Highly active antiretroviral therapy and progressive multifocal leukoencephalopathy:effect on cerebrospinal fluid markers of JC virus replication and immune response

Detalhes bibliográficos
Autor(a) principal: Giudici, B.
Data de Publicação: 2000
Outros Autores: Vaz, B., Bossolasco, S., Casari, S., Brambilla, A., Luke, W., Lazzarin, A., Weber, T., Cinque, P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42481
Resumo: San Raffaele Hospital. Division of Infectious Diseases. Milan, Italy.
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spelling Giudici, B.Vaz, B.Bossolasco, S.Casari, S.Brambilla, A.Luke, W.Lazzarin, A.Weber, T.Cinque, P.2020-07-31T00:21:25Z2020-07-31T00:21:25Z2000GIUDICI, B. et al. Highly active antiretroviral therapy and progressive multifocal leukoencephalopathy: effects on cerebrospinal fluid markers of JC virus replication and immune response. Clinical Infectious Diseases, v. 30, n. 1, p. 95-99, 2000.1058-4838https://www.arca.fiocruz.br/handle/icict/4248110.1086/313598engOxfordHighly active antiretroviral therapy and progressive multifocal leukoencephalopathy:effect on cerebrospinal fluid markers of JC virus replication and immune responseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSan Raffaele Hospital. Division of Infectious Diseases. Milan, Italy.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Neurology Clinic. Marienkrankenhausen, Hamburg, Germany.San Raffaele Hospital. Division of Infectious Diseases. Milan, Italy.Clinic of Infectious Diseases. Spedali Civili, Brescia, Italy.San Raffaele Hospital. Division of Infectious Diseases. Milan, Italy.German Primate Center. Department of Virology and Immunology. Go¨ttingen, Germany.San Raffaele Hospital. Division of Infectious Diseases. Milan, Italy.Neurology Clinic. Marienkrankenhausen, Hamburg, Germany.San Raffaele Hospital. Division of Infectious Diseases. Milan, Italy.Cerebrospinal fluid (CSF) samples were examined from 7 patients infected with human immunodeficiency virus type 1 (HIV-1) who had progressive multifocal leukoencephalopathy (PML). Samples were obtained both before and after 35-365 days of highly active antiretroviral therapy (HAART). By polymerase chain reaction, JC virus (JCV) DNA was found in 6 of 7 patients at baseline but in only 1 patient after HAART. In contrast, in 25 historical control patients from whom sequential CSF specimens were obtained, no reversion from detectable to undetectable JCV DNA was observed. By use of enzyme-linked immunosorbent assay, intrathecal production of antibody to JCV-VP1 was shown in only 1 of 4 HAART recipients at baseline but in 5 of 5 patients after treatment. The neuroradiological picture improved or had stabilized in all patients after 12 months of HAART, and all were alive after a median of 646 days (range, 505-775 days). Prolonged survival after HAART for PML is associated with JCV clearance from CSF. JCV-specific humoral intrathecal immunity may play a role in this response.Polymerase chain reactionImmune responseAntiretroviral therapyHighly activeDrug clearanceDNAHiv-1jc virusProgressive multifocal leukoencephalopathyCerebrospinal fluidinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/42481/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALHighly_Beatriz_Vaz_etal_INI_2000.pdfHighly_Beatriz_Vaz_etal_INI_2000.pdfapplication/pdf131533https://www.arca.fiocruz.br/bitstream/icict/42481/2/Highly_Beatriz_Vaz_etal_INI_2000.pdf8b1b1d9a21386b4da29f9fac905dbf4cMD52TEXTHighly_Beatriz_Vaz_etal_INI_2000.pdf.txtHighly_Beatriz_Vaz_etal_INI_2000.pdf.txtExtracted texttext/plain25780https://www.arca.fiocruz.br/bitstream/icict/42481/3/Highly_Beatriz_Vaz_etal_INI_2000.pdf.txtf5d034ab63691cffc01274da198b7e8bMD53icict/424812020-07-31 02:08:26.153oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352020-07-31T05:08:26Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Highly active antiretroviral therapy and progressive multifocal leukoencephalopathy:effect on cerebrospinal fluid markers of JC virus replication and immune response
title Highly active antiretroviral therapy and progressive multifocal leukoencephalopathy:effect on cerebrospinal fluid markers of JC virus replication and immune response
spellingShingle Highly active antiretroviral therapy and progressive multifocal leukoencephalopathy:effect on cerebrospinal fluid markers of JC virus replication and immune response
Giudici, B.
