Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C

Detalhes bibliográficos
Autor(a) principal: Senff, Tina
Data de Publicação: 2022
Outros Autores: Menne, Christopher, Cosmovici, Christine, Lewis-Ximenez, Lia Laura, Aneja, Jasneet, Broering, Ruth, Kim, Arthur Y., Westendorf, Astrid M., Dittmer, Ulf, Scherbaum, Norbert, Lauer, Georg M., Timm, Jörg
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51040
Resumo: Institute of Virology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Medical Faculty. Düsseldorf, Germany.
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spelling Senff, TinaMenne, ChristopherCosmovici, ChristineLewis-Ximenez, Lia LauraAneja, JasneetBroering, RuthKim, Arthur Y.Westendorf, Astrid M.Dittmer, UlfScherbaum, NorbertLauer, Georg M.Timm, Jörg2022-02-06T13:20:32Z2022-02-06T13:20:32Z2022SENFF, Tina et al. Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C. JCIinsight, v. 7, n. 2, e155432, p. 1 - 15, Jan. 2022.2379-3708https://www.arca.fiocruz.br/handle/icict/5104010.1172/jci. insight.155432.engInsightHepatite CAtivação de células iNKTSangue periféricoDano hepáticoPeripheral bloodiNKT cell activationCorrelateLiver damageAcute hepatitis CPeripheral blood iNKT cell activation correlates with liver damage during acute hepatitis Cinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstitute of Virology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Medical Faculty. Düsseldorf, Germany.Institute of Virology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Medical Faculty. Düsseldorf, Germany.Institute of Virology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Medical Faculty. Düsseldorf, Germany.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School. Boston, Massachusetts, USA.Department of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg-Essen. Essen, Germany.Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston. Massachusetts, USA.Institute of Medical Microbiology. University of Duisburg-Essen. Germany.Institute for Virology, University Hospital Essen. University of Duisburg-Essen, Germany.LVR-Hospital Essen, Department of Addictive Behaviour and Addiction Medicine, Medical Faculty. University of Duisburg- Essen, Essen, Germany.Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School. Boston, Massachusetts, USA.Institute of Virology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Medical Faculty. Düsseldorf, Germany.Invariant NK T (iNKT) cells are implicated in viral clearance; however, their role in hepatitis C virus (HCV) infection remains controversial. Here, iNKT cells were studied during different stages of HCV infection. iNKT cells from patients with acute HCV infection and people who inject drugs (PWID) with chronic or spontaneously resolved HCV infection were characterized by flow cytometry. In a longitudinal analysis during acute HCV infection, frequencies of activated CD38+ iNKT cells reproducibly declined in spontaneously resolving patients, whereas they were persistently elevated in patients progressing to chronic infection. During the first year of infection, the frequency of activated CD38+ or CD69+ iNKT cells strongly correlated with alanine transaminase levels with particularly pronounced correlations in spontaneously resolving patients. Increased frequencies of activated iNKT cells in chronic HCV infection were confirmed in cross-sectional analyses of PWID with chronic or spontaneously resolved HCV infection; however, no apparent functional differences were observed with various stimulation protocols. Our data suggest that iNKT cells are activated during acute hepatitis C and that activation is sustained in chronic infection. The correlation between the frequency of activated iNKT cells and alanine transaminase may point toward a role of iNKT cells in liver damage.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/51040/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLiaLaura_Ximenes_etal_IOC_2022.pdfLiaLaura_Ximenes_etal_IOC_2022.pdfapplication/pdf2617990https://www.arca.fiocruz.br/bitstream/icict/51040/2/LiaLaura_Ximenes_etal_IOC_2022.pdf39da62b2e7558c037357b8dcc6bd7ac8MD52icict/510402022-02-06 10:20:32.297oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-02-06T13:20:32Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C
title Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C
spellingShingle Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C
Senff, Tina
Hepatite C
Ativação de células iNKT
Sangue periférico
Dano hepático
Peripheral blood
iNKT cell activation
Correlate
Liver damage
Acute hepatitis C
title_short Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C
title_full Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C
title_fullStr Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C
title_full_unstemmed Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C
title_sort Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C
author Senff, Tina
author_facet Senff, Tina
Menne, Christopher
Cosmovici, Christine
Lewis-Ximenez, Lia Laura
Aneja, Jasneet
Broering, Ruth
Kim, Arthur Y.
Westendorf, Astrid M.
Dittmer, Ulf
Scherbaum, Norbert
Lauer, Georg M.
Timm, Jörg
author_role author
author2 Menne, Christopher
Cosmovici, Christine
Lewis-Ximenez, Lia Laura
Aneja, Jasneet
Broering, Ruth
Kim, Arthur Y.
Westendorf, Astrid M.
Dittmer, Ulf
Scherbaum, Norbert
Lauer, Georg M.
Timm, Jörg
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Senff, Tina
Menne, Christopher
Cosmovici, Christine
Lewis-Ximenez, Lia Laura
Aneja, Jasneet
Broering, Ruth
Kim, Arthur Y.
Westendorf, Astrid M.
Dittmer, Ulf
Scherbaum, Norbert
Lauer, Georg M.
Timm, Jörg
dc.subject.other.pt_BR.fl_str_mv Hepatite C
Ativação de células iNKT
Sangue periférico
Dano hepático
topic Hepatite C
Ativação de células iNKT
Sangue periférico
Dano hepático
Peripheral blood
iNKT cell activation
Correlate
Liver damage
Acute hepatitis C
dc.subject.en.pt_BR.fl_str_mv Peripheral blood
iNKT cell activation
Correlate
Liver damage
Acute hepatitis C
description Institute of Virology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Medical Faculty. Düsseldorf, Germany.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-02-06T13:20:32Z
dc.date.available.fl_str_mv 2022-02-06T13:20:32Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SENFF, Tina et al. Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C. JCIinsight, v. 7, n. 2, e155432, p. 1 - 15, Jan. 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51040
dc.identifier.issn.pt_BR.fl_str_mv 2379-3708
dc.identifier.doi.none.fl_str_mv 10.1172/jci. insight.155432.
identifier_str_mv SENFF, Tina et al. Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C. JCIinsight, v. 7, n. 2, e155432, p. 1 - 15, Jan. 2022.
2379-3708
10.1172/jci. insight.155432.
url https://www.arca.fiocruz.br/handle/icict/51040
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Insight
publisher.none.fl_str_mv Insight
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51040/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51040/2/LiaLaura_Ximenes_etal_IOC_2022.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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