Lower galactosylation levels of the Lipophosphoglycan from Leishmania (Leishmania) major-like strains affect interaction with Phlebotomus papatasi and Lutzomyia longipalpis
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28684 |
Resumo: | Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil |
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Guimarães, Agna CristinaNogueira, Paula MonalisaSilva, Soraia de OliveiraSadlova, JovanaPruzinova, KaterinaHlavacova, JanaMelo, Maria NormaSoares, Rodrigo Pedro Pinto2018-09-12T14:14:08Z2018-09-12T14:14:08Z2018GUIMARAES, Agna Cristina et al. Lower galactosylation levels of the Lipophosphoglycan from Leishmania (Leishmania) major-like strains affect interaction with Phlebotomus papatasi and Lutzomyia longipalpis. Mem. Inst. Oswaldo Cruz, v. 113, n. 5, e170333, 20181678-8060https://www.arca.fiocruz.br/handle/icict/2868410.1590/0074-02760170333engFundação Oswaldo CruzLeishmania majorlipofosfoglicanoInteração parasita-hospedeiroPhlebotomus papatasiLutzomyia longipalpisLeishmania majorlipophosphoglycanhost-parasite interactionPhlebotomus papatasiLutzomyia longipalpisLower galactosylation levels of the Lipophosphoglycan from Leishmania (Leishmania) major-like strains affect interaction with Phlebotomus papatasi and Lutzomyia longipalpisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, BrasilCharles University. Faculty of Science. Department of Parasitology. Prague, Czech RepublicCharles University. Faculty of Science. Department of Parasitology. Prague, Czech RepublicCharles University. Faculty of Science. Department of Parasitology. Prague, Czech RepublicUniversidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrasilBACKGROUND: Leishmania major is an Old World species causing cutaneous leishmaniasis and is transmitted by Phlebotomus papatasi and Phlebotomus duboscqi. In Brazil, two isolates from patients who never left the country were characterised as L. major-like (BH49 and BH121). Using molecular techniques, these isolates were indistinguishable from the L. major reference strain (FV1). OBJECTIVES; We evaluated the lipophosphoglycans (LPGs) of the strains and their behaviour in Old and New World sand fly vectors. METHODS: LPGs were purified, and repeat units were qualitatively evaluated by immunoblotting. Experimental in vivo infection with L. major-like strains was performed in Lutzomyia longipalpis (New World, permissive vector) and Ph. papatasi(Old World, restrictive or specific vector). FINDINGS: The LPGs of both strains were devoid of arabinosylated side chains, whereas the LPG of strain BH49 was more galactosylated than that of strain BH121. All strains with different levels of galactosylation in their LPGs were able to infect both vectors, exhibiting colonisation of the stomodeal valve and metacyclogenesis. The BH121 strain (less galactosylated) exhibited lower infection intensity compared to BH49 and FV1 in both vectors. MAIN CONCLUSIONS: Intraspecific variation in the LPG of L. major-like strains occur, and the different galactosylation levels affected interactions with the invertebrate host.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/28684/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALLower galactosylation levels of the Lipophosphoglycan.pdfLower galactosylation levels of the Lipophosphoglycan.pdfapplication/pdf1259767https://www.arca.fiocruz.br/bitstream/icict/28684/2/Lower%20galactosylation%20levels%20of%20the%20Lipophosphoglycan.pdf302112277d5819bd862fbff018c895f8MD52TEXTLower galactosylation levels of the Lipophosphoglycan.pdf.txtLower galactosylation levels of the Lipophosphoglycan.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Lower galactosylation levels of the Lipophosphoglycan from Leishmania (Leishmania) major-like strains affect interaction with Phlebotomus papatasi and Lutzomyia longipalpis |
title |
