Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers

Santos, Letícia Adrielle dos; Góis Filho, Pedro Germano de; Silva, Ana Maria Fantini; Santos, João Victor Gomes; Santos, Douglas Siqueira; Aquino, Marília Marques; Jesus, Rafaela Mota de; Almeida, Maria Luiza Dória; Silva, João Santana da; Altmann, Daniel M.; Boyton, Rosemary J.; Santos, Cliomar Alves dos; Santos, Camilla Natália Oliveira; Alves, Juliana Cardoso; Santos, Ianaline Lima; Magalhães, Lucas Sousa; Belitardo, Emilia M. M. A.; Rocha, Danilo J. P. G.; Almeida, João P. P.; Pacheco, Luis G. C.; Aguiar, Eric R. G. R.; Campos, Gubio Soares; Sardi, Silvia Inês; Carvalho, Rejane Hughes; Jesus, Amélia Ribeiro de; Rezende, Karla Freire; Almeida, Roque Pacheco de

Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers

Detalhes bibliográficos
Autor(a) principal:	Santos, Letícia Adrielle dos
Data de Publicação:	2021
Outros Autores:	Góis Filho, Pedro Germano de, Silva, Ana Maria Fantini, Santos, João Victor Gomes, Santos, Douglas Siqueira, Aquino, Marília Marques, Jesus, Rafaela Mota de, Almeida, Maria Luiza Dória, Silva, João Santana da, Altmann, Daniel M., Boyton, Rosemary J., Santos, Cliomar Alves dos, Santos, Camilla Natália Oliveira, Alves, Juliana Cardoso, Santos, Ianaline Lima, Magalhães, Lucas Sousa, Belitardo, Emilia M. M. A., Rocha, Danilo J. P. G., Almeida, João P. P., Pacheco, Luis G. C., Aguiar, Eric R. G. R., Campos, Gubio Soares, Sardi, Silvia Inês, Carvalho, Rejane Hughes, Jesus, Amélia Ribeiro de, Rezende, Karla Freire, Almeida, Roque Pacheco de
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/46266
Resumo:	Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

