The Trypanocidal Activity of Naphthoquinones: A Review
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/30848 |
Resumo: | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Núcleo de Pesquisas em Produtos Naturais. Rio de Janeiro, RJ, Brasil. |
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Pinto, Antônio VenturaCastro, Solange Lisboa de2019-01-03T12:23:48Z2019-01-03T12:23:48Z2009PINTO, Antônio Ventura; CASTRO, Solange Lisboa de. The Trypanocidal Activity of Naphthoquinones: A Review. Molecules, v.14, p.4570-4590, 2009.1420-3049https://www.arca.fiocruz.br/handle/icict/308481420-3049engMDPIDoença de ChagasTrypanosoma cruziNaftoquinonasAtividade Tripanocidanaphthoquinonesβ-lapachoneChagas DiseaseTrypanosoma cruziTrypanocidal ActivityThe Trypanocidal Activity of Naphthoquinones: A Reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Núcleo de Pesquisas em Produtos Naturais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.Naphthoquinones are compounds present in several families of higher plants. Their molecular structures confer redox properties, and they are involved in multiple biological oxidative processes. In folk medicine, especially among Indian populations, plants containing naphthoquinones have been employed for the treatment of various diseases. The biological redox cycle of quinones can be initiated by one electron reduction leading to the formation of semiquinones, unstable intermediates that react rapidly with molecular oxygen, generating free radicals. Alternatively, the reduction by two electrons, mediated by DT-diphorase, leads to the formation of hydroquinone. Lapachol, α-lapachone and β-lapachone, which are isolated from the heartwood of trees of the Bignoniaceae family, are examples of bioactive naphthoquinones. In this review, we will discuss studies investigating the activity of these natural products and their derivatives in the context of the search for alternative drugs for Chagas disease, caused by Trypanosoma cruzi, a neglected illness that is endemic in Latin America.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30848/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALantoniopinto_solangecastro_IOC_2009.pdfantoniopinto_solangecastro_IOC_2009.pdfapplication/pdf613595https://www.arca.fiocruz.br/bitstream/icict/30848/2/antoniopinto_solangecastro_IOC_2009.pdfdbb943674aaf31b639ee9e639665c155MD52TEXTantoniopinto_solangecastro_IOC_2009.pdf.txtantoniopinto_solangecastro_IOC_2009.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
The Trypanocidal Activity of Naphthoquinones: A Review |
title |
The Trypanocidal Activity of Naphthoquinones: A Review |
spellingShingle |
The Trypanocidal Activity of Naphthoquinones: A Review Pinto, Antônio Ventura Doença de Chagas Trypanosoma cruzi Naftoquinonas Atividade Tripanocida naphthoquinones β-lapachone Chagas Disease Trypanosoma cruzi Trypanocidal Activity |
title_short |
The Trypanocidal Activity of Naphthoquinones: A Review |
title_full |
The Trypanocidal Activity of Naphthoquinones: A Review |
title_fullStr |
The Trypanocidal Activity of Naphthoquinones: A Review |
title_full_unstemmed |
The Trypanocidal Activity of Naphthoquinones: A Review |
title_sort |
The Trypanocidal Activity of Naphthoquinones: A Review |
author |
Pinto, Antônio Ventura |
author_facet |
Pinto, Antônio Ventura Castro, Solange Lisboa de |
author_role |
author |
author2 |
Castro, Solange Lisboa de |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Pinto, Antônio Ventura Castro, Solange Lisboa de |
dc.subject.other.pt_BR.fl_str_mv |
Doença de Chagas Trypanosoma cruzi Naftoquinonas Atividade Tripanocida |
topic |
Doença de Chagas Trypanosoma cruzi Naftoquinonas Atividade Tripanocida naphthoquinones β-lapachone Chagas Disease Trypanosoma cruzi Trypanocidal Activity |
dc.subject.en.pt_BR.fl_str_mv |
naphthoquinones β-lapachone Chagas Disease Trypanosoma cruzi Trypanocidal Activity |
description |
Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Núcleo de Pesquisas em Produtos Naturais. Rio de Janeiro, RJ, Brasil. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2019-01-03T12:23:48Z |
dc.date.available.fl_str_mv |
2019-01-03T12:23:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
PINTO, Antônio Ventura; CASTRO, Solange Lisboa de. The Trypanocidal Activity of Naphthoquinones: A Review. Molecules, v.14, p.4570-4590, 2009. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/30848 |
dc.identifier.issn.pt_BR.fl_str_mv |
1420-3049 |
dc.identifier.eissn.none.fl_str_mv |
1420-3049 |
identifier_str_mv |
PINTO, Antônio Ventura; CASTRO, Solange Lisboa de. The Trypanocidal Activity of Naphthoquinones: A Review. Molecules, v.14, p.4570-4590, 2009. 1420-3049 |
url |
https://www.arca.fiocruz.br/handle/icict/30848 |
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eng |
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MDPI |
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