In vitro and in vivo models for monkeypox

Detalhes bibliográficos
Autor(a) principal: Rosa, Rafael Borges
Data de Publicação: 2019
Outros Autores: Castro, Emilene Ferreira de, Silva, Murilo Vieira da, Ferreira, Denise Caroline Paiva, Jardim, Ana Carolina Gomes, Santos, Igor Andrade, Marinho, Mikaela dos Santos, França, Flávia Batista Ferreira, Pena, Lindomar José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33932
Resumo: Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Department of Virology and Experimental Therapy. Recife, PE, Brazil / Federal University of Uberlândia. Rodents Animal Facilities Complex. Uberlândia, MG, Brazil.
id CRUZ_0d0673bac2e3044683118453d8cd3376
oai_identifier_str oai:www.arca.fiocruz.br:icict/33932
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Rosa, Rafael BorgesCastro, Emilene Ferreira deSilva, Murilo Vieira daFerreira, Denise Caroline PaivaJardim, Ana Carolina GomesSantos, Igor AndradeMarinho, Mikaela dos SantosFrança, Flávia Batista FerreiraPena, Lindomar José2019-07-09T21:28:52Z2019-07-09T21:28:52Z2023ROSA, Rafael Borges et al. n vitro and in vivo models for monkeypox. iScience, v. 26, n. 1, p. 1-44, Jan. 2023.2589-0042https://www.arca.fiocruz.br/handle/icict/3393210.1016/j.isci.2022.1057022589-0042engCell PressIn vitro and in vivo models for monkeypoxinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleOswaldo Cruz Foundation. Aggeu Magalhães Institute. Department of Virology and Experimental Therapy. Recife, PE, Brazil / Federal University of Uberlândia. Rodents Animal Facilities Complex. Uberlândia, MG, Brazil.Federal University of Uberlândia. Rodents Animal Facilities Complex. Uberlândia, MG, Brazil.Federal University of Uberlândia. Rodents Animal Facilities Complex. Uberlândia, MG, Brazil.Federal University of Uberlândia. Rodents Animal Facilities Complex. Uberlândia, MG, Brazil.Federal University of Uberlândia. Institute of Biomedical Sciences. Uberlândia, MG, Brazil.Federal University of Uberlândia. Institute of Biomedical Sciences. Uberlândia, MG, Brazil.Federal University of Uberlândia. Institute of Biomedical Sciences. Uberlândia, MG, Brazil.Federal University of Uberlândia. Institute of Biomedical Sciences. Uberlândia, MG, Brazil.Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Department of Virology and Experimental Therapy. Recife, PE, Brazil.The emergence and rapid spread outside of monkeypox virus (MPXV) to non-endemic areas has led to another global health emergency in the midst of the COVID-19 pandemic. The scientific community has sought to rapidly develop in vitro and in vivo models that could be applied in research with MPXV. In vitro models include two-dimensional (2D) cultures of immortalized cell lines or primary cells and three-dimensional (3D) cultures. In vitro models are considered cost-effective and can be done in highly controlled conditions; however, they do not always resemble physiological conditions. In this way, several in vivo models are being characterized to meet the growing demand for new studies related to MPXV. In this review, we summarize the main MPXV models that have already been developed and discuss how they can contribute to advance the understanding of its pathogenesis, replication, and transmission, as well as identifying antivirals to treat infected patients.VirologyMonkeypox virus (MPXV)Study viral infectionsCellsVirus strainViral cultivationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALRosa_Rafael_etal_IAM_Monkeypox_2023.pdfRosa_Rafael_etal_IAM_Monkeypox_2023.pdfapplication/pdf2536014https://www.arca.fiocruz.br/bitstream/icict/33932/2/Rosa_Rafael_etal_IAM_Monkeypox_2023.pdf28063bcf99449845f6c37dec4306499cMD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/33932/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/339322023-04-04 21:34:45.228oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-04-05T00:34:45Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en-US.fl_str_mv In vitro and in vivo models for monkeypox
title In vitro and in vivo models for monkeypox
spellingShingle In vitro and in vivo models for monkeypox
Rosa, Rafael Borges
Virology
Monkeypox virus (MPXV)
Study viral infections
Cells
Virus strain
Viral cultivation
title_short In vitro and in vivo models for monkeypox
title_full In vitro and in vivo models for monkeypox
title_fullStr In vitro and in vivo models for monkeypox
title_full_unstemmed In vitro and in vivo models for monkeypox
title_sort In vitro and in vivo models for monkeypox
author Rosa, Rafael Borges
author_facet Rosa, Rafael Borges
Castro, Emilene Ferreira de
Silva, Murilo Vieira da
Ferreira, Denise Caroline Paiva
Jardim, Ana Carolina Gomes
Santos, Igor Andrade
Marinho, Mikaela dos Santos
França, Flávia Batista Ferreira
Pena, Lindomar José
author_role author
author2 Castro, Emilene Ferreira de
Silva, Murilo Vieira da
Ferreira, Denise Caroline Paiva
Jardim, Ana Carolina Gomes
Santos, Igor Andrade
Marinho, Mikaela dos Santos
França, Flávia Batista Ferreira
Pena, Lindomar José
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rosa, Rafael Borges
Castro, Emilene Ferreira de
Silva, Murilo Vieira da
Ferreira, Denise Caroline Paiva
Jardim, Ana Carolina Gomes
Santos, Igor Andrade
Marinho, Mikaela dos Santos
França, Flávia Batista Ferreira
Pena, Lindomar José
dc.subject.en.none.fl_str_mv Virology
Monkeypox virus (MPXV)
Study viral infections
Cells
Virus strain
Viral cultivation
topic Virology
Monkeypox virus (MPXV)
Study viral infections
Cells
Virus strain
Viral cultivation
description Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Department of Virology and Experimental Therapy. Recife, PE, Brazil / Federal University of Uberlândia. Rodents Animal Facilities Complex. Uberlândia, MG, Brazil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-07-09T21:28:52Z
dc.date.available.fl_str_mv 2019-07-09T21:28:52Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ROSA, Rafael Borges et al. n vitro and in vivo models for monkeypox. iScience, v. 26, n. 1, p. 1-44, Jan. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33932
dc.identifier.issn.pt_BR.fl_str_mv 2589-0042
dc.identifier.doi.none.fl_str_mv 10.1016/j.isci.2022.105702
dc.identifier.eissn.none.fl_str_mv 2589-0042
identifier_str_mv ROSA, Rafael Borges et al. n vitro and in vivo models for monkeypox. iScience, v. 26, n. 1, p. 1-44, Jan. 2023.
2589-0042
10.1016/j.isci.2022.105702
url https://www.arca.fiocruz.br/handle/icict/33932
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/33932/2/Rosa_Rafael_etal_IAM_Monkeypox_2023.pdf
https://www.arca.fiocruz.br/bitstream/icict/33932/1/license.txt
bitstream.checksum.fl_str_mv 28063bcf99449845f6c37dec4306499c
8a4605be74aa9ea9d79846c1fba20a33
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813008957370793984

Registros relacionados