Seroprevalence and molecular epidemiology of HTLV-1 isolates from HIV-1 co-infected women in Feira de Santana, Bahia, Brazil.

Detalhes bibliográficos
Autor(a) principal: Rego, Filipe Ferreira de Almeida
Data de Publicação: 2010
Outros Autores: Miranda, Aline Mota, Santos, Edson de Souza, Castro Filho, Bernardo Galvão, Alcantara, Luiz Carlos Júnior
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8906
Resumo: HTLV Center. Bahia School of Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, Brasil / HTLV Center/ Bahia School of Medicine and Public Health/Bahia Foundation for Science Development. Salvador, Bahia, Brasil
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spelling Rego, Filipe Ferreira de AlmeidaMiranda, Aline MotaSantos, Edson de SouzaCastro Filho, Bernardo GalvãoAlcantara, Luiz Carlos Júnior2014-11-18T18:41:00Z2014-11-18T18:41:00Z2010REGO, F. F. A. et al. Seroprevalence and molecular epidemiology of HTLV-1 isolates from HIV-1 co-infected women in Feira de Santana, Bahia, Brazil. AIDS Research and Human Retroviruses, v. 26, n. 12, p. 1333-1339, 2010.1931-8405https://www.arca.fiocruz.br/handle/icict/890610.1089/aid.2009.0298engMary Ann Liebert, IncSeroprevalence and molecular epidemiology of HTLV-1 isolates from HIV-1 co-infected women in Feira de Santana, Bahia, Brazil.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHTLV Center. Bahia School of Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, Brasil / HTLV Center/ Bahia School of Medicine and Public Health/Bahia Foundation for Science Development. Salvador, Bahia, BrasilHTLV Center. Bahia School of Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, Brasil / HTLV Center/ Bahia School of Medicine and Public Health/Bahia Foundation for Science Development. Salvador, Bahia, BrasilHTLV Center. Bahia School of Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, BrasilHTLV Center. Bahia School of Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, Brasil / HTLV Center/ Bahia School of Medicine and Public Health/Bahia Foundation for Science Development. Salvador, Bahia, BrasilHTLV Center. Bahia School of Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, Brasil / HTLV Center/ Bahia School of Medicine and Public Health/Bahia Foundation for Science Development. Salvador, Bahia, Brasil / National Cancer Institute. National Institutes of Health. Bethesda, MarylandHTLV–1/HIV-1 co-infection is associated with severe clinical manifestations, marked immunodeficiency, and opportunistic pathogenic infections, as well as risk behavior. Salvador, the capital of the State of Bahia, Brazil, has the highest HTLV-1 prevalence (1.74%) found in Brazil. Few studies exist which describe this co-infection found in Salvador and its surrounding areas, much less investigate how these viruses circulate or assess the relationship between them. To describe the epidemiological and molecular features of HTLV in HIV coinfected women. To investigate the prevalence of HTLV/HIV co-infection in surrounding areas, as well as the molecular epidemiology of HTLV, a cross sectional study was carried out involving 107 women infected with HIV-1 from the STD/HIV/AIDS Reference Center located in the neighboring City of Feira de Santana. Patient samples were submitted to ELISA, and HTLV infection was confirmed using Western Blot and Polymerase Chain Reaction (PCR). Phylogenetic analysis using Neighbor-Joining (NJ) and Maximum Likelihood (ML) was performed on HTLV LTR sequences in order to gain further insights about molecular epidemiology and the origins of this virus in Bahia. Four out of five reactive samples were confirmed to be infected with HTLV-1, and one with HTLV-2. The seroprevalence of HTLV among HIV-1 co-infected women was 4.7%. Phylogenetic analysis of the LTR region from four HTLV-1 sequences showed that all isolates were clustered into the main Latin American group within the Transcontinental subgroup of the Cosmopolitan subtype. The HTLV-2 sequence was classified as the HTLV-2c subtype. It was also observed that four HTLV/HIV-1 co-infected women exhibited risk behavior with two having parenteral exposure, while another two were sex workers. This article describes the characteristics of co-infected patients. This co-infection is known to be severe and further studies should be conducted to confirm the suggestion that HTLV-1 is spreading from Salvador to surrounding areasInfecções por HIV/complicaçõesInfecções por HTLV-I/epidemiologiaVírus 1 Linfotrópico T Humano/isolamento & purificaçãoAdultoBrasilAnálise por ConglomeradosEstudos TransversaisEnsaio de Imunoadsorção EnzimáticaFemininoGenótipoInfecções por HIV/virologiaHIV-1/isolamento & purificaçãoVírus 1 Linfotrópico T Humano/genéticaHumanosMeia-IdadeEpidemiologia MolecularDados de Sequência MolecularFilogeniaRNA Viral/genéticaAnálise de Sequência de DNAinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8906/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALRego FFA Seroprevalence.pdfRego FFA Seroprevalence.pdfapplication/pdf397297https://www.arca.fiocruz.br/bitstream/icict/8906/2/Rego%20FFA%20Seroprevalence.pdf8c2a0e5d43fba73bfd997f12e8d5a67eMD52TEXTRego FFA Seroprevalence.pdf.txtRego FFA Seroprevalence.pdf.txtExtracted texttext/plain26616https://www.arca.fiocruz.br/bitstream/icict/8906/3/Rego%20FFA%20Seroprevalence.pdf.txt29c9534e53d1bd727f643649ab0e1d69MD53icict/89062023-03-15 14:33:03.754oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:03Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Seroprevalence and molecular epidemiology of HTLV-1 isolates from HIV-1 co-infected women in Feira de Santana, Bahia, Brazil.
