Insecticide resistance and underlying targets‑site and metabolic mechanisms in Aedes aegypti and Aedes albopictus from Lahore, Pakistan
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46526 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil. |
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Rahman, Rafi UrSouza, BarbaraUddin, IftikharCarrara, LuanaBrito, Luiz PauloCosta, Monique MeloMahmood, Muhammad AsifKhan, SozainaLima, José Bento PereiraMartins, Ademir Jesus2021-04-06T19:39:46Z2021-04-06T19:39:46Z2021RAHMAN, Rafi Ur et al. Insecticide resistance and underlying targets‑site and metabolic mechanisms in Aedes aegypti and Aedes albopictus from Lahore, Pakistan. Scientifc Reports, v. 11, p. 1-15, 2021.2045-2322https://www.arca.fiocruz.br/handle/icict/4652610.1038/s41598-021-83465-wengNatureAedes aegyptiAedes albopictusResistência a InseticidasLahore, PakistanMecanismos metabólicosInsecticide resistanceAedes aegyptiAedes albopictusLahore, PakistanMetabolic mechanismsInsecticide resistance and underlying targets‑site and metabolic mechanisms in Aedes aegypti and Aedes albopictus from Lahore, Pakistaninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil.Community Medicine Department, Bacha Khan Medical College Mardan. Mardan, Pakistan.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil.Institute of Public Health. Lahore, Pakistan..Zoology Department, Government College University. Lahore, Pakistan.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. INCT-EM, UFRJ, Rio de Janeiro, RJ, Brasil.Insecticide resistant Aedes populations have recently been reported in Pakistan, imposing a threat to their control. We aimed to evaluate the susceptibility of Aedes aegypti and Aedes albopictus populations from Lahore to WHO-recommended insecticides and to investigate metabolic and target-site resistance mechanisms. For this purpose, we first carried out bioassays with the larvicides temephos and pyriproxyfen, and the adulticides malathion, permethrin, deltamethrin, alphacypermethrin, and etofenprox. We looked for Knockdown resistance mutations (kdr) by qPCR, High-Resolution Melt (HRM), and sequencing. In order to explore the role of detoxifying enzymes in resistance, we carried out synergist bioassay with both species and then checked the expression of CYP9M6, CYP9J10, CYP9J28, CYP6BB2, CCAe3a, and SAP2 genes in Ae. aegypti. Both species were susceptible to organophosphates and the insect growth regulator, however resistant to all pyrethroids. We are reporting the kdr haplotypes 1520Ile + 1534Cys and T1520 + 1534Cys in high frequencies in Ae. aegypti while Ae. albopictus only exhibited the alteration L882M. PBO increased the sensitivity to permethrin in Ae. aegypti, suggesting the participation of P450 genes in conferring resistance, and indeed, CYP928 was highly expressed. We presume that dengue vectors in Lahore city are resistant to pyrethroids, probably due to multiple mechanisms, such as kdr mutations and P450 overexpression.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/46526/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJoseBLima_AMArtins_etal_IOC_2021.pdfJoseBLima_AMArtins_etal_IOC_2021.pdfapplication/pdf2224486https://www.arca.fiocruz.br/bitstream/icict/46526/2/JoseBLima_AMArtins_etal_IOC_2021.pdfd983c94df3baf353d72e0389d111d142MD52TEXTJoseBLima_AMArtins_etal_IOC_2021.pdf.txtJoseBLima_AMArtins_etal_IOC_2021.pdf.txtExtracted texttext/plain78375https://www.arca.fiocruz.br/bitstream/icict/46526/3/JoseBLima_AMArtins_etal_IOC_2021.pdf.txt58921ed99a9845bfc1ca7935630409bdMD53icict/465262021-04-07 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dc.title.pt_BR.fl_str_mv |
