Comparison of whole-body PET/CT, dedicated high-resolution head and neck PET/CT, and contrast-enhanced CT in preoperative staging of clinically M0 squamous cell carcinoma of the head and neck.

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Rosana S.
Data de Publicação: 2009
Outros Autores: Bozza, Fernando A., Christian, Paul E., Hoffman, John M., Christensen, Carl R., Butterfield, Regan I., Wiggins, Richard H., Heilbrun, Marta, Hunt, Jason P., Bentz, Brandon G., Hitchock, Ying J., Morton, Kathryn A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/38909
Resumo: Fernando A. Bozza. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Rodrigues, Rosana S.Bozza, Fernando A.Christian, Paul E.Hoffman, John M.Christensen, Carl R.Butterfield, Regan I.Wiggins, Richard H.Heilbrun, MartaHunt, Jason P.Bentz, Brandon G.Hitchock, Ying J.Morton, Kathryn A.2019-12-30T15:21:33Z2019-12-30T15:21:33Z2009RODRIGUES, Rosana S. et al. Comparison of whole-body PET/CT, dedicated high-resolution head and neck PET/CT, and contrast-enhanced CT in preoperative staging of clinically M0 squamous cell carcinoma of the head and neck. Journal of Nuclear Medicine, v. 50, n. 8, p. 1205-1213, Aug. 2009.0161-5505https://www.arca.fiocruz.br/handle/icict/3890910.2967/jnumed.109.0620752159-662XFernando A. Bozza. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2020-06-30National Institute of Science and Technology in Structural Biology and Bioimaging. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Department of Radiology. Rio de Janeiro, RJ, Brazil.National Institute of Science and Technology in Structural Biology and Bioimaging. Rio de Janeiro, Brazil / Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.University of Utah. Huntsman Cancer Institute. Salt Lake City, UT, USA.University of Utah. Department of Radiology. Salt Lake City, UT, USA.University of Utah. Huntsman Cancer Institute. Salt Lake City, UT, USA.University of Utah. Department of Radiology. Salt Lake City, UT, USA.University of Utah. Department of Radiology. Salt Lake City, UT, USA.University of Utah. Department of Radiology. Salt Lake City, UT, USA.University of Utah. Department of Surgery Division of Otolaryngology–Head and Neck Surgery. Salt Lake City, UT, USA.University of Utah. Department of Surgery Division of Otolaryngology–Head and Neck Surgery. Salt Lake City, UT, USA.University of Utah. Department of Radiation Oncology. Salt Lake City, UT, USA.University of Utah. Department of Radiology. Salt Lake City, UT, USA.The purpose of this study was to compare optimized whole-body (WB) and dedicated high-resolution contrast-enhanced PET/CT protocols and contrast enhanced CT in the preoperative staging of primary squamous cell carcinoma of the head and neck. Methods: A total of 44 patients with clinically M0 squamous cell carcinoma of the head and neck underwent primary tumor resection and neck dissection within 6 wk of diagnostic imaging. Imaging consisted of a standard WB PET/CT protocol without intravenous contrast enhancement, followed by a high-resolution dedicated head and neck (HN) PET/CT protocol, which included diagnostic-quality contrast-enhanced CT (CECT). Imaging results were compared with histopathology. A 5-point scale was used to designate primary tumor localization and the presence of lymph node metastasis on a per-patient and per-level basis. For cervical nodes, receiver-operating-characteristic curves were generated to determine the differences in performance between the WB and HN PET/CT protocols and CECT. Sensitivity, specificity, positive and negative predictive values, and accuracy were calculated for primary tumor and cervical nodes. Results: No statistical difference was observed between WB and HN PET/CT protocols, both of which significantly outperformed CECT, in the evaluation of the primary tumor. The performance of the HN PET/CT protocol was superior to that of the WB PET/CT in the detection of cervical node metastases, achieving statistical significance on a per-level basis and approaching significance on a per-patient basis, with the greatest advantage in the detection of small positive lymph nodes (,15 mm). No significant difference was observed between the WB PET/CT protocol and CECT in nodal staging, either on a per-patient or on a per-level basis. Conclusion: The primary advantage of the dedicated HN PET/CT protocol over the WB protocol or CECT in the staging of head and neck cancer is in the detection of small lymph node metastases.engSociety of Nuclear MedicineComparison of whole-body PET/CT, dedicated high-resolution head and neck PET/CT, and contrast-enhanced CT in preoperative staging of clinically M0 squamous cell carcinoma of the head and neck.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePositron emission tomographyComputed tomographyHead and neck cancerSquamous cell carcinomaTumor staginginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/38909/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Rodrigues_Rosana_etal_INI_2009.pdfve_Rodrigues_Rosana_etal_INI_2009.pdfapplication/pdf1341008https://www.arca.fiocruz.br/bitstream/icict/38909/2/ve_Rodrigues_Rosana_etal_INI_2009.pdf8b389f4025c93854bd9ad21ceeed8817MD52TEXTve_Rodrigues_Rosana_etal_INI_2009.pdf.txtve_Rodrigues_Rosana_etal_INI_2009.pdf.txtExtracted texttext/plain42766https://www.arca.fiocruz.br/bitstream/icict/38909/3/ve_Rodrigues_Rosana_etal_INI_2009.pdf.txtac19773a64df92e52ae989c153465266MD53icict/389092021-03-24 16:32:33.792oai:www.arca.fiocruz.br:icict/38909Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Comparison of whole-body PET/CT, dedicated high-resolution head and neck PET/CT, and contrast-enhanced CT in preoperative staging of clinically M0 squamous cell carcinoma of the head and neck.