Metadados do item

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spelling	Santos, Letícia Adrielle dosGóis Filho, Pedro Germano deSilva, Ana Maria FantiniSantos, João Victor GomesSantos, Douglas SiqueiraAquino, Marília MarquesJesus, Rafaela Mota deAlmeida, Maria Luiza DóriaSilva, João Santana daAltmann, Daniel M.Boyton, Rosemary J.Santos, Cliomar Alves dosSantos, Camilla Natália OliveiraAlves, Juliana CardosoSantos, Ianaline LimaMagalhães, Lucas SousaBelitardo, Emilia M. M. A.Rocha, Danilo J. P. G.Almeida, João P. P.Pacheco, Luis G. C.Aguiar, Eric R. G. R.Campos, Gubio SoaresSardi, Silvia InêsCarvalho, Rejane HughesJesus, Amélia Ribeiro deRezende, Karla FreireAlmeida, Roque Pacheco de2021-03-05T01:49:04Z2021-03-05T01:49:04Z2021SANTOS, Letícia Adrielle dos et al. Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers. Journal of Infection, p. 1-8, Feb. 2021.0163-4453https://www.arca.fiocruz.br/handle/icict/4626610.1016/j.jinf.2021.01.020Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.Federal University of Sergipe. Immunology Investigative Institute (III). Department of Medicine. INCT, CNPq. Aracaju, SE, Brazil.Federal University of Sergipe. Immunology Investigative Institute (III). Department of Medicine. INCT, CNPq. Aracaju, SE, Brazil.Federal University of Sergipe. Immunology Investigative Institute (III). Department of Medicine. INCT, CNPq. Aracaju, SE, Brazil.Federal University of Sergipe. Immunology Investigative Institute (III). Department of Medicine. INCT, CNPq. Aracaju, SE, Brazil.Federal University of Sergipe. Immunology Investigative Institute (III). Department of Medicine. INCT, CNPq. Aracaju, SE, Brazil.Federal University of Sergipe. Immunology Investigative Institute (III). Department of Medicine. INCT, CNPq. Aracaju, SE, Brazil.Institute of Health Promotion and Assistance for Employees of the State of Sergipe. Division of Pulmonology. Aracaju, SE, Brazil.Federal University of Sergipe. Immunology Investigative Institute (III). Department of Medicine. INCT, CNPq. Aracaju, SE, Brazil.Oswaldo Cruz Foundation. Bi-Institutional Translational Medicine Project. Ribeirão Preto Medical School. Department of Biochemistry and Immunology. Ribeirão Preto, SP, Brazil.Hammersmith Hospital. Imperial College. Faculty of Medicine. Department of Immunology and Inflammation. London, United Kingdom.Hammersmith Hospital. Imperial College. Faculty of Medicine. Department of Immunology and Inflammation. London, United Kingdom.State Secretary for Health. Central Laboratory of Public Health. Health Foundation Parreiras Horta. Aracaju, SE, Brazil.Federal University of Sergipe. University Hospital/EBSERH. Division of Immunology and Molecular Biology Laboratory. Aracaju, SE, Brazil.Federal University of Sergipe. University Hospital/EBSERH. Division of Immunology and Molecular Biology Laboratory. Aracaju, SE, BrazilFederal University of Sergipe. University Hospital/EBSERH. Division of Immunology and Molecular Biology Laboratory. Aracaju, SE, BrazilFederal University of Sergipe. University Hospital/EBSERH. Division of Immunology and Molecular Biology Laboratory. Aracaju, SE, BrazilFederal University of Bahia. Institute of Health Sciences. Salvador, BA, Brazil.Federal University of Bahia. Institute of Health Sciences. Salvador, BA, Brazil.Federal University of Minas Gerais. Institute of Biological Sciences. Belo Horizonte, MG, Brazil.Federal University of Bahia. Institute of Health Sciences. Salvador, BA, Brazil.State University of Santa Cruz. Center of Biotechnology and Genetics. Department of Biological Sciences. Ilhéus, bA, Brazil.Federal University of Bahia. Virology Laboratory, Institute of Health Sciences. Salvador, BA, Brazil.Federal University of Bahia. Institute of Health Sciences. Virology Laboratory. Salvador, BA, Brazil.Federal University of Bahia. Institute of Health Sciences. Virology Laboratory. Salvador, BA, Brazil.Federal University of Sergipe. Immunology Investigative Institute (III). Department of Medicine. INCT, CNPq. Aracaju, SE, Brazil / Federal University of Sergipe. University Hospital/EBSERH. Division of Immunology and Molecular Biology Laboratory. Aracaju, SE, Brazil.Federal University of Sergipe. Immunology Investigative Institute (III). Department of Medicine. INCT, CNPq. Aracaju, SE, Brazil.Federal University of Sergipe. Immunology Investigative Institute (III). Department of Medicine. INCT, CNPq. Aracaju, SE, Brazil / Federal University of Sergipe. University Hospital/EBSERH. Division of Immunology and Molecular Biology Laboratory. Aracaju, SE, Brazil.Background: There is growing concern about individuals reported to suffer repeat COVID-19 disease episodes, these in a small number of cases characterised as de novo infections with distinct sequences, indicative of insufficient protective immunity even in the short term. Methods: Observational case series and case-control studies reporting 33 cases of recurrent, symptomatic, qRTPCR positive COVID-19. Recurrent disease was defined as symptomatic recurrence after symptom-free clinical recovery, with release from isolation >14 days from the beginning