Lower galactosylation levels of the Lipophosphoglycan from Leishmania (Leishmania) major-like strains affect interaction with Phlebotomus papatasi and Lutzomyia longipalpis |
spellingShingle |
Lower galactosylation levels of the Lipophosphoglycan from Leishmania (Leishmania) major-like strains affect interaction with Phlebotomus papatasi and Lutzomyia longipalpis Guimarães, Agna Cristina Leishmania major lipofosfoglicano Interação parasita-hospedeiro Phlebotomus papatasi Lutzomyia longipalpis Leishmania major lipophosphoglycan host-parasite interaction Phlebotomus papatasi Lutzomyia longipalpis |
title_short |
Lower galactosylation levels of the Lipophosphoglycan from Leishmania (Leishmania) major-like strains affect interaction with Phlebotomus papatasi and Lutzomyia longipalpis |
title_full |
Lower galactosylation levels of the Lipophosphoglycan from Leishmania (Leishmania) major-like strains affect interaction with Phlebotomus papatasi and Lutzomyia longipalpis |
title_fullStr |
Lower galactosylation levels of the Lipophosphoglycan from Leishmania (Leishmania) major-like strains affect interaction with Phlebotomus papatasi and Lutzomyia longipalpis |
title_full_unstemmed |
Lower galactosylation levels of the Lipophosphoglycan from Leishmania (Leishmania) major-like strains affect interaction with Phlebotomus papatasi and Lutzomyia longipalpis |
title_sort |
Lower galactosylation levels of the Lipophosphoglycan from Leishmania (Leishmania) major-like strains affect interaction with Phlebotomus papatasi and Lutzomyia longipalpis |
author |
Guimarães, Agna Cristina |
author_facet |
Guimarães, Agna Cristina Nogueira, Paula Monalisa Silva, Soraia de Oliveira Sadlova, Jovana Pruzinova, Katerina Hlavacova, Jana Melo, Maria Norma Soares, Rodrigo Pedro Pinto |
author_role |
author |
author2 |
Nogueira, Paula Monalisa Silva, Soraia de Oliveira Sadlova, Jovana Pruzinova, Katerina Hlavacova, Jana Melo, Maria Norma Soares, Rodrigo Pedro Pinto |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Guimarães, Agna Cristina Nogueira, Paula Monalisa Silva, Soraia de Oliveira Sadlova, Jovana Pruzinova, Katerina Hlavacova, Jana Melo, Maria Norma Soares, Rodrigo Pedro Pinto |
dc.subject.other.pt_BR.fl_str_mv |
Leishmania major lipofosfoglicano Interação parasita-hospedeiro Phlebotomus papatasi Lutzomyia longipalpis |
topic |
Leishmania major lipofosfoglicano Interação parasita-hospedeiro Phlebotomus papatasi Lutzomyia longipalpis Leishmania major lipophosphoglycan host-parasite interaction Phlebotomus papatasi Lutzomyia longipalpis |
dc.subject.en.pt_BR.fl_str_mv |
Leishmania major lipophosphoglycan host-parasite interaction Phlebotomus papatasi Lutzomyia longipalpis |
description |
Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-09-12T14:14:08Z |
dc.date.available.fl_str_mv |
2018-09-12T14:14:08Z |
dc.date.issued.fl_str_mv |
2018 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GUIMARAES, Agna Cristina et al. Lower galactosylation levels of the Lipophosphoglycan from Leishmania (Leishmania) major-like strains affect interaction with Phlebotomus papatasi and Lutzomyia longipalpis. Mem. Inst. Oswaldo Cruz, v. 113, n. 5, e170333, 2018 |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/28684 |
dc.identifier.issn.pt_BR.fl_str_mv |
1678-8060 |
dc.identifier.doi.none.fl_str_mv |
10.1590/0074-02760170333 |
identifier_str_mv |
GUIMARAES, Agna Cristina et al. Lower galactosylation levels of the Lipophosphoglycan from Leishmania (Leishmania) major-like strains affect interaction with Phlebotomus papatasi and Lutzomyia longipalpis. Mem. Inst. Oswaldo Cruz, v. 113, n. 5, e170333, 2018 1678-8060 10.1590/0074-02760170333 |
url |
https://www.arca.fiocruz.br/handle/icict/28684 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Fundação Oswaldo Cruz |
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Fundação Oswaldo Cruz |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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