Cytokines and visceral leishmaniasis: a comparison of plasma cytokine profiles between the clinical forms of visceral leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Costa, Alinne Silva Andrade
Data de Publicação: 2012
Outros Autores: Costa, Graciomar Conceição, Aquino, Dorlene Maria Cardoso de, Mendonça, Vitor Rosa Ramos de, Barral, Aldina Maria Prado, Barral Netto, Manoel, Caldas, Arlene de Jesus Mendes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5952
Resumo: Universidade Federal do Maranhão. Departamento de Saúde Pública. São Luís, MA, Brasil
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spelling Costa, Alinne Silva AndradeCosta, Graciomar ConceiçãoAquino, Dorlene Maria Cardoso deMendonça, Vitor Rosa Ramos deBarral, Aldina Maria PradoBarral Netto, ManoelCaldas, Arlene de Jesus Mendes2012-12-10T21:13:47Z2012-12-10T21:13:47Z2012COSTA, A. S. A. et al. Cytokines and visceral leishmaniasis: a comparison of plasma cytokine profiles between the clinical forms of visceral leishmaniasis. Memórias do Instituo Oswaldo Cruz, v. 107, n. 6, p. 735-739, sept. 2012.0074-0276https://www.arca.fiocruz.br/handle/icict/5952engCytokines and visceral leishmaniasis: a comparison of plasma cytokine profiles between the clinical forms of visceral leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Maranhão. Departamento de Saúde Pública. São Luís, MA, BrasilUniversidade Federal do Maranhão. Departamento de PatologiaSaúde Pública. São Luís, MA, BrasilUniversidade Federal do Maranhão. Departamento de Enfermagem. São Luís, MA, BrasilUniversidade Federal do Maranhão. São Luís, MA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal do Maranhão. Departamento de PatologiaSaúde Pública. São Luís, MA, Brasilt is not well established whether cytokine production differs in response to different clinical forms of visceral leishmaniasis (VL). In this work, we performed a cross-sectional study to investigate the plasma levels of cytokines [interferon (IFN)-γ, tumour necrosis factor (TNF)-α, interleukin (IL)-2, IL-4, IL-10 and IL-12] involved in the pathogenesis of VL in 80 subjects from VL endemic areas, including subjects with active VL, subjects with asymptomatic infection, subjects with cured VL and uninfected controls. The patients were recruited by sampling from a referral hospital and by random selection from a population-based cohort study. The results showed significant differences in the plasma concentration of all cytokines between the groups (p < 0.05). Patients with the active disease had higher plasma levels of IL-10, IL-4, INF-γ and TNF-α relative to the other groups and they produced more IL-12 than asymptomatic and cured subjects. Only the IL-2 concentration was higher in the asymptomatic and cured subjects relative to the patients with active disease (p < 0.05). Our results suggest that these cytokines can be used as markers in epidemiological studies conducted in endemic areas to distinguish between different clinical forms of VL. However, their usefulness should be confirmed in investigations conducted in other endemic areas.(CytokinesVisceral leishmaniasisClinical formsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCosta, Alinne Silva Andrade et al and Cytokines and visceral....pdfCosta, Alinne Silva Andrade et al and Cytokines and visceral....pdfapplication/pdf384267https://www.arca.fiocruz.br/bitstream/icict/5952/1/Costa%2c%20Alinne%20Silva%20Andrade%20et%20al%20and%20Cytokines%20and%20visceral....pdf14a53ebe6c7bdab9456aaace484adc40MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81949https://www.arca.fiocruz.br/bitstream/icict/5952/2/license.txtaad6e5ff39a8b3723a1981fb3bcd1becMD52TEXTCosta, Alinne Silva Andrade et al and Cytokines and visceral....pdf.txtCosta, Alinne Silva Andrade et al and