Frequency, active infection and load of Leishmania infantum and associated histological alterations in the genital tract of male and female dogs
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/43558 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil. |
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Boechat, Viviane CardosoPereira, Sandro AntonioMendes Júnior, Artur Augusto VelhoSantos, Shanna Araujo dosMiranda, Luciana de Freitas CamposFigueiredo, Fabiano BorgesFerreira, Luiz ClaudioRodrigues, Francisco das Chagas de CarvalhoOliveira, Raquel de Vasconcellos Carvalhaes deTeles -de-Freitas, RayaneBruno, Rafaela VieiraMorgado, Fernanda NazaréMenezes, Rodrigo Caldas2020-09-22T20:24:52Z2020-09-22T20:24:52Z2020BOECHAT, Viviane Cardoso et al. Frequency, active infection and load of Leishmania infantum and associated histological alterations in the genital tract of male and female dog. PLoS One, v. 15, n. 9, p. 1-18, 2020.1932-6203https://www.arca.fiocruz.br/handle/icict/4355810.1371/journal.pone.0238188porPublic Library of ScienceFrequency, active infection and load of Leishmania infantum and associated histological alterations in the genital tract of male and female dogsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Epidemiologia Clínica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Insetos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Insetos. Rio de Janeiro, RJ, Brasil. / Ministério de Ciência Tecnologia e Inovação. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Visceral leishmaniasis caused by the protozoan Leishmania infantum is a zoonosis. The domestic dog is the primary reservoir in urban areas. This study aimed to evaluate the frequency, active infection and load of L. infantum in the genital tract of male and female dogs seropositive for this parasite, as well as to identify histological genital alterations associated with this protozoan. We studied 45 male and 25 female L. infantum-seropositive non castrated dogs from the same endemic area in Brazil. Tissue samples from the testis, epididymis, prostate, vulva, vagina, and uterus were examined by singleplex qPCR and parasitological tests (histopathology, immunohistochemistry, and parasitological culture). The latter were performed for the detection of active infection (parasites able to multiply and to induce lesions). Forty-four (98%) males and 25 (100%) females were positive for L. infantum in the genital tract (epididymis: 98%; vulva: 92%; vagina: 92%; testis: 91%; uterus: 84%; prostate: 66%). Active infection in the genital tract was confirmed in 69% of males and 64% of females (32% in the uterus). Parasite loads were similar in the testis, vulva, epididymis and vagina and lower in the prostate. Only the parasite load in the vagina was significantly associated with the number of clinical signs. Granulomatous inflammation predominated in all organs, except for the prostate. Only in the testis and epididymis was the inflammatory infiltrate significantly more intense among dogs with a higher parasite load in these organs. The high frequency, detection of active infection and similarity of L. infantum loads in the genital tract of infected males and females suggest the potential of venereal transmission of this parasite by both sexes and of vertical transmission by females in the area studied. Additionally, vertical transmission may be frequent since active L. infantum infection was a common observation in the uterus.Leishmaniasis, VisceralDogsReproductive Tract InfectionsInfectious Disease Transmission, VerticalLeishmaniasis VisceralPerrosInfecciones del Sistema GenitalTransmisión Vertical de Enfermedad InfecciosaLeishmaniose viscéraleChiensInfections de l'appareil reproducteurTransmission verticale de maladie infectieuseLeishmaniose VisceralCãesInfecções do Sistema GenitalTransmissão Vertical de Doença Infecciosainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Frequency, active infection and load of Leishmania infantum and associated histological alterations in the genital tract of male and female dogs |
title |
Frequency, active infection and load of Leishmania infantum and associated histological alterations in the genital tract of male and female dogs |
spellingShingle |
