Evaluation of results of association of the T.cruzi chemotherapic Benznidazole with others drugs (Nifurtimox, Cetoconazole) in the treatment of the experimental Chagas disease

Detalhes bibliográficos
Autor(a) principal: Almeida, Marcio Cerqueira de
Data de Publicação: 2012
Outros Autores: Andrade, Sonia Gumes
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/23483
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Chagas Experimental Autoimunidade e Imunologia Celular. Salvador, BA, Brasil.
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spelling Almeida, Marcio Cerqueira deAndrade, Sonia Gumes2017-11-30T16:52:21Z2017-11-30T16:52:21Z2012ALMEIDA, Marcio Cerqueira de; ANDRADE, Sonia Gumes. Evaluation of results of association of the T.cruzi chemotherapic Benznidazole with others drugs (Nifurtimox, Cetoconazole) in the treatment of the experimental Chagas disease. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18.; CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012. 1 p.https://www.arca.fiocruz.br/handle/icict/23483engSociedade Brasileira de Medicina TropicalTrypanosoma cruziDoença de ChagasInfecçãoTratamento com drogasHumanosTrypanosoma cruziChagas diseaseInfectionDrug treatmentHumansEvaluation of results of association of the T.cruzi chemotherapic Benznidazole with others drugs (Nifurtimox, Cetoconazole) in the treatment of the experimental Chagas diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Chagas Experimental Autoimunidade e Imunologia Celular. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Chagas Experimental Autoimunidade e Imunologia Celular. Salvador, BA, Brasil.Introduction: Treatment of Chagas disease, determined by infection with Trypanosoma cruzi has been a challenge due to the different susceptibility of the parasite strains, characterized into different biological types or Biodemes. It has been shown that the Benznidazole (BZ) is the drug of choice for the treatment in humans but the results are irregular in patients of different endemic areas. Experimental data have shown a high resistance of the strains of Biodeme type III (T. cruzi I), and irregular results in the treatment of infections with Type II strains (T. cruzi II). The same results were obtained in the treatment with Nifurtimox (NF), in respect to the resistance of different strains. Other drugs in clinical use for different diseases have been assayed experimentally as the case of the Cetoconazole (Ceto). Probably the association of different drugs could improve the results of treatment in humans. Combinations of drugs may shorten the period of treatment and diminish the collateral toxic effects.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23483/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCHag11 Almeida MC Evaluation of... SBMT 2012.pdfCHag11 Almeida MC Evaluation of... SBMT 2012.pdfapplication/pdf80730https://www.arca.fiocruz.br/bitstream/icict/23483/2/CHag11%20Almeida%20MC%20Evaluation%20of...%20SBMT%202012.pdffae54e021901d503cf25de85d3f3a13bMD52TEXTCHag11 Almeida MC Evaluation of... SBMT 2012.pdf.txtCHag11 Almeida MC Evaluation of... 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dc.title.pt_BR.fl_str_mv Evaluation of results of association of the T.cruzi chemotherapic Benznidazole with others drugs (Nifurtimox, Cetoconazole) in the treatment of the experimental Chagas disease
title Evaluation of results of association of the T.cruzi chemotherapic Benznidazole with others drugs (Nifurtimox, Cetoconazole) in the treatment of the experimental Chagas disease
spellingShingle Evaluation of results of association of the T.cruzi chemotherapic Benznidazole with others drugs (Nifurtimox, Cetoconazole) in the treatment of the experimental Chagas disease
Almeida, Marcio Cerqueira de
Trypanosoma cruzi
Doença de Chagas
Infecção
Tratamento com drogas
Humanos
Trypanosoma cruzi
Chagas disease
Infection
Drug treatment
Humans
title_short Evaluation of results of association of the T.cruzi chemotherapic Benznidazole with others drugs (Nifurtimox, Cetoconazole) in the treatment of the experimental Chagas disease
title_full Evaluation of results of association of the T.cruzi chemotherapic Benznidazole with others drugs (Nifurtimox, Cetoconazole) in the treatment of the experimental Chagas disease
title_fullStr Evaluation of results of association of the T.cruzi chemotherapic Benznidazole with others drugs (Nifurtimox, Cetoconazole) in the treatment of the experimental Chagas disease
title_full_unstemmed Evaluation of results of association of the T.cruzi chemotherapic Benznidazole with others drugs (Nifurtimox, Cetoconazole) in the treatment of the experimental Chagas disease
title_sort Evaluation of results of association of the T.cruzi chemotherapic Benznidazole with others drugs (Nifurtimox, Cetoconazole) in the treatment of the experimental Chagas disease
author Almeida, Marcio Cerqueira de
author_facet Almeida, Marcio Cerqueira de
Andrade, Sonia Gumes
author_role author
author2 Andrade, Sonia Gumes
author2_role author
dc.contributor.author.fl_str_mv Almeida, Marcio Cerqueira de
Andrade, Sonia Gumes
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Doença de Chagas
Infecção
Tratamento com drogas
Humanos
topic Trypanosoma cruzi
Doença de Chagas
Infecção
Tratamento com drogas
Humanos
Trypanosoma cruzi
Chagas disease
Infection
Drug treatment
Humans
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Chagas disease
Infection
Drug treatment
Humans
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Chagas Experimental Autoimunidade e Imunologia Celular. Salvador, BA, Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2017-11-30T16:52:21Z
dc.date.available.fl_str_mv 2017-11-30T16:52:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ALMEIDA, Marcio Cerqueira de; ANDRADE, Sonia Gumes. Evaluation of results of association of the T.cruzi chemotherapic Benznidazole with others drugs (Nifurtimox, Cetoconazole) in the treatment of the experimental Chagas disease. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18.; CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012. 1 p.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/23483
identifier_str_mv ALMEIDA, Marcio Cerqueira de; ANDRADE, Sonia Gumes. Evaluation of results of association of the T.cruzi chemotherapic Benznidazole with others drugs (Nifurtimox, Cetoconazole) in the treatment of the experimental Chagas disease. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18.; CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012. 1 p.
url https://www.arca.fiocruz.br/handle/icict/23483
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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