Post-cART progressive multifocal leukoencephalopathy era in a Brazilian center

Detalhes bibliográficos
Autor(a) principal: Lima, Marco A.
Data de Publicação: 2017
Outros Autores: Silva, Tulius T. Silva, Afonso, Livia A., Vaz, Beatriz J. P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34618
Resumo: 2020-08-06
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spelling Lima, Marco A.Silva, Tulius T. SilvaAfonso, Livia A.Vaz, Beatriz J. P.2019-08-06T13:35:12Z2019-08-06T13:35:12Z2017LIMA, Marco A. et al. Post-cART progressive multifocal leukoencephalopathy era in a Brazilian center. Journal of the Neurological Sciences, v. 381, p. 321-324, 2017.0022-510Xhttps://www.arca.fiocruz.br/handle/icict/3461810.1016/j.jns.2017.09.0021878-5883engElsevierPost-cART progressive multifocal leukoencephalopathy era in a Brazilian centerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-08-06Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil / Federal University of Rio de Janeiro. Neurology Service. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratory of Viral Pathogenesis. Rio de Janeiro, RJ, Brasil.Federal University of Rio de Janeiro. Neurology Service. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratory of Viral Pathogenesis. Rio de Janeiro, RJ, Brasil.Progressive multifocal leukoencephalopathy (PML) is lytic infection of oligodendrocytes caused by JC virus (JCV). While PML incidence in developing countries has decreased after the introduction of combination antiretroviral therapy (cART), data in developing countries is scarce and limited to few cohorts. We described the epidemiological and clinical profile of a group of Brazilian HIV infected patients with PML in the cART era. A total of 27 patients were included in the study. The median age at PML onset was 42 years (range: 27–67 years) and 18 (66.7%) were men. The median CD4 + T cell count at the time of diagnosis was 67cells/mm3 and the median HIV viral load was 27,000 copies/ml. Motor deficits were the most common early manifestations (44%). Seizures occurred in 37% of the patients and 9 (33.3%) had PML associated with immune reconstitution inflammatory syndrome (IRIS). Mortality was 33% and lower age at PML onset was associated with survival (p: 0.013). Our results are in accordance with previous published series of PML cases. Factors such as genetic background, regional JCV subtype differences, death from other diseases and underdiagnosis may explain the low prevalence of reported PML cases in developing countries.HIVLeukoencephalopathyProgressive multifocalAntiretroviral therapyHighly activeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/34618/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Lima_Marco_etal_INI_2017.pdfve_Lima_Marco_etal_INI_2017.pdfapplication/pdf146162https://www.arca.fiocruz.br/bitstream/icict/34618/2/ve_Lima_Marco_etal_INI_2017.pdfc82444729f8ac9d4689d26b2e3f9a94eMD52TEXTve_Lima_Marco_etal_INI_2017.pdf.txtve_Lima_Marco_etal_INI_2017.pdf.txtExtracted texttext/plain21554https://www.arca.fiocruz.br/bitstream/icict/34618/3/ve_Lima_Marco_etal_INI_2017.pdf.txt457c5d7ab41e2203de4d8cba345ca422MD53icict/346182021-03-24 16:32:34.984oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:34Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Post-cART progressive multifocal leukoencephalopathy era in a Brazilian center
title Post-cART progressive multifocal leukoencephalopathy era in a Brazilian center
spellingShingle Post-cART progressive multifocal leukoencephalopathy era in a Brazilian center
Lima, Marco A.
HIV
Leukoencephalopathy
Progressive multifocal
Antiretroviral therapy
Highly active
title_short Post-cART progressive multifocal leukoencephalopathy era in a Brazilian center
title_full Post-cART progressive multifocal leukoencephalopathy era in a Brazilian center
title_fullStr Post-cART progressive multifocal leukoencephalopathy era in a Brazilian center
title_full_unstemmed Post-cART progressive multifocal leukoencephalopathy era in a Brazilian center
title_sort Post-cART progressive multifocal leukoencephalopathy era in a Brazilian center
author Lima, Marco A.
author_facet Lima, Marco A.
Silva, Tulius T. Silva
Afonso, Livia A.
Vaz, Beatriz J. P.
author_role author
author2 Silva, Tulius T. Silva
Afonso, Livia A.
Vaz, Beatriz J. P.
author2_role author
author
author
dc.contributor.author.fl_str_mv Lima, Marco A.
Silva, Tulius T. Silva
Afonso, Livia A.
Vaz, Beatriz J. P.
dc.subject.en.pt_BR.fl_str_mv HIV
Leukoencephalopathy
Progressive multifocal
Antiretroviral therapy
Highly active
topic HIV
Leukoencephalopathy
Progressive multifocal
Antiretroviral therapy
Highly active
description 2020-08-06
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2019-08-06T13:35:12Z
dc.date.available.fl_str_mv 2019-08-06T13:35:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LIMA, Marco A. et al. Post-cART progressive multifocal leukoencephalopathy era in a Brazilian center. Journal of the Neurological Sciences, v. 381, p. 321-324, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34618
dc.identifier.issn.pt_BR.fl_str_mv 0022-510X
dc.identifier.doi.none.fl_str_mv 10.1016/j.jns.2017.09.002
dc.identifier.eissn.none.fl_str_mv 1878-5883
identifier_str_mv LIMA, Marco A. et al. Post-cART progressive multifocal leukoencephalopathy era in a Brazilian center. Journal of the Neurological Sciences, v. 381, p. 321-324, 2017.
0022-510X
10.1016/j.jns.2017.09.002
1878-5883
url https://www.arca.fiocruz.br/handle/icict/34618
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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