Frequency, active infection and load of Leishmania infantum and associated histological alterations in the genital tract of male and female dogs Boechat, Viviane Cardoso Leishmaniasis, Visceral Dogs Reproductive Tract Infections Infectious Disease Transmission, Vertical Leishmaniasis Visceral Perros Infecciones del Sistema Genital Transmisión Vertical de Enfermedad Infecciosa Leishmaniose viscérale Chiens Infections de l'appareil reproducteur Transmission verticale de maladie infectieuse Leishmaniose Visceral Cães Infecções do Sistema Genital Transmissão Vertical de Doença Infecciosa |
title_short |
Frequency, active infection and load of Leishmania infantum and associated histological alterations in the genital tract of male and female dogs |
title_full |
Frequency, active infection and load of Leishmania infantum and associated histological alterations in the genital tract of male and female dogs |
title_fullStr |
Frequency, active infection and load of Leishmania infantum and associated histological alterations in the genital tract of male and female dogs |
title_full_unstemmed |
Frequency, active infection and load of Leishmania infantum and associated histological alterations in the genital tract of male and female dogs |
title_sort |
Frequency, active infection and load of Leishmania infantum and associated histological alterations in the genital tract of male and female dogs |
author |
Boechat, Viviane Cardoso |
author_facet |
Boechat, Viviane Cardoso Pereira, Sandro Antonio Mendes Júnior, Artur Augusto Velho Santos, Shanna Araujo dos Miranda, Luciana de Freitas Campos Figueiredo, Fabiano Borges Ferreira, Luiz Claudio Rodrigues, Francisco das Chagas de Carvalho Oliveira, Raquel de Vasconcellos Carvalhaes de Teles -de-Freitas, Rayane Bruno, Rafaela Vieira Morgado, Fernanda Nazaré Menezes, Rodrigo Caldas |
author_role |
author |
author2 |
Pereira, Sandro Antonio Mendes Júnior, Artur Augusto Velho Santos, Shanna Araujo dos Miranda, Luciana de Freitas Campos Figueiredo, Fabiano Borges Ferreira, Luiz Claudio Rodrigues, Francisco das Chagas de Carvalho Oliveira, Raquel de Vasconcellos Carvalhaes de Teles -de-Freitas, Rayane Bruno, Rafaela Vieira Morgado, Fernanda Nazaré Menezes, Rodrigo Caldas |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Boechat, Viviane Cardoso Pereira, Sandro Antonio Mendes Júnior, Artur Augusto Velho Santos, Shanna Araujo dos Miranda, Luciana de Freitas Campos Figueiredo, Fabiano Borges Ferreira, Luiz Claudio Rodrigues, Francisco das Chagas de Carvalho Oliveira, Raquel de Vasconcellos Carvalhaes de Teles -de-Freitas, Rayane Bruno, Rafaela Vieira Morgado, Fernanda Nazaré Menezes, Rodrigo Caldas |
dc.subject.en.pt_BR.fl_str_mv |
Leishmaniasis, Visceral Dogs Reproductive Tract Infections Infectious Disease Transmission, Vertical |
topic |
Leishmaniasis, Visceral Dogs Reproductive Tract Infections Infectious Disease Transmission, Vertical Leishmaniasis Visceral Perros Infecciones del Sistema Genital Transmisión Vertical de Enfermedad Infecciosa Leishmaniose viscérale Chiens Infections de l'appareil reproducteur Transmission verticale de maladie infectieuse Leishmaniose Visceral Cães Infecções do Sistema Genital Transmissão Vertical de Doença Infecciosa |
dc.subject.es.pt_BR.fl_str_mv |
Leishmaniasis Visceral Perros Infecciones del Sistema Genital Transmisión Vertical de Enfermedad Infecciosa |
dc.subject.fr.pt_BR.fl_str_mv |
Leishmaniose viscérale Chiens Infections de l'appareil reproducteur Transmission verticale de maladie infectieuse |
dc.subject.decs.pt_BR.fl_str_mv |
Leishmaniose Visceral Cães Infecções do Sistema Genital Transmissão Vertical de Doença Infecciosa |
description |
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-09-22T20:24:52Z |
dc.date.available.fl_str_mv |
2020-09-22T20:24:52Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
BOECHAT, Viviane Cardoso et al. Frequency, active infection and load of Leishmania infantum and associated histological alterations in the genital tract of male and female dog. PLoS One, v. 15, n. 9, p. 1-18, 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/43558 |
dc.identifier.issn.pt_BR.fl_str_mv |
1932-6203 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1371/journal.pone.0238188 |
identifier_str_mv |
BOECHAT, Viviane Cardoso et al. Frequency, active infection and load of Leishmania infantum and associated histological alterations in the genital tract of male and female dog. PLoS One, v. 15, n. 9, p. 1-18, 2020. 1932-6203 10.1371/journal.pone.0238188 |
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https://www.arca.fiocruz.br/handle/icict/43558 |
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Public Library of Science |
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Public Library of Science |
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