The Trypanocidal Activity of Naphthoquinones: A Review

Detalhes bibliográficos
Autor(a) principal: Pinto, Antônio Ventura
Data de Publicação: 2009
Outros Autores: Castro, Solange Lisboa de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30848
Resumo: Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Núcleo de Pesquisas em Produtos Naturais. Rio de Janeiro, RJ, Brasil.
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spelling Pinto, Antônio VenturaCastro, Solange Lisboa de2019-01-03T12:23:48Z2019-01-03T12:23:48Z2009PINTO, Antônio Ventura; CASTRO, Solange Lisboa de. The Trypanocidal Activity of Naphthoquinones: A Review. Molecules, v.14, p.4570-4590, 2009.1420-3049https://www.arca.fiocruz.br/handle/icict/308481420-3049engMDPIDoença de ChagasTrypanosoma cruziNaftoquinonasAtividade Tripanocidanaphthoquinonesβ-lapachoneChagas DiseaseTrypanosoma cruziTrypanocidal ActivityThe Trypanocidal Activity of Naphthoquinones: A Reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Núcleo de Pesquisas em Produtos Naturais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.Naphthoquinones are compounds present in several families of higher plants. Their molecular structures confer redox properties, and they are involved in multiple biological oxidative processes. In folk medicine, especially among Indian populations, plants containing naphthoquinones have been employed for the treatment of various diseases. The biological redox cycle of quinones can be initiated by one electron reduction leading to the formation of semiquinones, unstable intermediates that react rapidly with molecular oxygen, generating free radicals. Alternatively, the reduction by two electrons, mediated by DT-diphorase, leads to the formation of hydroquinone. Lapachol, α-lapachone and β-lapachone, which are isolated from the heartwood of trees of the Bignoniaceae family, are examples of bioactive naphthoquinones. In this review, we will discuss studies investigating the activity of these natural products and their derivatives in the context of the search for alternative drugs for Chagas disease, caused by Trypanosoma cruzi, a neglected illness that is endemic in Latin America.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30848/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALantoniopinto_solangecastro_IOC_2009.pdfantoniopinto_solangecastro_IOC_2009.pdfapplication/pdf613595https://www.arca.fiocruz.br/bitstream/icict/30848/2/antoniopinto_solangecastro_IOC_2009.pdfdbb943674aaf31b639ee9e639665c155MD52TEXTantoniopinto_solangecastro_IOC_2009.pdf.txtantoniopinto_solangecastro_IOC_2009.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The Trypanocidal Activity of Naphthoquinones: A Review
title The Trypanocidal Activity of Naphthoquinones: A Review
spellingShingle The Trypanocidal Activity of Naphthoquinones: A Review
Pinto, Antônio Ventura
Doença de Chagas
Trypanosoma cruzi
Naftoquinonas
Atividade Tripanocida
naphthoquinones
β-lapachone
Chagas Disease
Trypanosoma cruzi
Trypanocidal Activity
title_short The Trypanocidal Activity of Naphthoquinones: A Review
title_full The Trypanocidal Activity of Naphthoquinones: A Review
title_fullStr The Trypanocidal Activity of Naphthoquinones: A Review
title_full_unstemmed The Trypanocidal Activity of Naphthoquinones: A Review
title_sort The Trypanocidal Activity of Naphthoquinones: A Review
author Pinto, Antônio Ventura
author_facet Pinto, Antônio Ventura
Castro, Solange Lisboa de
author_role author
author2 Castro, Solange Lisboa de
author2_role author
dc.contributor.author.fl_str_mv Pinto, Antônio Ventura
Castro, Solange Lisboa de
dc.subject.other.pt_BR.fl_str_mv Doença de Chagas
Trypanosoma cruzi
Naftoquinonas
Atividade Tripanocida
topic Doença de Chagas
Trypanosoma cruzi
Naftoquinonas
Atividade Tripanocida
naphthoquinones
β-lapachone
Chagas Disease
Trypanosoma cruzi
Trypanocidal Activity
dc.subject.en.pt_BR.fl_str_mv naphthoquinones
β-lapachone
Chagas Disease
Trypanosoma cruzi
Trypanocidal Activity
description Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Núcleo de Pesquisas em Produtos Naturais. Rio de Janeiro, RJ, Brasil.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2019-01-03T12:23:48Z
dc.date.available.fl_str_mv 2019-01-03T12:23:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv PINTO, Antônio Ventura; CASTRO, Solange Lisboa de. The Trypanocidal Activity of Naphthoquinones: A Review. Molecules, v.14, p.4570-4590, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30848
dc.identifier.issn.pt_BR.fl_str_mv 1420-3049
dc.identifier.eissn.none.fl_str_mv 1420-3049
identifier_str_mv PINTO, Antônio Ventura; CASTRO, Solange Lisboa de. The Trypanocidal Activity of Naphthoquinones: A Review. Molecules, v.14, p.4570-4590, 2009.
1420-3049
url https://www.arca.fiocruz.br/handle/icict/30848
dc.language.iso.fl_str_mv eng
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