Cytokines and visceral....pdf.txtExtracted texttext/plain26427https://www.arca.fiocruz.br/bitstream/icict/5952/5/Costa%2c%20Alinne%20Silva%20Andrade%20et%20al%20and%20Cytokines%20and%20visceral....pdf.txt091f096b51bf54fa0f3d5b5140c63827MD55THUMBNAILCosta, Alinne Silva Andrade et al and Cytokines and visceral....pdf.jpgCosta, Alinne Silva Andrade et al and Cytokines and visceral....pdf.jpgGenerated Thumbnailimage/jpeg2193https://www.arca.fiocruz.br/bitstream/icict/5952/4/Costa%2c%20Alinne%20Silva%20Andrade%20et%20al%20and%20Cytokines%20and%20visceral....pdf.jpgab271d8ebc636e7c2f3743bfc7c95c32MD54icict/59522023-03-15 14:33:15.623oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:15Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Cytokines and visceral leishmaniasis: a comparison of plasma cytokine profiles between the clinical forms of visceral leishmaniasis
title Cytokines and visceral leishmaniasis: a comparison of plasma cytokine profiles between the clinical forms of visceral leishmaniasis
spellingShingle Cytokines and visceral leishmaniasis: a comparison of plasma cytokine profiles between the clinical forms of visceral leishmaniasis
Costa, Alinne Silva Andrade
Cytokines
Visceral leishmaniasis
Clinical forms
title_short Cytokines and visceral leishmaniasis: a comparison of plasma cytokine profiles between the clinical forms of visceral leishmaniasis
title_full Cytokines and visceral leishmaniasis: a comparison of plasma cytokine profiles between the clinical forms of visceral leishmaniasis
title_fullStr Cytokines and visceral leishmaniasis: a comparison of plasma cytokine profiles between the clinical forms of visceral leishmaniasis
title_full_unstemmed Cytokines and visceral leishmaniasis: a comparison of plasma cytokine profiles between the clinical forms of visceral leishmaniasis
title_sort Cytokines and visceral leishmaniasis: a comparison of plasma cytokine profiles between the clinical forms of visceral leishmaniasis
author Costa, Alinne Silva Andrade
author_facet Costa, Alinne Silva Andrade
Costa, Graciomar Conceição
Aquino, Dorlene Maria Cardoso de
Mendonça, Vitor Rosa Ramos de
Barral, Aldina Maria Prado
Barral Netto, Manoel
Caldas, Arlene de Jesus Mendes
author_role author
author2 Costa, Graciomar Conceição
Aquino, Dorlene Maria Cardoso de
Mendonça, Vitor Rosa Ramos de
Barral, Aldina Maria Prado
Barral Netto, Manoel
Caldas, Arlene de Jesus Mendes
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa, Alinne Silva Andrade
Costa, Graciomar Conceição
Aquino, Dorlene Maria Cardoso de
Mendonça, Vitor Rosa Ramos de
Barral, Aldina Maria Prado
Barral Netto, Manoel
Caldas, Arlene de Jesus Mendes
dc.subject.en.pt_BR.fl_str_mv Cytokines
Visceral leishmaniasis
Clinical forms
topic Cytokines
Visceral leishmaniasis
Clinical forms
description Universidade Federal do Maranhão. Departamento de Saúde Pública. São Luís, MA, Brasil
publishDate 2012
dc.date.accessioned.fl_str_mv 2012-12-10T21:13:47Z
dc.date.available.fl_str_mv 2012-12-10T21:13:47Z
dc.date.issued.fl_str_mv 2012
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv COSTA, A. S. A. et al. Cytokines and visceral leishmaniasis: a comparison of plasma cytokine profiles between the clinical forms of visceral leishmaniasis. Memórias do Instituo Oswaldo Cruz, v. 107, n. 6, p. 735-739, sept. 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5952
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv COSTA, A. S. A. et al. Cytokines and visceral leishmaniasis: a comparison of plasma cytokine profiles between the clinical forms of visceral leishmaniasis. Memórias do Instituo Oswaldo Cruz, v. 107, n. 6, p. 735-739, sept. 2012.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/5952
dc.language.iso.fl_str_mv eng
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