Analysis of antibody specificity against the third variable region of the envelope glycoprotein gp120 of HIV-1 in plasma from HIV-1-positive individuals residing in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1994 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15204 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil |
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Bongertz, VeraJansson, MFlodby, PMorgado, Mariza GonçalvesCastro Filho, Bernardo GalvãoWigzell, H2016-08-09T13:06:48Z2016-08-09T13:06:48Z1994BONGERTZ, V. et al. Analysis of antibody specificity against the third variable region of the envelope glycoprotein gp120 of HIV-1 in plasma from HIV-1-positive individuals residing in Brazil. Brazilian Journal of Medical Biological Researach, v. 27, n. 5, p. 1225-1236, 1994.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/15204engAssociação Brasileira de Divulgação CientíficaAnalysis of antibody specificity against the third variable region of the envelope glycoprotein gp120 of HIV-1 in plasma from HIV-1-positive individuals residing in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, BrasilKarolinska Institute. Department of Immunology. Stockholm, SwedenKarolinska Institute. Department of Immunology. Stockholm, SwedenFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilKarolinska Institute. Department of Immunology. Stockholm, Sweden1. Antibody specificity for the principal neutralization domain (PND) of the human immunodeficiency virus type 1 (HIV-1) was studied in plasma from 122 HIV-1-infected individuals residing in Brazil. 2. Using 8 overlapping sequential pentadecapeptides corresponding to the third variable region (V3) of 5 different HIV-1 isolates in an enzyme-linked immunosorbent assay (ELISA), a preferential recognition of the peptides with amino acid sequences corresponding to the HIV-1 isolates IIIB and MN (maximal reactivities of 60-70%) compared to the isolates SC, WMJ-2 or RF (maximal reactivities below 60%) was observed. 3. A difference was observed in the overall reactivity pattern to HIV-1 SC peptides of plasma collected from individuals residing in the Brazilian states of Rio de Janeiro and Bahia. However, a statistically significant increased recognition by Bahian plasma was only observed for the HIV-1 SC C55 peptide. 4. The mean CD4/CD8 ratio of the group of plasma with an isolate-restricted recognition of peptides (0.522 +/- 0.074) was significantly lower than that of the total group of plasma (1.00 +/- 0.18).HIV-1AIDSAntibodiesPNDY3 LoopBrazilHumansMolecular Sequence DataPeptide fragmentsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15204/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBongertz V Analysis of antibody.PDFBongertz V Analysis of antibody.PDFapplication/pdf5642463https://www.arca.fiocruz.br/bitstream/icict/15204/2/Bongertz%20V%20Analysis%20of%20antibody.PDF7543735f131bdbd37d5b5ec441e9e57bMD52TEXTBongertz V Analysis of antibody.PDF.txtBongertz V Analysis of antibody.PDF.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Analysis of antibody specificity against the third variable region of the envelope glycoprotein gp120 of HIV-1 in plasma from HIV-1-positive individuals residing in Brazil |
| title |
Analysis of antibody specificity against the third variable region of the envelope glycoprotein gp120 of HIV-1 in plasma from HIV-1-positive individuals residing in Brazil |
| spellingShingle |
Analysis of antibody specificity against the third variable region of the envelope glycoprotein gp120 of HIV-1 in plasma from HIV-1-positive individuals residing in Brazil Bongertz, Vera HIV-1 AIDS Antibodies PND Y3 Loop Brazil Humans Molecular Sequence Data Peptide fragments |
| title_short |
Analysis of antibody specificity against the third variable region of the envelope glycoprotein gp120 of HIV-1 in plasma from HIV-1-positive individuals residing in Brazil |
| title_full |
Analysis of antibody specificity against the third variable region of the envelope glycoprotein gp120 of HIV-1 in plasma from HIV-1-positive individuals residing in Brazil |
| title_fullStr |
Analysis of antibody specificity against the third variable region of the envelope glycoprotein gp120 of HIV-1 in plasma from HIV-1-positive individuals residing in Brazil |
| title_full_unstemmed |
Analysis of antibody specificity against the third variable region of the envelope glycoprotein gp120 of HIV-1 in plasma from HIV-1-positive individuals residing in Brazil |
| title_sort |
Analysis of antibody specificity against the third variable region of the envelope glycoprotein gp120 of HIV-1 in plasma from HIV-1-positive individuals residing in Brazil |
| author |
Bongertz, Vera |
| author_facet |
Bongertz, Vera Jansson, M Flodby, P Morgado, Mariza Gonçalves Castro Filho, Bernardo Galvão Wigzell, H |
| author_role |
author |
| author2 |
Jansson, M Flodby, P Morgado, Mariza Gonçalves Castro Filho, Bernardo Galvão Wigzell, H |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Bongertz, Vera Jansson, M Flodby, P Morgado, Mariza Gonçalves Castro Filho, Bernardo Galvão Wigzell, H |
| dc.subject.en.pt_BR.fl_str_mv |
HIV-1 AIDS Antibodies PND Y3 Loop Brazil Humans Molecular Sequence Data Peptide fragments |
| topic |
HIV-1 AIDS Antibodies PND Y3 Loop Brazil Humans Molecular Sequence Data Peptide fragments |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil |
| publishDate |
1994 |
| dc.date.issued.fl_str_mv |
1994 |
| dc.date.accessioned.fl_str_mv |
2016-08-09T13:06:48Z |
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2016-08-09T13:06:48Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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BONGERTZ, V. et al. Analysis of antibody specificity against the third variable region of the envelope glycoprotein gp120 of HIV-1 in plasma from HIV-1-positive individuals residing in Brazil. Brazilian Journal of Medical Biological Researach, v. 27, n. 5, p. 1225-1236, 1994. |
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https://www.arca.fiocruz.br/handle/icict/15204 |
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0100-879X |
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BONGERTZ, V. et al. Analysis of antibody specificity against the third variable region of the envelope glycoprotein gp120 of HIV-1 in plasma from HIV-1-positive individuals residing in Brazil. Brazilian Journal of Medical Biological Researach, v. 27, n. 5, p. 1225-1236, 1994. 0100-879X |
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Associação Brasileira de Divulgação Científica |
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Associação Brasileira de Divulgação Científica |
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