title Seroprevalence and molecular epidemiology of HTLV-1 isolates from HIV-1 co-infected women in Feira de Santana, Bahia, Brazil.
spellingShingle Seroprevalence and molecular epidemiology of HTLV-1 isolates from HIV-1 co-infected women in Feira de Santana, Bahia, Brazil.
Rego, Filipe Ferreira de Almeida
Infecções por HIV/complicações
Infecções por HTLV-I/epidemiologia
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Adulto
Brasil
Análise por Conglomerados
Estudos Transversais
Ensaio de Imunoadsorção Enzimática
Feminino
Genótipo
Infecções por HIV/virologia
HIV-1/isolamento & purificação
Vírus 1 Linfotrópico T Humano/genética
Humanos
Meia-Idade
Epidemiologia Molecular
Dados de Sequência Molecular
Filogenia
RNA Viral/genética
Análise de Sequência de DNA
title_short Seroprevalence and molecular epidemiology of HTLV-1 isolates from HIV-1 co-infected women in Feira de Santana, Bahia, Brazil.
title_full Seroprevalence and molecular epidemiology of HTLV-1 isolates from HIV-1 co-infected women in Feira de Santana, Bahia, Brazil.
title_fullStr Seroprevalence and molecular epidemiology of HTLV-1 isolates from HIV-1 co-infected women in Feira de Santana, Bahia, Brazil.
title_full_unstemmed Seroprevalence and molecular epidemiology of HTLV-1 isolates from HIV-1 co-infected women in Feira de Santana, Bahia, Brazil.
title_sort Seroprevalence and molecular epidemiology of HTLV-1 isolates from HIV-1 co-infected women in Feira de Santana, Bahia, Brazil.
author Rego, Filipe Ferreira de Almeida
author_facet Rego, Filipe Ferreira de Almeida
Miranda, Aline Mota
Santos, Edson de Souza
Castro Filho, Bernardo Galvão
Alcantara, Luiz Carlos Júnior
author_role author
author2 Miranda, Aline Mota
Santos, Edson de Souza
Castro Filho, Bernardo Galvão
Alcantara, Luiz Carlos Júnior
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Rego, Filipe Ferreira de Almeida
Miranda, Aline Mota
Santos, Edson de Souza
Castro Filho, Bernardo Galvão
Alcantara, Luiz Carlos Júnior
dc.subject.decs.pt_BR.fl_str_mv Infecções por HIV/complicações
Infecções por HTLV-I/epidemiologia
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Adulto
Brasil
Análise por Conglomerados
Estudos Transversais
Ensaio de Imunoadsorção Enzimática
Feminino
Genótipo
Infecções por HIV/virologia
HIV-1/isolamento & purificação
Vírus 1 Linfotrópico T Humano/genética
Humanos
Meia-Idade
Epidemiologia Molecular
Dados de Sequência Molecular
Filogenia
RNA Viral/genética
Análise de Sequência de DNA
topic Infecções por HIV/complicações
Infecções por HTLV-I/epidemiologia
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Adulto
Brasil
Análise por Conglomerados
Estudos Transversais
Ensaio de Imunoadsorção Enzimática
Feminino
Genótipo
Infecções por HIV/virologia
HIV-1/isolamento & purificação
Vírus 1 Linfotrópico T Humano/genética
Humanos
Meia-Idade
Epidemiologia Molecular
Dados de Sequência Molecular
Filogenia
RNA Viral/genética
Análise de Sequência de DNA
description HTLV Center. Bahia School of Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, Brasil / HTLV Center/ Bahia School of Medicine and Public Health/Bahia Foundation for Science Development. Salvador, Bahia, Brasil
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2014-11-18T18:41:00Z
dc.date.available.fl_str_mv 2014-11-18T18:41:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv REGO, F. F. A. et al. Seroprevalence and molecular epidemiology of HTLV-1 isolates from HIV-1 co-infected women in Feira de Santana, Bahia, Brazil. AIDS Research and Human Retroviruses, v. 26, n. 12, p. 1333-1339, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8906
dc.identifier.issn.none.fl_str_mv 1931-8405
dc.identifier.doi.none.fl_str_mv 10.1089/aid.2009.0298
identifier_str_mv REGO, F. F. A. et al. Seroprevalence and molecular epidemiology of HTLV-1 isolates from HIV-1 co-infected women in Feira de Santana, Bahia, Brazil. AIDS Research and Human Retroviruses, v. 26, n. 12, p. 1333-1339, 2010.
1931-8405
10.1089/aid.2009.0298
url https://www.arca.fiocruz.br/handle/icict/8906
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Mary Ann Liebert, Inc
publisher.none.fl_str_mv Mary Ann Liebert, Inc
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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