Antitumour Activity of the Microencapsulation of Annona
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/13240 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Bomfim, Larissa MendesMenezes, Leociley Rocha AlencarRodrigues, Ana Carolina B. CDias, Rosane BorgesRocha, Clarissa Araújo GurgelSoares, Milena Botelho PereiraSantana Neto, Albertino FreitasNascimento, Magaly PintoCampos, Adriana FSilva, Lidercia Cavalcanti Ribeiro Cerqueira eCosta, Emmanoel VilaçaBezerra, Daniel Pereira2016-03-22T14:38:02Z2016-03-22T14:38:02Z2016BOMFIM, L. M. et al. Antitumour Activity of the Microencapsulation of Annona. Basic & Clinical Pharmacology Toxicology, v. 118, n. 3, p. 208-213, 2016.1742-784310.1111/bcpt.12488https://www.arca.fiocruz.br/handle/icict/13240engWileyAnnonaAnnonaceaeÓleos essenciaisCitotoxicidadeAnticorpos antitumorMicroencapsulaçãoRatosAntitumour Activity of the Microencapsulation of Annonainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFederal University of Sergipe. Department of Chemistry. São Crist ovão, SE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Department of Propedeutics. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, BrasilFederal University of Bahia. Faculty of Pharmacy. Salvador, BA, BrasilNortheastern Center for Strategic Technologies. CETENE. Recife, PE, BrasilNortheastern Center for Strategic Technologies. CETENE. Recife, PE, BrasilFederal University of Bahia. Faculty of Pharmacy. Salvador, BA, BrasilFederal University of Amazonas. Department of Chemistry. Manaus, AM, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilAnnona vepretorum Mart. (Annonaceae), popularly known as ‘bruteira’, has nutritional and medicinal uses. This study investigated the chemical composition and antitumour potential of the essential oil of A. vepretorum leaf alone and complexed with b-cyclodextrin in a microencapsulation. The essential oil was obtained by hydrodistillation using a Clevenger-type apparatus and analysed using GC-MS and GC-FID. In vitro cytotoxicity of the essential oil and some of its major constituents in tumour cell lines from different histotypes was evaluated using the alamar blue assay. Furthermore, the in vivo efficacy of essential oil was demonstrated in mice inoculated with B16-F10 mouse melanoma. The essential oil included bicyclogermacrene (35.71%), spathulenol (18.89%), (E)-b-ocimene (12.46%), a-phellandrene (8.08%), o-cymene (6.24%), germacrene D (3.27%) and a-pinene (2.18%) as major constituents. The essential oil and spathulenol exhibited promising cytotoxicity. In vivo tumour growth was inhibited by the treatment with the essential oil (inhibition of 34.46%). Importantly, microencapsulation of the essential oil increased in vivo tumour growth inhibition (inhibition of 62.66%).info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13240/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBomfim LM Antitumour activity....pdfBomfim LM Antitumour activity....pdfapplication/pdf268347https://www.arca.fiocruz.br/bitstream/icict/13240/2/Bomfim%20LM%20Antitumour%20activity....pdfb5e018b310bd4ccf7c41467e2c38272cMD52TEXTBomfim LM Antitumour activity....pdf.txtBomfim LM Antitumour activity....pdf.txtExtracted texttext/plain33879https://www.arca.fiocruz.br/bitstream/icict/13240/3/Bomfim%20LM%20Antitumour%20activity....pdf.txt98e61970adbcd3336a4c06323dc2327fMD53icict/132402023-03-15 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| dc.title.pt_BR.fl_str_mv |
Antitumour Activity of the Microencapsulation of Annona |
| title |
Antitumour Activity of the Microencapsulation of Annona |
| spellingShingle |
Antitumour Activity of the Microencapsulation of Annona Bomfim, Larissa Mendes Annona Annonaceae Óleos essenciais Citotoxicidade Anticorpos antitumor Microencapsulação Ratos |
| title_short |
Antitumour Activity of the Microencapsulation of Annona |
| title_full |
Antitumour Activity of the Microencapsulation of Annona |
| title_fullStr |
Antitumour Activity of the Microencapsulation of Annona |
| title_full_unstemmed |
Antitumour Activity of the Microencapsulation of Annona |
| title_sort |
Antitumour Activity of the Microencapsulation of Annona |
| author |
Bomfim, Larissa Mendes |
| author_facet |
Bomfim, Larissa Mendes Menezes, Leociley Rocha Alencar Rodrigues, Ana Carolina B. C Dias, Rosane Borges Rocha, Clarissa Araújo Gurgel Soares, Milena Botelho Pereira Santana Neto, Albertino Freitas Nascimento, Magaly Pinto Campos, Adriana F Silva, Lidercia Cavalcanti Ribeiro Cerqueira e Costa, Emmanoel Vilaça Bezerra, Daniel Pereira |
| author_role |
author |
| author2 |
Menezes, Leociley Rocha Alencar Rodrigues, Ana Carolina B. C Dias, Rosane Borges Rocha, Clarissa Araújo Gurgel Soares, Milena Botelho Pereira Santana Neto, Albertino Freitas Nascimento, Magaly Pinto Campos, Adriana F Silva, Lidercia Cavalcanti Ribeiro Cerqueira e Costa, Emmanoel Vilaça Bezerra, Daniel Pereira |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bomfim, Larissa Mendes Menezes, Leociley Rocha Alencar Rodrigues, Ana Carolina B. C Dias, Rosane Borges Rocha, Clarissa Araújo Gurgel Soares, Milena Botelho Pereira Santana Neto, Albertino Freitas Nascimento, Magaly Pinto Campos, Adriana F Silva, Lidercia Cavalcanti Ribeiro Cerqueira e Costa, Emmanoel Vilaça Bezerra, Daniel Pereira |
| dc.subject.other.pt_BR.fl_str_mv |
Annona Annonaceae Óleos essenciais Citotoxicidade Anticorpos antitumor Microencapsulação Ratos |
| topic |
Annona Annonaceae Óleos essenciais Citotoxicidade Anticorpos antitumor Microencapsulação Ratos |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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2016 |
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2016-03-22T14:38:02Z |
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2016-03-22T14:38:02Z |
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2016 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
BOMFIM, L. M. et al. Antitumour Activity of the Microencapsulation of Annona. Basic & Clinical Pharmacology Toxicology, v. 118, n. 3, p. 208-213, 2016. |
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https://www.arca.fiocruz.br/handle/icict/13240 |
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1742-7843 10.1111/bcpt.12488 |
| identifier_str_mv |
BOMFIM, L. M. et al. Antitumour Activity of the Microencapsulation of Annona. Basic & Clinical Pharmacology Toxicology, v. 118, n. 3, p. 208-213, 2016. 1742-7843 10.1111/bcpt.12488 |
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Wiley |
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Wiley |
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