Molecular and biological diversity of HIV-1 in Brazil.

Detalhes bibliográficos
Autor(a) principal: Fernandez, José Carlos Couto
Data de Publicação: 1992
Outros Autores: Morgado, Mariza Gonçalves, Santos, Jairo Ivo dos, Castro Filho, Bernardo Galvão
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5708
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Fernandez, José Carlos CoutoMorgado, Mariza GonçalvesSantos, Jairo Ivo dosCastro Filho, Bernardo Galvão2012-10-22T19:08:59Z2012-10-22T19:08:59Z1992COUTO-FERNANDEZ, J.C. et al. Molecular and biological diversity of HIV-1 in Brazil. Memórias do Instituto Oswaldo Cruz, v. 87, n. 2, p. 249-55, apr.-jun. 1992.0074-0276https://www.arca.fiocruz.br/handle/icict/5708engMolecular and biological diversity of HIV-1 in Brazil.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilTo determine the genomic polymorphism and biological properties present in HIV-1 Brazilian isolates, we analyzed five viral isolates obtained from patients residing in Rio de Janeiro (P1 and P5), São Paulo (P3) and Bahia (P2 and P4) states. For each viral isolate in vitro characteristics such as replication rate, syncytium-inducing capacity and cell death were observed in lymphoblastoid (H9, CEM and peripheral blood mononuclear cells) as well as monocytoid (U937) cells. In addition, the evaluation of the restriction fragment length polymorphism of these isolates was also performed using a panel of endonucleases such as Hind III, Bgl II, Sac I, Pst I, Kpn I and Eco RI. One of the isolates (P1), showed the highest phenotypic and genotypic divergence, when compared to others. The results found suggest a HIV heterogeneity in Brazil similar to that already described in other regions of the world.Brazilian HIVVirulenceRestriction analysisViral diversityDNA Viral/análiseVariação GenéticaHIV-1/genéticaSíndrome de ImunodeficiênciaAdquirida/microbiologiaBrasilHIV-1/patogenicidadeHumanosMasculinoPolimorfismo GenéticoPolimorfismo de Fragmento de RestriçãoMapeamento por RestriçãoVirulênciainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCouto-Fernandes JC Molecular and biological ....pdfCouto-Fernandes JC Molecular and biological ....pdfapplication/pdf353616https://www.arca.fiocruz.br/bitstream/icict/5708/1/Couto-Fernandes%20JC%20Molecular%20and%20biological%20....pdfd613ed7fa2e770cdea12fb1f199f89dbMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5708/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTCouto-Fernandes JC Molecular and biological ....pdf.txtCouto-Fernandes JC Molecular and biological ....pdf.txtExtracted texttext/plain7https://www.arca.fiocruz.br/bitstream/icict/5708/5/Couto-Fernandes%20JC%20Molecular%20and%20biological%20....pdf.txt212b0306580d4f0044d18f9a3edcc832MD55THUMBNAILCouto-Fernandes JC Molecular and biological ....pdf.jpgCouto-Fernandes JC Molecular and biological ....pdf.jpgGenerated Thumbnailimage/jpeg2332https://www.arca.fiocruz.br/bitstream/icict/5708/4/Couto-Fernandes%20JC%20Molecular%20and%20biological%20....pdf.jpg112563bea8fd3bfdec4a704c935ecf0dMD54icict/57082023-03-15 14:32:55.324oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:55Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Molecular and biological diversity of HIV-1 in Brazil.
title Molecular and biological diversity of HIV-1 in Brazil.
spellingShingle Molecular and biological diversity of HIV-1 in Brazil.
Fernandez, José Carlos Couto
Brazilian HIV
Virulence
Restriction analysis
Viral diversity
DNA Viral/análise
Variação Genética
HIV-1/genética
Síndrome de Imunodeficiência
Adquirida/microbiologia
Brasil
HIV-1/patogenicidade
Humanos
Masculino
Polimorfismo Genético
Polimorfismo de Fragmento de Restrição
Mapeamento por Restrição
Virulência
title_short Molecular and biological diversity of HIV-1 in Brazil.
title_full Molecular and biological diversity of HIV-1 in Brazil.
title_fullStr Molecular and biological diversity of HIV-1 in Brazil.
title_full_unstemmed Molecular and biological diversity of HIV-1 in Brazil.
title_sort Molecular and biological diversity of HIV-1 in Brazil.
author Fernandez, José Carlos Couto
author_facet Fernandez, José Carlos Couto
Morgado, Mariza Gonçalves
Santos, Jairo Ivo dos
Castro Filho, Bernardo Galvão
author_role author
author2 Morgado, Mariza Gonçalves
Santos, Jairo Ivo dos
Castro Filho, Bernardo Galvão
author2_role author
author
author
dc.contributor.author.fl_str_mv Fernandez, José Carlos Couto
Morgado, Mariza Gonçalves
Santos, Jairo Ivo dos
Castro Filho, Bernardo Galvão
dc.subject.en.pt_BR.fl_str_mv Brazilian HIV
Virulence
Restriction analysis
Viral diversity
topic Brazilian HIV
Virulence
Restriction analysis
Viral diversity
DNA Viral/análise
Variação Genética
HIV-1/genética
Síndrome de Imunodeficiência
Adquirida/microbiologia
Brasil
HIV-1/patogenicidade
Humanos
Masculino
Polimorfismo Genético
Polimorfismo de Fragmento de Restrição
Mapeamento por Restrição
Virulência
dc.subject.decs.pt_BR.fl_str_mv DNA Viral/análise
Variação Genética
HIV-1/genética
Síndrome de Imunodeficiência
Adquirida/microbiologia
Brasil
HIV-1/patogenicidade
Humanos
Masculino
Polimorfismo Genético
Polimorfismo de Fragmento de Restrição
Mapeamento por Restrição
Virulência
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1992
dc.date.issued.fl_str_mv 1992
dc.date.accessioned.fl_str_mv 2012-10-22T19:08:59Z
dc.date.available.fl_str_mv 2012-10-22T19:08:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv COUTO-FERNANDEZ, J.C. et al. Molecular and biological diversity of HIV-1 in Brazil. Memórias do Instituto Oswaldo Cruz, v. 87, n. 2, p. 249-55, apr.-jun. 1992.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5708
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv COUTO-FERNANDEZ, J.C. et al. Molecular and biological diversity of HIV-1 in Brazil. Memórias do Instituto Oswaldo Cruz, v. 87, n. 2, p. 249-55, apr.-jun. 1992.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/5708
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