Polymerase chain reaction
Immune response
Antiretroviral therapy
Highly active
Drug clearance
DNA
Hiv-1
jc virus
Progressive multifocal leukoencephalopathy
Cerebrospinal fluid
title_short Highly active antiretroviral therapy and progressive multifocal leukoencephalopathy:effect on cerebrospinal fluid markers of JC virus replication and immune response
title_full Highly active antiretroviral therapy and progressive multifocal leukoencephalopathy:effect on cerebrospinal fluid markers of JC virus replication and immune response
title_fullStr Highly active antiretroviral therapy and progressive multifocal leukoencephalopathy:effect on cerebrospinal fluid markers of JC virus replication and immune response
title_full_unstemmed Highly active antiretroviral therapy and progressive multifocal leukoencephalopathy:effect on cerebrospinal fluid markers of JC virus replication and immune response
title_sort Highly active antiretroviral therapy and progressive multifocal leukoencephalopathy:effect on cerebrospinal fluid markers of JC virus replication and immune response
author Giudici, B.
author_facet Giudici, B.
Vaz, B.
Bossolasco, S.
Casari, S.
Brambilla, A.
Luke, W.
Lazzarin, A.
Weber, T.
Cinque, P.
author_role author
author2 Vaz, B.
Bossolasco, S.
Casari, S.
Brambilla, A.
Luke, W.
Lazzarin, A.
Weber, T.
Cinque, P.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Giudici, B.
Vaz, B.
Bossolasco, S.
Casari, S.
Brambilla, A.
Luke, W.
Lazzarin, A.
Weber, T.
Cinque, P.
dc.subject.en.pt_BR.fl_str_mv Polymerase chain reaction
Immune response
Antiretroviral therapy
Highly active
Drug clearance
DNA
Hiv-1
jc virus
Progressive multifocal leukoencephalopathy
Cerebrospinal fluid
topic Polymerase chain reaction
Immune response
Antiretroviral therapy
Highly active
Drug clearance
DNA
Hiv-1
jc virus
Progressive multifocal leukoencephalopathy
Cerebrospinal fluid
description San Raffaele Hospital. Division of Infectious Diseases. Milan, Italy.
publishDate 2000
dc.date.issued.fl_str_mv 2000
dc.date.accessioned.fl_str_mv 2020-07-31T00:21:25Z
dc.date.available.fl_str_mv 2020-07-31T00:21:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GIUDICI, B. et al. Highly active antiretroviral therapy and progressive multifocal leukoencephalopathy: effects on cerebrospinal fluid markers of JC virus replication and immune response. Clinical Infectious Diseases, v. 30, n. 1, p. 95-99, 2000.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42481
dc.identifier.issn.pt_BR.fl_str_mv 1058-4838
dc.identifier.doi.none.fl_str_mv 10.1086/313598
identifier_str_mv GIUDICI, B. et al. Highly active antiretroviral therapy and progressive multifocal leukoencephalopathy: effects on cerebrospinal fluid markers of JC virus replication and immune response. Clinical Infectious Diseases, v. 30, n. 1, p. 95-99, 2000.
1058-4838
10.1086/313598
url https://www.arca.fiocruz.br/handle/icict/42481
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Oxford
publisher.none.fl_str_mv Oxford
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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