Insecticide resistance and underlying targets‑site and metabolic mechanisms in Aedes aegypti and Aedes albopictus from Lahore, Pakistan |
title |
Insecticide resistance and underlying targets‑site and metabolic mechanisms in Aedes aegypti and Aedes albopictus from Lahore, Pakistan |
spellingShingle |
Insecticide resistance and underlying targets‑site and metabolic mechanisms in Aedes aegypti and Aedes albopictus from Lahore, Pakistan Rahman, Rafi Ur Aedes aegypti Aedes albopictus Resistência a Inseticidas Lahore, Pakistan Mecanismos metabólicos Insecticide resistance Aedes aegypti Aedes albopictus Lahore, Pakistan Metabolic mechanisms |
title_short |
Insecticide resistance and underlying targets‑site and metabolic mechanisms in Aedes aegypti and Aedes albopictus from Lahore, Pakistan |
title_full |
Insecticide resistance and underlying targets‑site and metabolic mechanisms in Aedes aegypti and Aedes albopictus from Lahore, Pakistan |
title_fullStr |
Insecticide resistance and underlying targets‑site and metabolic mechanisms in Aedes aegypti and Aedes albopictus from Lahore, Pakistan |
title_full_unstemmed |
Insecticide resistance and underlying targets‑site and metabolic mechanisms in Aedes aegypti and Aedes albopictus from Lahore, Pakistan |
title_sort |
Insecticide resistance and underlying targets‑site and metabolic mechanisms in Aedes aegypti and Aedes albopictus from Lahore, Pakistan |
author |
Rahman, Rafi Ur |
author_facet |
Rahman, Rafi Ur Souza, Barbara Uddin, Iftikhar Carrara, Luana Brito, Luiz Paulo Costa, Monique Melo Mahmood, Muhammad Asif Khan, Sozaina Lima, José Bento Pereira Martins, Ademir Jesus |
author_role |
author |
author2 |
Souza, Barbara Uddin, Iftikhar Carrara, Luana Brito, Luiz Paulo Costa, Monique Melo Mahmood, Muhammad Asif Khan, Sozaina Lima, José Bento Pereira Martins, Ademir Jesus |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Rahman, Rafi Ur Souza, Barbara Uddin, Iftikhar Carrara, Luana Brito, Luiz Paulo Costa, Monique Melo Mahmood, Muhammad Asif Khan, Sozaina Lima, José Bento Pereira Martins, Ademir Jesus |
dc.subject.other.pt_BR.fl_str_mv |
Aedes aegypti Aedes albopictus Resistência a Inseticidas Lahore, Pakistan Mecanismos metabólicos |
topic |
Aedes aegypti Aedes albopictus Resistência a Inseticidas Lahore, Pakistan Mecanismos metabólicos Insecticide resistance Aedes aegypti Aedes albopictus Lahore, Pakistan Metabolic mechanisms |
dc.subject.en.pt_BR.fl_str_mv |
Insecticide resistance Aedes aegypti Aedes albopictus Lahore, Pakistan Metabolic mechanisms |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-04-06T19:39:46Z |
dc.date.available.fl_str_mv |
2021-04-06T19:39:46Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
RAHMAN, Rafi Ur et al. Insecticide resistance and underlying targets‑site and metabolic mechanisms in Aedes aegypti and Aedes albopictus from Lahore, Pakistan. Scientifc Reports, v. 11, p. 1-15, 2021. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/46526 |
dc.identifier.issn.pt_BR.fl_str_mv |
2045-2322 |
dc.identifier.doi.none.fl_str_mv |
10.1038/s41598-021-83465-w |
identifier_str_mv |
RAHMAN, Rafi Ur et al. Insecticide resistance and underlying targets‑site and metabolic mechanisms in Aedes aegypti and Aedes albopictus from Lahore, Pakistan. Scientifc Reports, v. 11, p. 1-15, 2021. 2045-2322 10.1038/s41598-021-83465-w |
url |
https://www.arca.fiocruz.br/handle/icict/46526 |
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eng |
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eng |
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Nature |
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Nature |
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