title Comparison of whole-body PET/CT, dedicated high-resolution head and neck PET/CT, and contrast-enhanced CT in preoperative staging of clinically M0 squamous cell carcinoma of the head and neck.
spellingShingle Comparison of whole-body PET/CT, dedicated high-resolution head and neck PET/CT, and contrast-enhanced CT in preoperative staging of clinically M0 squamous cell carcinoma of the head and neck.
Rodrigues, Rosana S.
Positron emission tomography
Computed tomography
Head and neck cancer
Squamous cell carcinoma
Tumor staging
title_short Comparison of whole-body PET/CT, dedicated high-resolution head and neck PET/CT, and contrast-enhanced CT in preoperative staging of clinically M0 squamous cell carcinoma of the head and neck.
title_full Comparison of whole-body PET/CT, dedicated high-resolution head and neck PET/CT, and contrast-enhanced CT in preoperative staging of clinically M0 squamous cell carcinoma of the head and neck.
title_fullStr Comparison of whole-body PET/CT, dedicated high-resolution head and neck PET/CT, and contrast-enhanced CT in preoperative staging of clinically M0 squamous cell carcinoma of the head and neck.
title_full_unstemmed Comparison of whole-body PET/CT, dedicated high-resolution head and neck PET/CT, and contrast-enhanced CT in preoperative staging of clinically M0 squamous cell carcinoma of the head and neck.
title_sort Comparison of whole-body PET/CT, dedicated high-resolution head and neck PET/CT, and contrast-enhanced CT in preoperative staging of clinically M0 squamous cell carcinoma of the head and neck.
author Rodrigues, Rosana S.
author_facet Rodrigues, Rosana S.
Bozza, Fernando A.
Christian, Paul E.
Hoffman, John M.
Christensen, Carl R.
Butterfield, Regan I.
Wiggins, Richard H.
Heilbrun, Marta
Hunt, Jason P.
Bentz, Brandon G.
Hitchock, Ying J.
Morton, Kathryn A.
author_role author
author2 Bozza, Fernando A.
Christian, Paul E.
Hoffman, John M.
Christensen, Carl R.
Butterfield, Regan I.
Wiggins, Richard H.
Heilbrun, Marta
Hunt, Jason P.
Bentz, Brandon G.
Hitchock, Ying J.
Morton, Kathryn A.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues, Rosana S.
Bozza, Fernando A.
Christian, Paul E.
Hoffman, John M.
Christensen, Carl R.
Butterfield, Regan I.
Wiggins, Richard H.
Heilbrun, Marta
Hunt, Jason P.
Bentz, Brandon G.
Hitchock, Ying J.
Morton, Kathryn A.
dc.subject.en.pt_BR.fl_str_mv Positron emission tomography
Computed tomography
Head and neck cancer
Squamous cell carcinoma
Tumor staging
topic Positron emission tomography
Computed tomography
Head and neck cancer
Squamous cell carcinoma
Tumor staging
description Fernando A. Bozza. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2019-12-30T15:21:33Z
dc.date.available.fl_str_mv 2019-12-30T15:21:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv RODRIGUES, Rosana S. et al. Comparison of whole-body PET/CT, dedicated high-resolution head and neck PET/CT, and contrast-enhanced CT in preoperative staging of clinically M0 squamous cell carcinoma of the head and neck. Journal of Nuclear Medicine, v. 50, n. 8, p. 1205-1213, Aug. 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/38909
dc.identifier.issn.pt_BR.fl_str_mv 0161-5505
dc.identifier.doi.none.fl_str_mv 10.2967/jnumed.109.062075
dc.identifier.eissn.none.fl_str_mv 2159-662X
identifier_str_mv RODRIGUES, Rosana S. et al. Comparison of whole-body PET/CT, dedicated high-resolution head and neck PET/CT, and contrast-enhanced CT in preoperative staging of clinically M0 squamous cell carcinoma of the head and neck. Journal of Nuclear Medicine, v. 50, n. 8, p. 1205-1213, Aug. 2009.
0161-5505
10.2967/jnumed.109.062075
2159-662X
url https://www.arca.fiocruz.br/handle/icict/38909
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dc.publisher.none.fl_str_mv Society of Nuclear Medicine
publisher.none.fl_str_mv Society of Nuclear Medicine
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