of symptoms confirmed by qRT-PCR. The case control study-design compared this group of patients with a control group of 62 patients randomly selected from the same COVID-19 database. Results: Of 33 recurrent COVID-19 patients, 26 were female and 30 were HCW. Mean time to recurrence was 50.5 days which was associated with being a HCW (OR 36.4 (p <0.0001)), and blood type A (OR 4.8 (p = 0.002)). SARS-CoV-2 antibodies were signifcantly lower in recurrent patients after initial COVID-19 (2.4 ±0.610; p<0.0001) and after recurrence (6.4 ±11.34; p = 0.007). Virus genome sequencing identified reinfection by a different isolate in one patient. Conclusions: This is the first detailed case series showing COVID-19 recurrence with qRT-PCR positivity. For one individual detection of phylogenetically distinct genomic sequences in the first and second episodes confirmed bona fide renfection, but in most cases the data do not formally distinguish between reinfection and re-emergence of a chronic infection reservoir. These episodes were significantly associated with reduced Ab response during initial disease and argue the need for ongoing vigilance without an assumption of protection after a first episode.engElsevierRecurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCOVID-19RecurrenceReinfectionSARS-CoV-2Antibodiesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv	Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers
title	Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers
spellingShingle	Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers Santos, Letícia Adrielle dos COVID-19 Recurrence Reinfection SARS-CoV-2 Antibodies
title_short	Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers
title_full	Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers
title_fullStr	Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers
title_full_unstemmed	Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers
title_sort	Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers
author	Santos, Letícia Adrielle dos
author_facet	Santos, Letícia Adrielle dos Góis Filho, Pedro Germano de Silva, Ana Maria Fantini Santos, João Victor Gomes Santos, Douglas Siqueira Aquino, Marília Marques Jesus, Rafaela Mota de Almeida, Maria Luiza Dória Silva, João Santana da Altmann, Daniel M. Boyton, Rosemary J. Santos, Cliomar Alves dos Santos, Camilla Natália Oliveira Alves, Juliana Cardoso Santos, Ianaline Lima Magalhães, Lucas Sousa Belitardo, Emilia M. M. A. Rocha, Danilo J. P. G. Almeida, João P. P. Pacheco, Luis G. C. Aguiar, Eric R. G. R. Campos, Gubio Soares Sardi, Silvia Inês Carvalho, Rejane Hughes Jesus, Amélia Ribeiro de Rezende, Karla Freire Almeida, Roque Pacheco de
author_role	author
author2	Góis Filho, Pedro Germano de Silva, Ana Maria Fantini Santos, João Victor Gomes Santos, Douglas Siqueira Aquino, Marília Marques Jesus, Rafaela Mota de Almeida, Maria Luiza Dória Silva, João Santana da Altmann, Daniel M. Boyton, Rosemary J. Santos, Cliomar Alves dos Santos, Camilla Natália Oliveira Alves, Juliana Cardoso Santos, Ianaline Lima Magalhães, Lucas Sousa Belitardo, Emilia M. M. A. Rocha, Danilo J. P. G. Almeida, João P. P. Pacheco, Luis G. C. Aguiar, Eric R. G. R. Campos, Gubio Soares Sardi, Silvia Inês Carvalho, Rejane Hughes Jesus, Amélia Ribeiro de Rezende, Karla Freire Almeida, Roque Pacheco de
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Santos, Letícia Adrielle dos Góis Filho, Pedro Germano de Silva, Ana Maria Fantini Santos, João Victor Gomes Santos, Douglas Siqueira Aquino, Marília Marques Jesus, Rafaela Mota de Almeida, Maria Luiza Dória Silva, João Santana da Altmann, Daniel M. Boyton, Rosemary J. Santos, Cliomar Alves dos Santos, Camilla Natália Oliveira Alves, Juliana Cardoso Santos, Ianaline Lima Magalhães, Lucas Sousa Belitardo, Emilia M. M. A. Rocha, Danilo J. P. G. Almeida, João P. P. Pacheco, Luis G. C. Aguiar, Eric R. G. R. Campos, Gubio Soares Sardi, Silvia Inês Carvalho, Rejane Hughes Jesus, Amélia Ribeiro de Rezende, Karla Freire Almeida, Roque Pacheco de
dc.subject.en.pt_BR.fl_str_mv	COVID-19 Recurrence Reinfection SARS-CoV-2 Antibodies
topic	COVID-19 Recurrence Reinfection SARS-CoV-2 Antibodies
description	Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
publishDate	2021
dc.date.accessioned.fl_str_mv	2021-03-05T01:49:04Z
dc.date.available.fl_str_mv	2021-03-05T01:49:04Z
dc.date.issued.fl_str_mv	2021
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	SANTOS, Letícia Adrielle dos et al. Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers. Journal of Infection, p. 1-8, Feb. 2021.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/46266
dc.identifier.issn.pt_BR.fl_str_mv	0163-4453
dc.identifier.doi.none.fl_str_mv	10.1016/j.jinf.2021.01.020
identifier_str_mv	SANTOS, Letícia Adrielle dos et al. Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers. Journal of Infection, p. 1-8, Feb. 2021. 0163-4453 10.1016/j.jinf.2021.01.020
url	https://www.arca.fiocruz.br/handle/icict/46266
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers

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