Oral mucoceles: a clinical, histopathological and immunohistochemical study.

Detalhes bibliográficos
Autor(a) principal: Conceição, Jamile Gomes
Data de Publicação: 2013
Outros Autores: Gurgel, Clarissa Araújo Silva, Ramos, Eduardo Antônio Gonçalves, Xavier, Flávia Caló De Aquino, Salesa, Caroline Brandi Schlaepfer, Cangussú, Maria Cristina Teixeira, Cury, Patrícia Ramos, Ramalho, Luciana Maria Pedreira, Santos, Jean Nunes dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8935
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Conceição, Jamile GomesGurgel, Clarissa Araújo SilvaRamos, Eduardo Antônio GonçalvesXavier, Flávia Caló De AquinoSalesa, Caroline Brandi SchlaepferCangussú, Maria Cristina TeixeiraCury, Patrícia RamosRamalho, Luciana Maria PedreiraSantos, Jean Nunes dos2014-11-21T14:05:53Z2014-11-21T14:05:53Z2013CONCEIÇÃO, J. G. et al. Oral mucoceles: a clinical, histopathological and immunohistochemical study. Acta Histochemica, v. 116, n. 1, p. 40-47, 2014.1618-0372https://www.arca.fiocruz.br/handle/icict/8935dx.doi.org/10.1016/j.acthis.2013.04.015engElsevierOral mucoceles: a clinical, histopathological and immunohistochemical study.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Department of Dental Public Health. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Department of Periodontics. Salvador, BA, BrasilFederal University of Bahia. School of Dentistry. Department of Stomatology. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, BrasiltThe aim of study was to evaluate the clinicopathological features of oral mucoceles and the immunohisto-chemical expression of cellular and extracellular matrix components in these lesions. One hundred casesof oral mucoceles were examined for clinicopathological features. The expression of mast cell tryptase,CD68, MMP-1 (matrix metalloproteinase-1), MMP-9 (matrix metalloproteinase-9) and CD34 was inves-tigated immunohistochemically in 32 cases. The lesions arose as nodules or blisters of variable color. Themean age was 23.2 years and a higher male frequency was observed. The most common locations werethe lower lip (92%), followed by the floor of the mouth (7%), and palate (1%). The lesion size ranged from0.4 to 3.0 cm. Unusual histopathological findings as superficial mucoceles (n = 16, 16%), pseudopapillaryprojections (n = 3, 3%), epithelioid histiocytes (n = 4, 4%), multinucleated giant cells (n = 1, 1%) and myx-oglobulosis (n = 9, 9%) were also seen. Mast cells and CD68-positive macrophages, MMP-1, MMP-9 andCD34-positive blood vessels were seen in all cases. A significant association was seen between mast cellsand MMP-1 (p = 0.03) and between macrophages and MMP-1 (p = 0.01). This study provided importantinsight into the demographic and histopathological occurrence of oral mucoceles. The tissue remodel-ing seen in these lesions mainly involved the migration and interaction of mast cells, macrophages andMMP-1.Oral mucocelesHistopathologyMyxoglobulosisImmunohistochemistryinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8935/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALConceicao JG Oral mucoceles...pdfConceicao JG Oral mucoceles...pdfapplication/pdf3926291https://www.arca.fiocruz.br/bitstream/icict/8935/2/Conceicao%20JG%20Oral%20mucoceles...pdf5131ed774a72acdb20b19373809720a6MD52TEXTConceicao JG Oral mucoceles...pdf.txtConceicao JG Oral mucoceles...pdf.txtExtracted texttext/plain40106https://www.arca.fiocruz.br/bitstream/icict/8935/3/Conceicao%20JG%20Oral%20mucoceles...pdf.txt50513162120e940bc262d098b053aa62MD53icict/89352023-03-15 14:33:01.396oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:01Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Oral mucoceles: a clinical, histopathological and immunohistochemical study.
title Oral mucoceles: a clinical, histopathological and immunohistochemical study.
spellingShingle Oral mucoceles: a clinical, histopathological and immunohistochemical study.
Conceição, Jamile Gomes
Oral mucoceles
Histopathology
Myxoglobulosis
Immunohistochemistry
title_short Oral mucoceles: a clinical, histopathological and immunohistochemical study.
title_full Oral mucoceles: a clinical, histopathological and immunohistochemical study.
title_fullStr Oral mucoceles: a clinical, histopathological and immunohistochemical study.
title_full_unstemmed Oral mucoceles: a clinical, histopathological and immunohistochemical study.
title_sort Oral mucoceles: a clinical, histopathological and immunohistochemical study.
author Conceição, Jamile Gomes
author_facet Conceição, Jamile Gomes
Gurgel, Clarissa Araújo Silva
Ramos, Eduardo Antônio Gonçalves
Xavier, Flávia Caló De Aquino
Salesa, Caroline Brandi Schlaepfer
Cangussú, Maria Cristina Teixeira
Cury, Patrícia Ramos
Ramalho, Luciana Maria Pedreira
Santos, Jean Nunes dos
author_role author
author2 Gurgel, Clarissa Araújo Silva
Ramos, Eduardo Antônio Gonçalves
Xavier, Flávia Caló De Aquino
Salesa, Caroline Brandi Schlaepfer
Cangussú, Maria Cristina Teixeira
Cury, Patrícia Ramos
Ramalho, Luciana Maria Pedreira
Santos, Jean Nunes dos
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Conceição, Jamile Gomes
Gurgel, Clarissa Araújo Silva
Ramos, Eduardo Antônio Gonçalves
Xavier, Flávia Caló De Aquino
Salesa, Caroline Brandi Schlaepfer
Cangussú, Maria Cristina Teixeira
Cury, Patrícia Ramos
Ramalho, Luciana Maria Pedreira
Santos, Jean Nunes dos
dc.subject.en.pt_BR.fl_str_mv Oral mucoceles
Histopathology
Myxoglobulosis
Immunohistochemistry
topic Oral mucoceles
Histopathology
Myxoglobulosis
Immunohistochemistry
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-11-21T14:05:53Z
dc.date.available.fl_str_mv 2014-11-21T14:05:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CONCEIÇÃO, J. G. et al. Oral mucoceles: a clinical, histopathological and immunohistochemical study. Acta Histochemica, v. 116, n. 1, p. 40-47, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8935
dc.identifier.issn.none.fl_str_mv 1618-0372
dc.identifier.doi.none.fl_str_mv dx.doi.org/10.1016/j.acthis.2013.04.015
identifier_str_mv CONCEIÇÃO, J. G. et al. Oral mucoceles: a clinical, histopathological and immunohistochemical study. Acta Histochemica, v. 116, n. 1, p. 40-47, 2014.
1618-0372
dx.doi.org/10.1016/j.acthis.2013.04.015
url https://www.arca.fiocruz.br/handle/icict/8935
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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