 1, p. 1-11, May 2023.2045-2322https://www.arca.fiocruz.br/handle/icict/5983510.1038/s41598-023-34757-w2045-2322This work was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico [Grant No. 477734/07-3] and INI/Fiocruz. The funding agency had no role in the study and collection, analysis, and interpretation of data and in writing the manuscript.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Imunologia e Imunogenética em Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Laboratório de Histocompatibilidade e Criopreservação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Imunologia e Imunogenética em Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Plataforma de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Laboratório de Histocompatibilidade e Criopreservação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil.Around ten million people are infected with HTLV-1 worldwide, and 1-4% develop HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), characterized by an important degeneration of the spinal cord, which can lead to death. Distinct HLA alleles have been associated with either HAM/TSP susceptibility or protection. However, these HLA alleles set may change according to the population studied. Brazil is the second country in the number of HTLV-1-infected people and there are few reports addressing the HLA influence on HTLV-1 infection as well as on disease outcome. The objective of this study was to evaluate the influence of HLA alleles as a risk factor for HAM/TSP and the proviral load (PVL) levels, clinical progression, and death outcomes in an admixed Brazilian population. The HLA-A, -B, -C, and -DRB1 were genotyped in 375 unrelated HTLV-1-infected individuals divided into asymptomatic carriers (AC) (n = 165) and HAM/TSP (n = 210) in a longitudinal cohort from 8 to 22 years of follow-up. Because locus B deviated from Hardy-Weinberg Equilibrium for the study groups, the results represented for HLA-B alleles were inconclusive. The alleles HLA-A*68 and -C*07 were related to HAM/TSP risk in multivariate analysis. The alleles HLA-A*33, and -A*36 were associated with protection against disease progression in HAM/TSP patients, while -C*12, -C*14, and -DRB1*08 were associated with increased risk of death. In the AC group, the presence of, -C*06 and -DRB1*15 alleles influenced an increased PVL, in an adjusted linear regression model, while -A*30, -A*34, -C*06, -C*17 and -DRB1*09 alleles were associated with increased PVL in HAM/TSP group compared to HAM/TSP individuals not carrying these alleles. All these alleles were also related to increased PVL associated with clinical progression outcome. Increased PVL associated with the death outcome was linked to the presence of HLA-A*30. PVL has been associated with HLA, and several alleles were related in AC and HAM/TSP patients with or without interacting with clinical progression outcomes. Understanding the prognostic value of HLA in HAM/TSP pathogenesis can provide important biomarkers tools to improve clinical management and contribute to the discovery of new therapeutic interventions.engNature Publishing GroupPutative role of HLA polymorphism among a Brazilian HTLV‑1‑associated myelopathy/ tropical spastic paraparesis (HAM/ TSP) populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHTLV‑1Myelopathy tropical spastic paraparesis (HAM/ TSP)HTLV‑1‑infected peopleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv Putative role of HLA polymorphism among a Brazilian HTLV‑1‑associated myelopathy/ tropical spastic paraparesis (HAM/ TSP) population
title Putative role of HLA polymorphism among a Brazilian HTLV‑1‑associated myelopathy/ tropical spastic paraparesis (HAM/ TSP) population
spellingShingle Putative role of HLA polymorphism among a Brazilian HTLV‑1‑associated myelopathy/ tropical spastic paraparesis (HAM/ TSP) population
Schor, Doris
HTLV‑1
Myelopathy tropical spastic paraparesis (HAM/ TSP)
HTLV‑1‑infected people
title_short Putative role of HLA polymorphism among a Brazilian HTLV‑1‑associated myelopathy/ tropical spastic paraparesis (HAM/ TSP) population
title_full Putative role of HLA polymorphism among a Brazilian HTLV‑1‑associated myelopathy/ tropical spastic paraparesis (HAM/ TSP) population
title_fullStr Putative role of HLA polymorphism among a Brazilian HTLV‑1‑associated myelopathy/ tropical spastic paraparesis (HAM/ TSP) population
title_full_unstemmed Putative role of HLA polymorphism among a Brazilian HTLV‑1‑associated myelopathy/ tropical spastic paraparesis (HAM/ TSP) population
title_sort Putative role of HLA polymorphism among a Brazilian HTLV‑1‑associated myelopathy/ tropical spastic paraparesis (HAM/ TSP) population
author Schor, Doris
author_facet Schor, Doris
Porto, Luís Cristóvão
Roma, Eric Henrique
Castro‑Alves, Julio
Villela, Anna Paula
Araújo, Abelardo Q. C.
Bonecini‑Almeida, Maria Glória
author_role author
author2 Porto, Luís Cristóvão
Roma, Eric Henrique
Castro‑Alves, Julio
Villela, Anna Paula
Araújo, Abelardo Q. C.
Bonecini‑Almeida, Maria Glória
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Schor, Doris
Porto, Luís Cristóvão
Roma, Eric Henrique
Castro‑Alves, Julio
Villela, Anna Paula
Araújo, Abelardo Q. C.
Bonecini‑Almeida, Maria Glória
dc.subject.en.en_US.fl_str_mv HTLV‑1
Myelopathy tropical spastic paraparesis (HAM/ TSP)
HTLV‑1‑infected people
topic HTLV‑1
Myelopathy tropical spastic paraparesis (HAM/ TSP)
HTLV‑1‑infected people
description This work was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico [Grant No. 477734/07-3] and INI/Fiocruz. The funding agency had no role in the study and collection, analysis, and interpretation of data and in writing the manuscript.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-07-28T18:44:05Z
dc.date.available.fl_str_mv 2023-07-28T18:44:05Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SCHOR, Doris et al. Putative role of HLA polymorphism among a Brazilian HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) population. Scientific Reports, v. 13, n. 1, p. 1-11, May 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/59835
dc.identifier.issn.en_US.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-023-34757-w
dc.identifier.eissn.none.fl_str_mv 2045-2322
identifier_str_mv SCHOR, Doris et al. Putative role of HLA polymorphism among a Brazilian HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) population. Scientific Reports, v. 13, n. 1, p. 1-11, May 2023.
2045-2322
10.1038/s41598-023-34757-w
url https://www.arca.fiocruz.br/handle/icict/59835
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/59835/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/59835/2/ve_Schor_Doris_INI_2023.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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