Previous dengue or Zika virus exposure can drive to infection enhancement or neutralisation of other flaviviruses
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/35713 |
Resumo: | Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (Facepe) (grant BFP-0117-2.11/13), for granting RASO a visiting research fellowship and EFO-F (grant APQ 1380-5.05/15) and CNPq (DCR-0003-5.05/16), and to Louisa F. Ludwig-Begall |
| id |
CRUZ_dc3b6e7f69ebcc331448ab66c83ed792 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/35713 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Oliveira, Renato A. S.Oliveira-Filho, Edmilson F. deBrito, Carlos A. A.Marques, Ernesto T. A.Tenório, Marli C.Gil, Laura H. G. V.2019-09-20T13:15:53Z2019-09-20T13:15:53Z2019OLIVEIRA, Renato. A. S. et al. Previous Dengue or Zika Virus Exposure Can drive to Infection Enhancement or Neutralisation of Other Flaviviruses. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-7, 2019.1678-8060https://www.arca.fiocruz.br/handle/icict/3571310.1590/0074-02760190098Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (Facepe) (grant BFP-0117-2.11/13), for granting RASO a visiting research fellowship and EFO-F (grant APQ 1380-5.05/15) and CNPq (DCR-0003-5.05/16), and to Louisa F. Ludwig-BegallUniversidade Federal da Paraíba. Departamento de Fisiologia e Patologia. João Pessoa, PB, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil / Charité-Universitätsmedizin. Berlin. Berlin, Germany.Universidade Federal da Paraíba. Hospital Universitário Lauro Wanderley. Serviço de Doenças Infecciosas e Parasitárias. João Pessoa, PB, Brasil / Universidade Federal da Paraíba. Escola Técnica de Saúde. Grupo de Estudos e Pesquisas em Imunologia Humana. João Pessoa, PB, Brasil.Universidade Federal de Pernambuco. Departamento de Medicina Clínica. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil / University of Pittsburgh. Center for Vaccine Research. Department of Infectious Diseases and Microbiology. Pittsburgh, PA, USA.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil.BACKGROUND Dengue virus (DENV) has circulated in Brazil for over 30 years. During this time, one serotype has cyclically replaced the other, until recently, when all four distinct serotypes began to circulate together. Persistent circulation of DENV for long time periods makes sequential infections throughout a person’s life possible. After primary DENV infection, life-long immunity is developed for the infecting serotype. Since DENV and Zika virus (ZIKV) are antigenically similar, the possibility of cross-reactions has attracted attention and has been demonstrated in vitro. OBJECTIVE The aim of this study was to investigate whether immune-sera from DENV and ZIKV infected patients would crossreact in vitro with other Flaviviridae family members. METHODS Cross-reaction of the studied samples with yellow fever virus (YFV), West Nile virus (WNV), Rocio virus (ROCV), Saint Louis virus (SLEV) and Ilheus virus (ILHV) has been investigated by plaque reduction neutralisation test (PRNT) and the antibody-dependent enhancement (ADE) by flow-cytometry. FINDINGS Antibodies against ZIKV and DENV virus cross-reacted with other flaviviruses either neutralising or enhancing the infection. Thus, viral entrance into FcRFcɣRII-expressing cells were influenced by the cross-reactive antibodies. ZIKV or DENV immune sera enhanced cellular infection by WNV, ILHV, ROCV and SLEV. Finally, DENV immune sera presented higher neutralising activity for YFV and SLEV. While ZIKV immune sera neutralised WNV, ILHV and ROCV with high frequencies of positivity. MAIN CONCLUSIONS The co-circulation of those viruses in the same area represents a risk for the development of severe infections if they spread throughout the country. Successive flavivirus infections may have an impact on disease pathogenesis, as well as on the development of safe vaccine strategies.engPrevious dengue or Zika virus exposure can drive to infection enhancement or neutralisation of other flavivirusesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleADEFlavivirusDengueZikaAnticorpos Neutralizadores / imunologiaAnticorpos virais / imunologiaReações cruzadas / imunologiaVírus da dengue / imunologiaFlavivírus / classificaçãoFlavivírus / imunologiaCitometria de fluxoHumanosTestes de neutralizaçãoVírus Zika / imunologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83094https://www.arca.fiocruz.br/bitstream/icict/35713/1/license.txtee3692f7b0b97d5638099ab94397d05fMD51ORIGINALPrevious dengue or Zika virus exposure can drive to infection.pdfPrevious dengue or Zika virus exposure can drive to infection.pdfapplication/pdf720255https://www.arca.fiocruz.br/bitstream/icict/35713/2/Previous%20dengue%20or%20Zika%20virus%20exposure%20can%20drive%20to%20infection.pdfb461dd8eab962758ca4f956a764907abMD52TEXTPrevious dengue or Zika virus exposure can drive to infection.pdf.txtPrevious dengue or Zika virus exposure can drive to infection.pdf.txtExtracted texttext/plain28291https://www.arca.fiocruz.br/bitstream/icict/35713/3/Previous%20dengue%20or%20Zika%20virus%20exposure%20can%20drive%20to%20infection.pdf.txt552762c589c5751b5ca801454e517abdMD53icict/357132019-09-22 12:19:37.894oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-09-22T15:19:37Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Previous dengue or Zika virus exposure can drive to infection enhancement or neutralisation of other flaviviruses |
