Lipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpis

Detalhes bibliográficos
Autor(a) principal: Nogueira, Paula Monalisa
Data de Publicação: 2017
Outros Autores: Guimarães, Agna Cristina, Assis, Rafael Ramiro de, Sadlova, Jovana, Myskova, Jitka, Pruzinova, Katerina, Hlavackova, Jana, Turco, Salvatore J., Torrecilhas, Ana Claudia Trocoli, Volf, Petr, Soares, Rodrigo Pedro Pinto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25140
Resumo: Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG Brazil/Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil
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spelling Nogueira, Paula MonalisaGuimarães, Agna CristinaAssis, Rafael Ramiro deSadlova, JovanaMyskova, JitkaPruzinova, KaterinaHlavackova, JanaTurco, Salvatore J.Torrecilhas, Ana Claudia TrocoliVolf, PetrSoares, Rodrigo Pedro Pinto2018-03-07T16:36:12Z2018-03-07T16:36:12Z2017NOGUEIRA, Paula Monalisa et al. Lipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpis. Parasit Vectors, v. 10, n. 1, p. 608, 20171756-3305https://www.arca.fiocruz.br/handle/icict/2514010.1186/s13071-017-2568-8engBioMed CentralLeishmania amazonensisLutzomyia longipalpisLutzomyia migoneiPhlebotomus papatasiLeishmania amazonensisLipophosphoglycanLutzomyia longipalpisLutzomyia migoneiPhlebotomus papatasiVector-parasite interactionLipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG Brazil/Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG BrazilCharles University. Faculty of Science. Department of Parasitology. Prague, Czech RepublicCharles University. Faculty of Science. Department of Parasitology. Prague, Czech RepublicCharles University. Faculty of Science. Department of Parasitology. Prague, Czech RepublicCharles University. Faculty of Science. Department of Parasitology. Prague, Czech RepublicUniversity of Kentucky Medical Center. Department of Biochemistry. Lexington, KY USAUniversisade Federal de São Paulo. Departamento de Farmácia. Laboratório de Imunologia Celular e Bioquímica de Fungos e Protozoários. São Paulo, SP BrazilCharles University. Faculty of Science. Department of Parasitology. Prague, Czech RepublicFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG BrazilBackground: Lipophosphoglycan (LPG) is a dominant surface molecule of Leishmania promastigotes. Its species-specific polymorphisms are found mainly in the sugars that branch off the conserved Gal(β1,4)Man(α1)-PO4 backbone of repeat units. Leishmania amazonensis is one of the most important species causing human cutaneous leishmaniasis in the New World. Here, we describe LPG intraspecific polymorphisms in two Le. amazonensis reference strains and their role during the development in three sand fly species. Results: Strains isolated from Lutzomyia flaviscutellata (PH8) and from a human patient (Josefa) displayed structural polymorphism in the LPG repeat units, possessing side chains with 1 and 2 β-glucose or 1 to 3 β-galactose, respectively. Both strains successfully infected permissive vectors Lutzomyia longipalpis and Lutzomyia migonei and could colonize their stomodeal valve and differentiate into metacyclic forms. Despite bearing terminal galactose residues on LPG, Josefa could not sustain infection in the restrictive vector Phlebotomus papatasi. Conclusions: LPG polymorphisms did not affect the ability of Le. amazonensis to develop late-stage infections in permissive vectors. However, the non-establishment of infection in Ph. papatasi by Josefa strain suggested other LPG-independent factors in this restrictive vector.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/25140/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALLipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpis.pdfLipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpis.pdfapplication/pdf9731428https://www.arca.fiocruz.br/bitstream/icict/25140/2/Lipophosphoglycan%20polymorphisms%20do%20not%20affect%20Leishmania%20amazonensis%20development%20in%20the%20permissive%20vectors%20Lutzomyia%20migonei%20and%20Lutzomyia%20longipalpis.pdf28013038b15bcc756ec7a80516e580acMD52TEXTLipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpis.pdf.txtLipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpis.pdf.txtExtracted texttext/plain37https://www.arca.fiocruz.br/bitstream/icict/25140/3/Lipophosphoglycan%20polymorphisms%20do%20not%20affect%20Leishmania%20amazonensis%20development%20in%20the%20permissive%20vectors%20Lutzomyia%20migonei%20and%20Lutzomyia%20longipalpis.pdf.txtb130d4c212658bef64e054897b6c6414MD53icict/251402019-06-19 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dc.title.pt_BR.fl_str_mv Lipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpis
title Lipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpis
spellingShingle Lipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpis
Nogueira, Paula Monalisa
Leishmania amazonensis
Lutzomyia longipalpis
Lutzomyia migonei
Phlebotomus papatasi
Leishmania amazonensis
Lipophosphoglycan
Lutzomyia longipalpis
Lutzomyia migonei
Phlebotomus papatasi
Vector-parasite interaction
title_short Lipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpis
title_full Lipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpis
title_fullStr Lipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpis
title_full_unstemmed Lipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpis
title_sort Lipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpis
author Nogueira, Paula Monalisa
author_facet Nogueira, Paula Monalisa
Guimarães, Agna Cristina
Assis, Rafael Ramiro de
Sadlova, Jovana
Myskova, Jitka
Pruzinova, Katerina
Hlavackova, Jana
Turco, Salvatore J.
Torrecilhas, Ana Claudia Trocoli
Volf, Petr
Soares, Rodrigo Pedro Pinto
author_role author
author2 Guimarães, Agna Cristina
Assis, Rafael Ramiro de
Sadlova, Jovana
Myskova, Jitka
Pruzinova, Katerina
Hlavackova, Jana
Turco, Salvatore J.
Torrecilhas, Ana Claudia Trocoli
Volf, Petr
Soares, Rodrigo Pedro Pinto
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nogueira, Paula Monalisa
Guimarães, Agna Cristina
Assis, Rafael Ramiro de
Sadlova, Jovana
Myskova, Jitka
Pruzinova, Katerina
Hlavackova, Jana
Turco, Salvatore J.
Torrecilhas, Ana Claudia Trocoli
Volf, Petr
Soares, Rodrigo Pedro Pinto
dc.subject.other.pt_BR.fl_str_mv Leishmania amazonensis
Lutzomyia longipalpis
Lutzomyia migonei
Phlebotomus papatasi
topic Leishmania amazonensis
Lutzomyia longipalpis
Lutzomyia migonei
Phlebotomus papatasi
Leishmania amazonensis
Lipophosphoglycan
Lutzomyia longipalpis
Lutzomyia migonei
Phlebotomus papatasi
Vector-parasite interaction
dc.subject.en.pt_BR.fl_str_mv Leishmania amazonensis
Lipophosphoglycan
Lutzomyia longipalpis
Lutzomyia migonei
Phlebotomus papatasi
Vector-parasite interaction
description Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG Brazil/Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-03-07T16:36:12Z
dc.date.available.fl_str_mv 2018-03-07T16:36:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv NOGUEIRA, Paula Monalisa et al. Lipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpis. Parasit Vectors, v. 10, n. 1, p. 608, 2017
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25140
dc.identifier.issn.pt_BR.fl_str_mv 1756-3305
dc.identifier.doi.none.fl_str_mv 10.1186/s13071-017-2568-8
identifier_str_mv NOGUEIRA, Paula Monalisa et al. Lipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpis. Parasit Vectors, v. 10, n. 1, p. 608, 2017
1756-3305
10.1186/s13071-017-2568-8
url https://www.arca.fiocruz.br/handle/icict/25140
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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