Chemical constituents and anticancer effects of the essential oil from leaves of Xylopia laevigata
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20761 |
Resumo: | Bezerra, Daniel Pereira “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
| id |
CRUZ_19631c3f10b68439e6f1ea7635b6dcda |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/20761 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Quintans, Jullyana de Souza SiqueiraSoares, Bruno MarquesFerraz, Rosana Paula CruzOliveira, Allan Carlos Araújo deSilva, Thanany Brasil daMenezes, Leociley Rocha AlencarSampaio, Marília Fernanda ChavesPrata, Ana Paula do NascimentoMoraes, Manoel OPessoa, ClaudiaAntoniolli, Angelo RobertoCosta, Emmanoel VilaçaBezerra, Daniel Pereira2017-08-24T19:20:05Z2017-08-24T19:20:05Z2013QUINTANS, J. S. S. et al. Chemical Constituents and Anticancer Effects of the Essential Oil from Leaves of Xylopia laevigata. Planta Medica, v. 79, p. 123–130, 2013.0032-0943https://www.arca.fiocruz.br/handle/icict/2076110.1055/s-0032-1328091Bezerra, Daniel Pereira “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Capes (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnológico), and FAPITEC/SE (Fundação de Amparo à Pesquisa e à Inovação Tecnológicado Estado de Sergipe).Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrazilFederal University of Ceará. Department of Physiology and Pharmacology. Fortaleza, CE, BrasilFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Chemistry. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Chemistry. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Chemistry. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Biology. São Cristóvão, SE, BrazilFederal University of Ceará. Department of Physiology and Pharmacology. Fortaleza, CE, BrasilFederal University of Ceará. Department of Physiology and Pharmacology. Fortaleza, CE, BrasilFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Chemistry. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrazilXylopia laevigata, popularly known as "meiú" and "pindaíba", is a medicinal plant used in the folk medicine of the Brazilian Northeast for several purposes. The chemical constituents of the essential oil from leaves of X. laevigata, collected from wild plants growing at three different sites of the remaining Atlantic forest in Sergipe State (Brazilian Northeast), were analyzed by GC/FID and GC/MS. The effect of the essential oil samples was assessed on tumor cells in culture, as well on tumor growth in vivo. All samples of the essential oil were dominated by sesquiterpene constituents. A total of 44 compounds were identified and quantified. Although some small differences were observed in the chemical composition, the presence of γ-muurolene (0.60-17.99%), δ-cadinene (1.15-13.45%), germacrene B (3.22-7.31%), α-copaene (3.33-5.98%), germacrene D (9.09-60.44%), bicyclogermacrene (7.00-14.63%), and (E)-caryophyllene (5.43-7.98%) were verified as major constituents in all samples of the essential oil. In the in vitro cytotoxic study, the essential oil displayed cytotoxicity to all tumor cell lines tested, with the different samples displaying a similar profile; however, they were not hemolytic or genotoxic. In the in vivo antitumor study, tumor growth inhibition rates were 37.3-42.5%. The treatment with the essential oil did not significantly affect body weight, macroscopy of the organs, or blood leukocyte counts. In conclusion, the essential oil from the leaves of X. laevigata is chemically characterized by the presence of γ-muurolene, δ-cadinene, germacrene B, α-copaene, germacrene D, bicyclogermacrene, and (E)-caryophyllene as major constituents and possesses significant in vitro and in vivo anticancer potential.engGeorg Thieme VerlagXylopiaAnnonaceaeÓleosAntitumorXylopia laevigataAnnonaceaeEssential oilAntitumorChemical constituents and anticancer effects of the essential oil from leaves of Xylopia laevigatainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20761/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALQuintans J Chemical constituents and....pdfQuintans J Chemical constituents and....pdfapplication/pdf173149https://www.arca.fiocruz.br/bitstream/icict/20761/2/Quintans%20J%20Chemical%20constituents%20and....pdf056c0ac5477401287958c47cb6fc1a0bMD52TEXTQuintans J Chemical constituents and....pdf.txtQuintans J Chemical constituents and....pdf.txtExtracted texttext/plain46445https://www.arca.fiocruz.br/bitstream/icict/20761/3/Quintans%20J%20Chemical%20constituents%20and....pdf.txt80711ea7a41326d10c780ef3fb64f977MD53icict/207612023-03-15 14:34:02.993oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:02Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Chemical constituents and anticancer effects of the essential oil from leaves of Xylopia laevigata |