| title |
Previous dengue or Zika virus exposure can drive to infection enhancement or neutralisation of other flaviviruses |
| spellingShingle |
Previous dengue or Zika virus exposure can drive to infection enhancement or neutralisation of other flaviviruses Oliveira, Renato A. S. ADE Flavivirus Dengue Zika Anticorpos Neutralizadores / imunologia Anticorpos virais / imunologia Reações cruzadas / imunologia Vírus da dengue / imunologia Flavivírus / classificação Flavivírus / imunologia Citometria de fluxo Humanos Testes de neutralização Vírus Zika / imunologia |
| title_short |
Previous dengue or Zika virus exposure can drive to infection enhancement or neutralisation of other flaviviruses |
| title_full |
Previous dengue or Zika virus exposure can drive to infection enhancement or neutralisation of other flaviviruses |
| title_fullStr |
Previous dengue or Zika virus exposure can drive to infection enhancement or neutralisation of other flaviviruses |
| title_full_unstemmed |
Previous dengue or Zika virus exposure can drive to infection enhancement or neutralisation of other flaviviruses |
| title_sort |
Previous dengue or Zika virus exposure can drive to infection enhancement or neutralisation of other flaviviruses |
| author |
Oliveira, Renato A. S. |
| author_facet |
Oliveira, Renato A. S. Oliveira-Filho, Edmilson F. de Brito, Carlos A. A. Marques, Ernesto T. A. Tenório, Marli C. Gil, Laura H. G. V. |
| author_role |
author |
| author2 |
Oliveira-Filho, Edmilson F. de Brito, Carlos A. A. Marques, Ernesto T. A. Tenório, Marli C. Gil, Laura H. G. V. |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Renato A. S. Oliveira-Filho, Edmilson F. de Brito, Carlos A. A. Marques, Ernesto T. A. Tenório, Marli C. Gil, Laura H. G. V. |
| dc.subject.en.pt_BR.fl_str_mv |
ADE Flavivirus Dengue Zika |
| topic |
ADE Flavivirus Dengue Zika Anticorpos Neutralizadores / imunologia Anticorpos virais / imunologia Reações cruzadas / imunologia Vírus da dengue / imunologia Flavivírus / classificação Flavivírus / imunologia Citometria de fluxo Humanos Testes de neutralização Vírus Zika / imunologia |
| dc.subject.decs.pt_BR.fl_str_mv |
Anticorpos Neutralizadores / imunologia Anticorpos virais / imunologia Reações cruzadas / imunologia Vírus da dengue / imunologia Flavivírus / classificação Flavivírus / imunologia Citometria de fluxo Humanos Testes de neutralização Vírus Zika / imunologia |
| description |
Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (Facepe) (grant BFP-0117-2.11/13), for granting RASO a visiting research fellowship and EFO-F (grant APQ 1380-5.05/15) and CNPq (DCR-0003-5.05/16), and to Louisa F. Ludwig-Begall |
| publishDate |
2019 |
| dc.date.accessioned.fl_str_mv |
2019-09-20T13:15:53Z |
| dc.date.available.fl_str_mv |
2019-09-20T13:15:53Z |
| dc.date.issued.fl_str_mv |
2019 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
OLIVEIRA, Renato. A. S. et al. Previous Dengue or Zika Virus Exposure Can drive to Infection Enhancement or Neutralisation of Other Flaviviruses. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-7, 2019. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/35713 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1678-8060 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/0074-02760190098 |
| identifier_str_mv |
OLIVEIRA, Renato. A. S. et al. Previous Dengue or Zika Virus Exposure Can drive to Infection Enhancement or Neutralisation of Other Flaviviruses. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-7, 2019. 1678-8060 10.1590/0074-02760190098 |
| url |
https://www.arca.fiocruz.br/handle/icict/35713 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/35713/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/35713/2/Previous%20dengue%20or%20Zika%20virus%20exposure%20can%20drive%20to%20infection.pdf https://www.arca.fiocruz.br/bitstream/icict/35713/3/Previous%20dengue%20or%20Zika%20virus%20exposure%20can%20drive%20to%20infection.pdf.txt |
| bitstream.checksum.fl_str_mv |
ee3692f7b0b97d5638099ab94397d05f b461dd8eab962758ca4f956a764907ab 552762c589c5751b5ca801454e517abd |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1798324645936496640 |