Detection and characterization of hepatitis E virus genotype 3 in HIV-infected patients and blood donors from southern Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1016/j.ijid.2019.06.027 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40583 |
Resumo: | Universidade Federal do Rio Grande. Escola de Medicina. Rio Grande, RS, Brasil. |
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Silva, Cláudio Moss daOliveira, Jaqueline MendesMendoza-Sassi, Raúl AndrésFigueiredo, Andreza SorianoMota, Luís Dias daNader, Maíba MikhaelGardinali, Noemi RovarisKevorkian, Yohan BrittoSalvador, Sarah Beatriz SalamenePinto, Marcelo AlvesMarinez, Ana Maria Barral2020-03-31T18:27:23Z2020-03-31T18:27:23Z2019SILVA, Cláudio Moss da et al. Detection and characterization of hepatitis E virus genotype 3 in HIV-infected patients and blood donors from southern Brazil. International Journal of Infectious Diseases, v. 86, p. 114-121, 2019.1201-9712https://www.arca.fiocruz.br/handle/icict/4058310.1016/j.ijid.2019.06.0271878-3511engElsevierVírus da Hepatite ESoroprevalênciaHIVDoadores de sangueHepatitis E virusHEVSeroprevalenceBlood donorsHIVDetection and characterization of hepatitis E virus genotype 3 in HIV-infected patients and blood donors from southern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio Grande. Escola de Medicina. Rio Grande, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande. Escola de Medicina. Rio Grande, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande. Escola de Medicina. Rio Grande, RS, Brasil.Universidade Federal do Rio Grande. Hospital Universitário. Rio Grande, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande. Escola de Medicina. Rio Grande, RS, Brasil.Background: Hepatitis E virus genotype 3 (HEV-3) infection usually causes self-limited acute hepatitis. In immunosuppressed patients, HEV-3 infection can rapidly progress to chronic hepatitis and cirrhosis. In southern Brazil, data on HEV seroprevalence are scarce. Methods: Testing for HEV RNA and antibodies (anti-HEV) was performed for 320 HIV-infected patients followed at the HIV/AIDS Service of the Federal University of Rio Grande between 2012 and 2013, as well as 281 blood donor samples obtained in 2015. Variables associated with anti-HEV positivity were assessed by multivariable logistic regression analysis. Results: HIV and blood donor groups showed similar HEV seroprevalence (6.7% and 7.1%, respectively). Risk factors associated with anti-HEV detection were older age, marital status, a higher number of sexual partners, poor sanitation, and alcohol use (HIV group), and living in a rural area (blood donors). HEV RNA was detected in eight serum samples from HIV-infected patients and in one blood donor, who was also positive for anti-HEV IgM and IgG. Conclusions: The prevalence rates of HEV infection were comparable between HIV-seropositive patients who were not severely immunocompromised and blood donors. The blood donor’s HEV isolate showed high similarity with swine HEV strains from Brazilian herds in the same region,thus indicating a potential risk of foodborne and parenteral transmission via blood transfusion.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40583/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMarceloAPInto_AndrezaSFigueiredo_etal_IOC_2019.pdfMarceloAPInto_AndrezaSFigueiredo_etal_IOC_2019.pdfapplication/pdf610422https://www.arca.fiocruz.br/bitstream/icict/40583/2/MarceloAPInto_AndrezaSFigueiredo_etal_IOC_2019.pdf77e9d0d5a4e90871829997097e67628cMD52TEXTMarceloAPInto_AndrezaSFigueiredo_etal_IOC_2019.pdf.txtMarceloAPInto_AndrezaSFigueiredo_etal_IOC_2019.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Detection and characterization of hepatitis E virus genotype 3 in HIV-infected patients and blood donors from southern Brazil |
| title |
Detection and characterization of hepatitis E virus genotype 3 in HIV-infected patients and blood donors from southern Brazil |
| spellingShingle |
Detection and characterization of hepatitis E virus genotype 3 in HIV-infected patients and blood donors from southern Brazil Silva, Cláudio Moss da Vírus da Hepatite E Soroprevalência HIV Doadores de sangue Hepatitis E virus HEV Seroprevalence Blood donors HIV |
| title_short |
Detection and characterization of hepatitis E virus genotype 3 in HIV-infected patients and blood donors from southern Brazil |
| title_full |
Detection and characterization of hepatitis E virus genotype 3 in HIV-infected patients and blood donors from southern Brazil |
| title_fullStr |
Detection and characterization of hepatitis E virus genotype 3 in HIV-infected patients and blood donors from southern Brazil |
| title_full_unstemmed |
Detection and characterization of hepatitis E virus genotype 3 in HIV-infected patients and blood donors from southern Brazil |
| title_sort |
Detection and characterization of hepatitis E virus genotype 3 in HIV-infected patients and blood donors from southern Brazil |
| author |
Silva, Cláudio Moss da |
| author_facet |
Silva, Cláudio Moss da Oliveira, Jaqueline Mendes Mendoza-Sassi, Raúl Andrés Figueiredo, Andreza Soriano Mota, Luís Dias da Nader, Maíba Mikhael Gardinali, Noemi Rovaris Kevorkian, Yohan Britto Salvador, Sarah Beatriz Salamene Pinto, Marcelo Alves Marinez, Ana Maria Barral |
| author_role |
author |
| author2 |
Oliveira, Jaqueline Mendes Mendoza-Sassi, Raúl Andrés Figueiredo, Andreza Soriano Mota, Luís Dias da Nader, Maíba Mikhael Gardinali, Noemi Rovaris Kevorkian, Yohan Britto Salvador, Sarah Beatriz Salamene Pinto, Marcelo Alves Marinez, Ana Maria Barral |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Cláudio Moss da Oliveira, Jaqueline Mendes Mendoza-Sassi, Raúl Andrés Figueiredo, Andreza Soriano Mota, Luís Dias da Nader, Maíba Mikhael Gardinali, Noemi Rovaris Kevorkian, Yohan Britto Salvador, Sarah Beatriz Salamene Pinto, Marcelo Alves Marinez, Ana Maria Barral |
| dc.subject.other.pt_BR.fl_str_mv |
Vírus da Hepatite E Soroprevalência HIV Doadores de sangue |
| topic |
Vírus da Hepatite E Soroprevalência HIV Doadores de sangue Hepatitis E virus HEV Seroprevalence Blood donors HIV |
| dc.subject.en.pt_BR.fl_str_mv |
Hepatitis E virus HEV Seroprevalence Blood donors HIV |
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Universidade Federal do Rio Grande. Escola de Medicina. Rio Grande, RS, Brasil. |
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2019 |
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2019 |
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2020-03-31T18:27:23Z |
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2020-03-31T18:27:23Z |
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SILVA, Cláudio Moss da et al. Detection and characterization of hepatitis E virus genotype 3 in HIV-infected patients and blood donors from southern Brazil. International Journal of Infectious Diseases, v. 86, p. 114-121, 2019. |
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https://www.arca.fiocruz.br/handle/icict/40583 |
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1201-9712 |
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10.1016/j.ijid.2019.06.027 |
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1878-3511 |
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SILVA, Cláudio Moss da et al. Detection and characterization of hepatitis E virus genotype 3 in HIV-infected patients and blood donors from southern Brazil. International Journal of Infectious Diseases, v. 86, p. 114-121, 2019. 1201-9712 10.1016/j.ijid.2019.06.027 1878-3511 |
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