Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18801 |
Resumo: | Inclui apresentação em powerpoint com o título "Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico". 12 p. Autores: Davide F. Robbiani, Leonia Bozzacco, Jennifer R. Keeffe, Ricardo Khouri, Priscilla C. Olsen, Anna Gazumyan, Dennis Schaefer-Babajew, Santiago Avila-Rios, Lilian Nogueira, Roshni Patel, Stephanie A. Azzopardi, Lion F.K. Uhl, Mohsan Saeed, Edgar E. Sevilla-Reyes, Marianna Agudelo, Kai-Hui Yao, Jovana Golijanin, Harry B. Gristick, Yu E. Lee, Arlene Hurley, Marina Caskey, Joy Pai, Thiago Oliveira, Elsio A. Wunder, Gielson Sacramento, Nivison Nery, Cibele Orge, Federico Costa, Mitermayer G. Reis, Neena M. Thomas, Thomas Eisenreich, Daniel M. Weinberger, Antonio R.P. de Almeida, Anthony P. West, Charles M. Rice, Pamela J. Bjorkman, Gustavo Reyes-Teran, Albert I. Ko, Margaret R. MacDonald, Michel C. Nussenzweig. |
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Robbiani, Davide FCunha, Antonio Ricardo KhouriWunder Junior, Elsio AugustoSacramento, GielsonNery Junior, Nivison Ruy RochaOrge, CibeleCosta, FedericoReis, Mitermayer Galvão dosKo, Albert IcksangMúltipla - ver em Notas2017-05-09T17:34:06Z2017-05-09T17:34:06Z2017ROBBIANI, D. F. et al. Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico. Cell, v. 169, p. 597–609, 2017.0092-8674https://www.arca.fiocruz.br/handle/icict/1880110.1016/j.cell.2017.04.024Inclui apresentação em powerpoint com o título "Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico". 12 p. Autores: Davide F. Robbiani, Leonia Bozzacco, Jennifer R. Keeffe, Ricardo Khouri, Priscilla C. Olsen, Anna Gazumyan, Dennis Schaefer-Babajew, Santiago Avila-Rios, Lilian Nogueira, Roshni Patel, Stephanie A. Azzopardi, Lion F.K. Uhl, Mohsan Saeed, Edgar E. Sevilla-Reyes, Marianna Agudelo, Kai-Hui Yao, Jovana Golijanin, Harry B. Gristick, Yu E. Lee, Arlene Hurley, Marina Caskey, Joy Pai, Thiago Oliveira, Elsio A. Wunder, Gielson Sacramento, Nivison Nery, Cibele Orge, Federico Costa, Mitermayer G. Reis, Neena M. Thomas, Thomas Eisenreich, Daniel M. Weinberger, Antonio R.P. de Almeida, Anthony P. West, Charles M. Rice, Pamela J. Bjorkman, Gustavo Reyes-Teran, Albert I. Ko, Margaret R. MacDonald, Michel C. Nussenzweig.2018-05-04The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USAFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilAntibodies to Zika virus (ZIKV) can be protective. To examine the antibody response in individuals who develop high titers of anti-ZIKV antibodies, we screened cohorts in Brazil and Mexico for ZIKV envelope domain III (ZEDIII) binding and neutralization. We find that serologic reactivity to dengue 1 virus (DENV1) EDIII before ZIKV exposure is associated with increased ZIKV neutralizing titers after exposure. Antibody cloning shows that donors with high ZIKV neutralizing antibody titers have expanded clones of memory B cells that express the same immunoglobulin VH3-23/VK1-5 genes. These recurring antibodies cross-react with DENV1, but not other flaviviruses, neutralize both DENV1 and ZIKV, and protect mice against ZIKV challenge. Structural analyses reveal the mechanism of recognition of the ZEDIII lateral ridge by VH3-23/VK1-5 antibodies. Serologic testing shows that antibodies to this region correlate with serum neutralizing activity to ZIKV. Thus, high neutralizing responses to ZIKV are associated with pre-existing reactivity to DENV1 in humans.engElsevierZika vírusAnticorposDengue vírusEstruturaFlavivirusZika virusAntibodiesDengue virusFlavivirusStructureVaccineZika vírusAnticorposDengue vírusFlavivirusRecurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexicoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18801/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRobbiani DF Recurrent Potent Human Neutralizing Antibodies to Zika Virus....pdfRobbiani DF Recurrent Potent Human Neutralizing Antibodies to Zika Virus....pdfArtigo 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| dc.title.pt_BR.fl_str_mv |
Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico |
