Early mortality and cause of deaths in patients using HAART in Brazil and the United States

Detalhes bibliográficos
Autor(a) principal: Grinsztejn, Beatriz
Data de Publicação: 2009
Outros Autores: Santos, Valdiléa Gonçalves Veloso dos, Friedman, Ruth K, Moreira, Ronaldo I, Luz, Paula Mendes, Campos, Dayse P, Pilotto, José H, Cardoso, Sandra W, Keruly, Jeanne C, Moore, Richard D
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30291
Resumo: Acknowledgements: B.G. acknowledges funding from the National Counsel of Technological and Scientific Development (CNPq) and the Research Funding Agency of the State of Rio de Janeiro (FAPERJ). R.M. acknowledges funding from National Institutes of Health (NIH): R01 DA11602, R01 AA18693, K24 DA00432. B.G., V.G.V. and R.D.M. conceived, designed, and coordinated the study, guided the discussion of the results, and drafted the manuscript. R.D.M. conducted the data analysis. D.P.C. and R.I.M. were responsible for data collection in Rio de Janeiro and participated in the discussion of the results. R.D.M. and J.C.K. were responsible for the data collection in Baltimore. R.K.F. and P.M.L. participated in the study design, discussion of the results, and in the writing of the manuscript. J.C.K., J.H.P. and S.W.C. participated in the study design and in the discussion of the results.
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spelling Grinsztejn, BeatrizSantos, Valdiléa Gonçalves Veloso dosFriedman, Ruth KMoreira, Ronaldo ILuz, Paula MendesCampos, Dayse PPilotto, José HCardoso, Sandra WKeruly, Jeanne CMoore, Richard D2018-11-28T18:27:00Z2018-11-28T18:27:00Z2009GRINSZTEJN, Beatriz et al. Early mortality and cause of deaths in patients using HAART in Brazil and the United States. AIDS, v. 23, n. 16, p. 2107-2114, 2009.1473-5571https://www.arca.fiocruz.br/handle/icict/3029110.1097/QAD.0b013e32832ec494Acknowledgements: B.G. acknowledges funding from the National Counsel of Technological and Scientific Development (CNPq) and the Research Funding Agency of the State of Rio de Janeiro (FAPERJ). R.M. acknowledges funding from National Institutes of Health (NIH): R01 DA11602, R01 AA18693, K24 DA00432. B.G., V.G.V. and R.D.M. conceived, designed, and coordinated the study, guided the discussion of the results, and drafted the manuscript. R.D.M. conducted the data analysis. D.P.C. and R.I.M. were responsible for data collection in Rio de Janeiro and participated in the discussion of the results. R.D.M. and J.C.K. were responsible for the data collection in Baltimore. R.K.F. and P.M.L. participated in the study design, discussion of the results, and in the writing of the manuscript. J.C.K., J.H.P. and S.W.C. participated in the study design and in the discussion of the results.B.G. acknowledges funding from the National Counsel of Technological and Scientific Development (CNPq) and the Research Funding Agency of the State of Rio de Janeiro (FAPERJ). R.M. acknowledges funding from National Institutes of Health (NIH): R01 DA11602, R01 AA18693, K24 DA00432.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Johns Hopkins University. Department of Medicine. Baltimore, Maryland, United States.Johns Hopkins University. Department of Medicine. Baltimore, Maryland, United States.Objective: To compare the early mortality pattern and causes of death among patients starting HAART in Brazil and the United States. Methods: We analyzed the combined data from two clinical cohorts followed at the Johns Hopkins AIDS Service in Baltimore, United States, and the Evandro Chagas Clinical Research Institute AIDS Clinic in Rio de Janeiro, Brazil. Participants included those who entered either cohort between 1999 and 2007 and were antiretroviral naive. Follow-up was at 1 year since HAART initiation. Cox proportional hazards regression analysis was used to assess the role of the city on the risk of death. Results: A total of 859 and 915 participants from Baltimore and Rio de Janeiro, respectively, were included. In Rio de Janeiro, 64.7% of deaths occurred within 90 days of HAART initiation; in Baltimore, 48.9% occurred between 180 and 365 days. AIDS-defining illness (61.8%) and non-AIDS-defining illness (55.6%) predominated as causes of death in Rio de Janeiro and Baltimore, respectively. Risk of death was similar in both cities (hazard ratio 1.04; P value = 0.95) after adjusting for CD4 T cell count, age, sex, HIV risk group, prior AIDS-defining illness, and Pneumocystis jirovecii pneumonia and