Risk of microcephaly after Zika virus infection in Brazil, 2015 to 2016

Detalhes bibliográficos
Autor(a) principal: Jaenisch, Thomas
Data de Publicação: 2017
Outros Autores: Rosenberger, Kerstin Daniela, Brito, Carlos, Brady, Oliver, Brasil, Patrícia, Marques, Ernesto Ta
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/19487
Resumo: Heidelberg University Hospital. Section of Clinical Tropical Medicine. Department of Infectious Diseases. Heidelberg, Germany.
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spelling Jaenisch, ThomasRosenberger, Kerstin DanielaBrito, CarlosBrady, OliverBrasil, PatríciaMarques, Ernesto Ta2017-06-22T13:26:28Z2017-06-22T13:26:28Z2017JAENISCH, Thomas et al. Risk of microcephaly after Zika virus infection in Brazil, 2015 to 2016. Bulletin of the World Health Organization, v. 95, n. 3, p. 191-198, Mar. 2017.1564-0604https://www.arca.fiocruz.br/handle/icict/1948710.2471/BLT.16.178608engRisk of microcephaly after Zika virus infection in Brazil, 2015 to 2016info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHeidelberg University Hospital. Section of Clinical Tropical Medicine. Department of Infectious Diseases. Heidelberg, Germany.Heidelberg University Hospital. Section of Clinical Tropical Medicine. Department of Infectious Diseases. Heidelberg, Germany.Federal University of Pernambuco. Department of Internal Medicine. Recife, PE, Brazil.London School of Hygiene & Tropical Medicine. Department of Infectious Disease Epidemiology. London, England.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil.OBJECTIVE: To estimate the risk of microcephaly in babies born to women infected by the Zika virus during pregnancy in Brazil in an epidemic between 2015 and 2016. METHODS: We obtained data on the number of notified and confirmed microcephaly cases in each Brazilian state between November 2015 and October 2016 from the health ministry. For Pernambuco State, one of the hardest hit, weekly data were available from August 2015 to October 2016 for different definitions of microcephaly. The absolute risk of microcephaly was calculated using the average number of live births reported in each state in the corresponding time period between 2012 and 2014 and assuming two infection rates: 10% and 50%. The relative risk was estimated using the reported background frequency of microcephaly in Brazil of 1.98 per 10 000 live births. FINDINGS: The estimated absolute risk of a notified microcephaly case varied from 0.03 to 17.1% according to geographical area, the definition of microcephaly used and the infection rate. Assuming a 50% infection rate, there was an 18-127 fold higher probability of microcephaly in children born to mothers with infection during pregnancy compared with children born to mothers without infection during pregnancy in Pernambuco State. For a 10% infection rate, the probability was 88-635 folds higher. CONCLUSION: A large variation in the estimated risk of microcephaly was found in Brazil. Research is needed into possible effect modifiers, reliable measures of Zika virus infection and clear endpoints for congenital malformations.MicrocephalyZika Virus infectionZika VirusBrazilMicrocefalia / etiologiaComplicações na Gravidez InfecciosaInfecção pelo vírus Zika / complicaçõesAvaliação de Riscoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19487/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINAL28250532 2017 jae-ris.oa.pdf28250532 2017 jae-ris.oa.pdfapplication/pdf485093https://www.arca.fiocruz.br/bitstream/icict/19487/2/28250532%202017%20jae-ris.oa.pdfa3a0105d13cf4745dacbc9cbdca2dcadMD52TEXT28250532 2017 jae-ris.oa.pdf.txt28250532 2017 jae-ris.oa.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Risk of microcephaly after Zika virus infection in Brazil, 2015 to 2016
title Risk of microcephaly after Zika virus infection in Brazil, 2015 to 2016
spellingShingle Risk of microcephaly after Zika virus infection in Brazil, 2015 to 2016
Jaenisch, Thomas
Microcephaly
Zika Virus infection
Zika Virus
Brazil
Microcefalia / etiologia
Complicações na Gravidez Infecciosa
Infecção pelo vírus Zika / complicações
Avaliação de Risco
title_short Risk of microcephaly after Zika virus infection in Brazil, 2015 to 2016
title_full Risk of microcephaly after Zika virus infection in Brazil, 2015 to 2016
title_fullStr Risk of microcephaly after Zika virus infection in Brazil, 2015 to 2016
title_full_unstemmed Risk of microcephaly after Zika virus infection in Brazil, 2015 to 2016
title_sort Risk of microcephaly after Zika virus infection in Brazil, 2015 to 2016
author Jaenisch, Thomas
author_facet Jaenisch, Thomas
Rosenberger, Kerstin Daniela
Brito, Carlos
Brady, Oliver
Brasil, Patrícia
Marques, Ernesto Ta
author_role author
author2 Rosenberger, Kerstin Daniela
Brito, Carlos
Brady, Oliver
Brasil, Patrícia
Marques, Ernesto Ta
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Jaenisch, Thomas
Rosenberger, Kerstin Daniela
Brito, Carlos
Brady, Oliver
Brasil, Patrícia
Marques, Ernesto Ta
dc.subject.en.pt_BR.fl_str_mv Microcephaly
Zika Virus infection
Zika Virus
Brazil
topic Microcephaly
Zika Virus infection
Zika Virus
Brazil
Microcefalia / etiologia
Complicações na Gravidez Infecciosa
Infecção pelo vírus Zika / complicações
Avaliação de Risco
dc.subject.decs.none.fl_str_mv Microcefalia / etiologia
Complicações na Gravidez Infecciosa
Infecção pelo vírus Zika / complicações
Avaliação de Risco
description Heidelberg University Hospital. Section of Clinical Tropical Medicine. Department of Infectious Diseases. Heidelberg, Germany.
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-06-22T13:26:28Z
dc.date.available.fl_str_mv 2017-06-22T13:26:28Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv JAENISCH, Thomas et al. Risk of microcephaly after Zika virus infection in Brazil, 2015 to 2016. Bulletin of the World Health Organization, v. 95, n. 3, p. 191-198, Mar. 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/19487
dc.identifier.issn.pt_BR.fl_str_mv 1564-0604
dc.identifier.doi.pt_BR.fl_str_mv 10.2471/BLT.16.178608
identifier_str_mv JAENISCH, Thomas et al. Risk of microcephaly after Zika virus infection in Brazil, 2015 to 2016. Bulletin of the World Health Organization, v. 95, n. 3, p. 191-198, Mar. 2017.
1564-0604
10.2471/BLT.16.178608
url https://www.arca.fiocruz.br/handle/icict/19487
dc.language.iso.fl_str_mv eng
language eng
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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