The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease
Autor(a) principal: | |
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Data de Publicação: | 2017 |
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Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25414 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Faculty of Medicine of Petrópolis. Petrópolis, RJ, Brazil |
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Mengel, JoseCardillo, Fabíola2018-03-20T13:11:33Z2018-03-20T13:11:33Z2017MENGEL, J.; CARDILLO, F. The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease. Cellular Immunology and Serum Biology, v. 3, n. 2, p. 120-121, 2017.2471-5891https://www.arca.fiocruz.br/handle/icict/25414engOmmega PublishersDoença de ChagasTrypanosoma cruziInsuficiência cardíacaHumanosInfecçãoChagas diseaseTrypanosoma cruziCardiac insufficiencyHumansInfectionThe Interleukin-17 (IL-17) Puzzle in Chagas’ Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Faculty of Medicine of Petrópolis. Petrópolis, RJ, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilIn this article, we discuss an alternative explanation for the fact that the production and plasma levels of IL-17 are diminished in patients chronically infected with Trypanosoma cruzi, suffering from congestive heart failure. This alternate hypothesis considers the inhibitory pharmacological action of digoxin, a drug commonly used to treat heart failure. We believe this is a significant point to be further studied as IL-17 was initially considered to be heart-protective. Therefore, our argument has profound therapeutic implicationsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25414/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMengel J The Interleukin-17 (IL-17) puzzle ....pdfMengel J The Interleukin-17 (IL-17) puzzle ....pdfapplication/pdf416819https://www.arca.fiocruz.br/bitstream/icict/25414/2/Mengel%20J%20The%20Interleukin-17%20%28IL-17%29%20puzzle%20....pdf341236ff108c0829c4429bb88a1cddcfMD52TEXTMengel J The Interleukin-17 (IL-17) puzzle ....pdf.txtMengel J The Interleukin-17 (IL-17) puzzle ....pdf.txtExtracted texttext/plain11318https://www.arca.fiocruz.br/bitstream/icict/25414/3/Mengel%20J%20The%20Interleukin-17%20%28IL-17%29%20puzzle%20....pdf.txt807436e6ed7a12eff2ea3d5bd2fe72daMD53icict/254142023-03-15 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dc.title.pt_BR.fl_str_mv |
The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease |
title |
The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease |
spellingShingle |
The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease Mengel, Jose Doença de Chagas Trypanosoma cruzi Insuficiência cardíaca Humanos Infecção Chagas disease Trypanosoma cruzi Cardiac insufficiency Humans Infection |
title_short |
The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease |
title_full |
The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease |
title_fullStr |
The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease |
title_full_unstemmed |
The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease |
title_sort |
The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease |
author |
Mengel, Jose |
author_facet |
Mengel, Jose Cardillo, Fabíola |
author_role |
author |
author2 |
Cardillo, Fabíola |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Mengel, Jose Cardillo, Fabíola |
dc.subject.other.pt_BR.fl_str_mv |
Doença de Chagas Trypanosoma cruzi Insuficiência cardíaca Humanos Infecção |
topic |
Doença de Chagas Trypanosoma cruzi Insuficiência cardíaca Humanos Infecção Chagas disease Trypanosoma cruzi Cardiac insufficiency Humans Infection |
dc.subject.en.pt_BR.fl_str_mv |
Chagas disease Trypanosoma cruzi Cardiac insufficiency Humans Infection |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Faculty of Medicine of Petrópolis. Petrópolis, RJ, Brazil |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2018-03-20T13:11:33Z |
dc.date.available.fl_str_mv |
2018-03-20T13:11:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MENGEL, J.; CARDILLO, F. The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease. Cellular Immunology and Serum Biology, v. 3, n. 2, p. 120-121, 2017. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/25414 |
dc.identifier.issn.pt_BR.fl_str_mv |
2471-5891 |
identifier_str_mv |
MENGEL, J.; CARDILLO, F. The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease. Cellular Immunology and Serum Biology, v. 3, n. 2, p. 120-121, 2017. 2471-5891 |
url |
https://www.arca.fiocruz.br/handle/icict/25414 |
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eng |
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eng |
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openAccess |
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Ommega Publishers |
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Ommega Publishers |
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Repositório Institucional da FIOCRUZ (ARCA) |
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