Mycobacterium avium prophylaxis. Individuals with CD4 T cell count less than or equal to 50 cells/microl (hazard ratio 4.36; P = 0.001) or older (hazard ratio, 1.03; P = 0.03) were more likely to die. Conclusion: Although late HIV diagnosis is a problem both in developed and developing countries, differences in the timing and causes of deaths clearly indicate that, besides interventions for early HIV diagnosis, different strategies to curb early mortality need to be tailored in each country.engEarly mortality and cause of deaths in patients using HAART in Brazil and the United Statesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAntiretroviral therapyCauses of deathCohortEarly mortalityHIV/AIDSinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/30291/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALEarly mortality and cause of deaths_Beatriz_Grinsztejn_INI_Lapclin-AIDS_2009.pdfEarly mortality and cause of 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dc.title.pt_BR.fl_str_mv Early mortality and cause of deaths in patients using HAART in Brazil and the United States
title Early mortality and cause of deaths in patients using HAART in Brazil and the United States
spellingShingle Early mortality and cause of deaths in patients using HAART in Brazil and the United States
Grinsztejn, Beatriz
Antiretroviral therapy
Causes of death
Cohort
Early mortality
HIV/AIDS
title_short Early mortality and cause of deaths in patients using HAART in Brazil and the United States
title_full Early mortality and cause of deaths in patients using HAART in Brazil and the United States
title_fullStr Early mortality and cause of deaths in patients using HAART in Brazil and the United States
title_full_unstemmed Early mortality and cause of deaths in patients using HAART in Brazil and the United States
title_sort Early mortality and cause of deaths in patients using HAART in Brazil and the United States
author Grinsztejn, Beatriz
author_facet Grinsztejn, Beatriz
Santos, Valdiléa Gonçalves Veloso dos
Friedman, Ruth K
Moreira, Ronaldo I
Luz, Paula Mendes
Campos, Dayse P
Pilotto, José H
Cardoso, Sandra W
Keruly, Jeanne C
Moore, Richard D
author_role author
author2 Santos, Valdiléa Gonçalves Veloso dos
Friedman, Ruth K
Moreira, Ronaldo I
Luz, Paula Mendes
Campos, Dayse P
Pilotto, José H
Cardoso, Sandra W
Keruly, Jeanne C
Moore, Richard D
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Grinsztejn, Beatriz
Santos, Valdiléa Gonçalves Veloso dos
Friedman, Ruth K
Moreira, Ronaldo I
Luz, Paula Mendes
Campos, Dayse P
Pilotto, José H
Cardoso, Sandra W
Keruly, Jeanne C
Moore, Richard D
dc.subject.en.pt_BR.fl_str_mv Antiretroviral therapy
Causes of death
Cohort
Early mortality
HIV/AIDS
topic Antiretroviral therapy
Causes of death
Cohort
Early mortality
HIV/AIDS
description Acknowledgements: B.G. acknowledges funding from the National Counsel of Technological and Scientific Development (CNPq) and the Research Funding Agency of the State of Rio de Janeiro (FAPERJ). R.M. acknowledges funding from National Institutes of Health (NIH): R01 DA11602, R01 AA18693, K24 DA00432. B.G., V.G.V. and R.D.M. conceived, designed, and coordinated the study, guided the discussion of the results, and drafted the manuscript. R.D.M. conducted the data analysis. D.P.C. and R.I.M. were responsible for data collection in Rio de Janeiro and participated in the discussion of the results. R.D.M. and J.C.K. were responsible for the data collection in Baltimore. R.K.F. and P.M.L. participated in the study design, discussion of the results, and in the writing of the manuscript. J.C.K., J.H.P. and S.W.C. participated in the study design and in the discussion of the results.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2018-11-28T18:27:00Z
dc.date.available.fl_str_mv 2018-11-28T18:27:00Z
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dc.identifier.citation.fl_str_mv GRINSZTEJN, Beatriz et al. Early mortality and cause of deaths in patients using HAART in Brazil and the United States. AIDS, v. 23, n. 16, p. 2107-2114, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30291
dc.identifier.issn.pt_BR.fl_str_mv 1473-5571
dc.identifier.doi.none.fl_str_mv 10.1097/QAD.0b013e32832ec494
identifier_str_mv GRINSZTEJN, Beatriz et al. Early mortality and cause of deaths in patients using HAART in Brazil and the United States. AIDS, v. 23, n. 16, p. 2107-2114, 2009.
1473-5571
10.1097/QAD.0b013e32832ec494
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