| title |
Chemical constituents and anticancer effects of the essential oil from leaves of Xylopia laevigata |
| spellingShingle |
Chemical constituents and anticancer effects of the essential oil from leaves of Xylopia laevigata Quintans, Jullyana de Souza Siqueira Xylopia Annonaceae Óleos Antitumor Xylopia laevigata Annonaceae Essential oil Antitumor |
| title_short |
Chemical constituents and anticancer effects of the essential oil from leaves of Xylopia laevigata |
| title_full |
Chemical constituents and anticancer effects of the essential oil from leaves of Xylopia laevigata |
| title_fullStr |
Chemical constituents and anticancer effects of the essential oil from leaves of Xylopia laevigata |
| title_full_unstemmed |
Chemical constituents and anticancer effects of the essential oil from leaves of Xylopia laevigata |
| title_sort |
Chemical constituents and anticancer effects of the essential oil from leaves of Xylopia laevigata |
| author |
Quintans, Jullyana de Souza Siqueira |
| author_facet |
Quintans, Jullyana de Souza Siqueira Soares, Bruno Marques Ferraz, Rosana Paula Cruz Oliveira, Allan Carlos Araújo de Silva, Thanany Brasil da Menezes, Leociley Rocha Alencar Sampaio, Marília Fernanda Chaves Prata, Ana Paula do Nascimento Moraes, Manoel O Pessoa, Claudia Antoniolli, Angelo Roberto Costa, Emmanoel Vilaça Bezerra, Daniel Pereira |
| author_role |
author |
| author2 |
Soares, Bruno Marques Ferraz, Rosana Paula Cruz Oliveira, Allan Carlos Araújo de Silva, Thanany Brasil da Menezes, Leociley Rocha Alencar Sampaio, Marília Fernanda Chaves Prata, Ana Paula do Nascimento Moraes, Manoel O Pessoa, Claudia Antoniolli, Angelo Roberto Costa, Emmanoel Vilaça Bezerra, Daniel Pereira |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Quintans, Jullyana de Souza Siqueira Soares, Bruno Marques Ferraz, Rosana Paula Cruz Oliveira, Allan Carlos Araújo de Silva, Thanany Brasil da Menezes, Leociley Rocha Alencar Sampaio, Marília Fernanda Chaves Prata, Ana Paula do Nascimento Moraes, Manoel O Pessoa, Claudia Antoniolli, Angelo Roberto Costa, Emmanoel Vilaça Bezerra, Daniel Pereira |
| dc.subject.other.pt_BR.fl_str_mv |
Xylopia Annonaceae Óleos Antitumor |
| topic |
Xylopia Annonaceae Óleos Antitumor Xylopia laevigata Annonaceae Essential oil Antitumor |
| dc.subject.en.pt_BR.fl_str_mv |
Xylopia laevigata Annonaceae Essential oil Antitumor |
| description |
Bezerra, Daniel Pereira “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
| publishDate |
2013 |
| dc.date.issued.fl_str_mv |
2013 |
| dc.date.accessioned.fl_str_mv |
2017-08-24T19:20:05Z |
| dc.date.available.fl_str_mv |
2017-08-24T19:20:05Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
QUINTANS, J. S. S. et al. Chemical Constituents and Anticancer Effects of the Essential Oil from Leaves of Xylopia laevigata. Planta Medica, v. 79, p. 123–130, 2013. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/20761 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0032-0943 |
| dc.identifier.doi.none.fl_str_mv |
10.1055/s-0032-1328091 |
| identifier_str_mv |
QUINTANS, J. S. S. et al. Chemical Constituents and Anticancer Effects of the Essential Oil from Leaves of Xylopia laevigata. Planta Medica, v. 79, p. 123–130, 2013. 0032-0943 10.1055/s-0032-1328091 |
| url |
https://www.arca.fiocruz.br/handle/icict/20761 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Georg Thieme Verlag |
| publisher.none.fl_str_mv |
Georg Thieme Verlag |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/20761/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/20761/2/Quintans%20J%20Chemical%20constituents%20and....pdf https://www.arca.fiocruz.br/bitstream/icict/20761/3/Quintans%20J%20Chemical%20constituents%20and....pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 056c0ac5477401287958c47cb6fc1a0b 80711ea7a41326d10c780ef3fb64f977 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813009167295709184 |