| title |
Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico |
| spellingShingle |
Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico Robbiani, Davide F Zika vírus Anticorpos Dengue vírus Estrutura Flavivirus Zika virus Antibodies Dengue virus Flavivirus Structure Vaccine Zika vírus Anticorpos Dengue vírus Flavivirus |
| title_short |
Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico |
| title_full |
Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico |
| title_fullStr |
Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico |
| title_full_unstemmed |
Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico |
| title_sort |
Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico |
| author |
Robbiani, Davide F |
| author_facet |
Robbiani, Davide F Cunha, Antonio Ricardo Khouri Wunder Junior, Elsio Augusto Sacramento, Gielson Nery Junior, Nivison Ruy Rocha Orge, Cibele Costa, Federico Reis, Mitermayer Galvão dos Ko, Albert Icksang Múltipla - ver em Notas |
| author_role |
author |
| author2 |
Cunha, Antonio Ricardo Khouri Wunder Junior, Elsio Augusto Sacramento, Gielson Nery Junior, Nivison Ruy Rocha Orge, Cibele Costa, Federico Reis, Mitermayer Galvão dos Ko, Albert Icksang Múltipla - ver em Notas |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Robbiani, Davide F Cunha, Antonio Ricardo Khouri Wunder Junior, Elsio Augusto Sacramento, Gielson Nery Junior, Nivison Ruy Rocha Orge, Cibele Costa, Federico Reis, Mitermayer Galvão dos Ko, Albert Icksang Múltipla - ver em Notas |
| dc.subject.other.pt_BR.fl_str_mv |
Zika vírus Anticorpos Dengue vírus Estrutura |
| topic |
Zika vírus Anticorpos Dengue vírus Estrutura Flavivirus Zika virus Antibodies Dengue virus Flavivirus Structure Vaccine Zika vírus Anticorpos Dengue vírus Flavivirus |
| dc.subject.other.none.fl_str_mv |
Flavivirus |
| dc.subject.en.pt_BR.fl_str_mv |
Zika virus Antibodies Dengue virus Flavivirus Structure Vaccine |
| dc.subject.decs.pt_BR.fl_str_mv |
Zika vírus Anticorpos Dengue vírus Flavivirus |
| description |
Inclui apresentação em powerpoint com o título "Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico". 12 p. Autores: Davide F. Robbiani, Leonia Bozzacco, Jennifer R. Keeffe, Ricardo Khouri, Priscilla C. Olsen, Anna Gazumyan, Dennis Schaefer-Babajew, Santiago Avila-Rios, Lilian Nogueira, Roshni Patel, Stephanie A. Azzopardi, Lion F.K. Uhl, Mohsan Saeed, Edgar E. Sevilla-Reyes, Marianna Agudelo, Kai-Hui Yao, Jovana Golijanin, Harry B. Gristick, Yu E. Lee, Arlene Hurley, Marina Caskey, Joy Pai, Thiago Oliveira, Elsio A. Wunder, Gielson Sacramento, Nivison Nery, Cibele Orge, Federico Costa, Mitermayer G. Reis, Neena M. Thomas, Thomas Eisenreich, Daniel M. Weinberger, Antonio R.P. de Almeida, Anthony P. West, Charles M. Rice, Pamela J. Bjorkman, Gustavo Reyes-Teran, Albert I. Ko, Margaret R. MacDonald, Michel C. Nussenzweig. |
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2017 |
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2017-05-09T17:34:06Z |
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2017-05-09T17:34:06Z |
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2017 |
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info:eu-repo/semantics/publishedVersion |
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ROBBIANI, D. F. et al. Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico. Cell, v. 169, p. 597–609, 2017. |
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https://www.arca.fiocruz.br/handle/icict/18801 |
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0092-8674 |
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10.1016/j.cell.2017.04.024 |
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ROBBIANI, D. F. et al. Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico. Cell, v. 169, p. 597–609, 2017. 0092-8674 10.1016/j.cell.2017.04.024 |
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Elsevier |
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Elsevier |
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