Spatiotemporal Dynamics of DENV-2 Asian-American Genotype Lineages in the Americas

Detalhes bibliográficos
Autor(a) principal: Mir, Daiana
Data de Publicação: 2014
Outros Autores: Romero, Hector, Carvalho, Luiz Max Fagundes de, Bello, Gustavo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9974
Resumo: Universidad de la República. Facultad de Ciencias CURE. Dpto. Ecologıa y Evolución. Laboratorio de Organización y Evolución del Genoma. Montevideo, Uruguay
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spelling Mir, DaianaRomero, HectorCarvalho, Luiz Max Fagundes deBello, Gustavo2015-04-14T12:38:11Z2015-04-14T12:38:11Z2014MIR, Daiana et al. Spatiotemporal Dynamics of DENV-2 Asian-American Genotype Lineages in the Americas. Plos One, v.9, n.6, jun. 2014https://www.arca.fiocruz.br/handle/icict/9974DOI: 10.1371/journal.pone.0098519engPlos OneGenótipoDengueAméricasGenotypeDengueAmericasGenotipoDengueAmericasSpatiotemporal Dynamics of DENV-2 Asian-American Genotype Lineages in the Americasinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidad de la República. Facultad de Ciencias CURE. Dpto. Ecologıa y Evolución. Laboratorio de Organización y Evolución del Genoma. Montevideo, UruguayUniversidad de la República. Facultad de Ciencias CURE. Dpto. Ecologıa y Evolución. Laboratorio de Organización y Evolución del Genoma. Montevideo, UruguayFundação Oswaldo Cruz. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil.The Asian/American (AS/AM) genotype of dengue virus type 2 (DENV-2) has been evolving in the Americas over the last 30 years, leading to several waves of dengue epidemics and to the emergence of different viral lineages in the region. In this study, we investigate the spatiotemporal dissemination pattern of the DENV-2 lineages at a regional level. We applied phylogenetic and phylogeographic analytical methods to a comprehensive data set of 582 DENV-2 E gene sequences of the AS/AM genotype isolated from 29 different American countries over a period of 30 years (1983 to 2012). Our study reveals that genetic diversity of DENV-2 AS/AM genotype circulating in the Americas mainly resulted from one single founder event and can be organized in at least four major lineages (I to IV), which emerged in the Caribbean region at the early 1980s and then spread and die out with different dynamics. Lineages I and II dominate the epidemics in the Caribbean region during the 1980s and early 1990s, lineage III becomes the prevalent DENV-2 one in the Caribbean and South America during the 1990s, whereas lineage IV dominates the epidemics in South and Central America during the 2000s. Suriname and Guyana seem to represent important entry points for DENV-2 from the Lesser Antilles to South America, whereas Venezuela, Brazil and Nicaragua were pointed as the main secondary hubs of dissemination to other mainland countries. Our study also indicates that DENV-2 AS/AM genotype was disseminated within South America following two main routes. The first route hits Venezuela and the western side of the Andes, while the second route mainly hits Brazil and the eastern side of the Andes. The phenomenon of DENV-2 lineage replacement across successive epidemic outbreaks was a common characteristic in all American countries, although the timing of lineage replacements greatly vary across locations.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/9974/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALgonzalo_belloetal2_IOC-2014.pdfapplication/pdf1214945https://www.arca.fiocruz.br/bitstream/icict/9974/2/gonzalo_belloetal2_IOC-2014.pdfd286e872af8578a3a125eadcc9975729MD52TEXTgonzalo_belloetal2_IOC-2014.pdf.txtgonzalo_belloetal2_IOC-2014.pdf.txtExtracted texttext/plain44164https://www.arca.fiocruz.br/bitstream/icict/9974/3/gonzalo_belloetal2_IOC-2014.pdf.txt66af56fead477c9d668939e9953f3923MD53icict/99742022-06-24 13:08:46.485oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:08:46Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Spatiotemporal Dynamics of DENV-2 Asian-American Genotype Lineages in the Americas
title Spatiotemporal Dynamics of DENV-2 Asian-American Genotype Lineages in the Americas
spellingShingle Spatiotemporal Dynamics of DENV-2 Asian-American Genotype Lineages in the Americas
Mir, Daiana
Genótipo
Dengue
Américas
Genotype
Dengue
Americas
Genotipo
Dengue
Americas
title_short Spatiotemporal Dynamics of DENV-2 Asian-American Genotype Lineages in the Americas
title_full Spatiotemporal Dynamics of DENV-2 Asian-American Genotype Lineages in the Americas
title_fullStr Spatiotemporal Dynamics of DENV-2 Asian-American Genotype Lineages in the Americas
title_full_unstemmed Spatiotemporal Dynamics of DENV-2 Asian-American Genotype Lineages in the Americas
title_sort Spatiotemporal Dynamics of DENV-2 Asian-American Genotype Lineages in the Americas
author Mir, Daiana
author_facet Mir, Daiana
Romero, Hector
Carvalho, Luiz Max Fagundes de
Bello, Gustavo
author_role author
author2 Romero, Hector
Carvalho, Luiz Max Fagundes de
Bello, Gustavo
author2_role author
author
author
dc.contributor.author.fl_str_mv Mir, Daiana
Romero, Hector
Carvalho, Luiz Max Fagundes de
Bello, Gustavo
dc.subject.other.pt_BR.fl_str_mv Genótipo
Dengue
Américas
topic Genótipo
Dengue
Américas
Genotype
Dengue
Americas
Genotipo
Dengue
Americas
dc.subject.en.pt_BR.fl_str_mv Genotype
Dengue
Americas
dc.subject.es.pt_BR.fl_str_mv Genotipo
Dengue
Americas
description Universidad de la República. Facultad de Ciencias CURE. Dpto. Ecologıa y Evolución. Laboratorio de Organización y Evolución del Genoma. Montevideo, Uruguay
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-04-14T12:38:11Z
dc.date.available.fl_str_mv 2015-04-14T12:38:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MIR, Daiana et al. Spatiotemporal Dynamics of DENV-2 Asian-American Genotype Lineages in the Americas. Plos One, v.9, n.6, jun. 2014
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9974
dc.identifier.doi.pt_BR.fl_str_mv DOI: 10.1371/journal.pone.0098519
identifier_str_mv MIR, Daiana et al. Spatiotemporal Dynamics of DENV-2 Asian-American Genotype Lineages in the Americas. Plos One, v.9, n.6, jun. 2014
DOI: 10.1371/journal.pone.0098519
url https://www.arca.fiocruz.br/handle/icict/9974
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Plos One
publisher.none.fl_str_mv Plos One
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