Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region.

Detalhes bibliográficos
Autor(a) principal: Kashima, Simone G
Data de Publicação: 2006
Outros Autores: Alcantara, Luiz Carlos Júnior, Takayanagui, Osvaldo Massaiti, Cunha, Marco Aurelio Valtas, Castro Filho, Bernardo Galvão, Oliveira, Maria Socorro Pombo de, Zago, Marco Antonio, Covas, Dimas Tadeu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8123
Resumo: Molecular Biology Laboratory. Regional Blood Center of Ribeirão Preto. Ribeirão Preto SP, Brasil
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spelling Kashima, Simone GAlcantara, Luiz Carlos JúniorTakayanagui, Osvaldo MassaitiCunha, Marco Aurelio ValtasCastro Filho, Bernardo GalvãoOliveira, Maria Socorro Pombo deZago, Marco AntonioCovas, Dimas Tadeu2014-08-04T18:08:19Z2014-08-04T18:08:19Z2006KASHIMA, S. et al. Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region. AIDS Reserach Human and Retroviruses, v. 22, n. 10, p. 953-599, 2006.0889-2229https://www.arca.fiocruz.br/handle/icict/8123engMary Ann Liebert, IncDistribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMolecular Biology Laboratory. Regional Blood Center of Ribeirão Preto. Ribeirão Preto SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilUniversidade de São Paulo. Departamento de Neurologia. Ribeirão Preto, SP, BrasilBioinformatic Laboratory. Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilInstituto Nacional do Cancer. Rio de Janeiro, RJ, BrasilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, BrasilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, BrasilWe report the molecular and epidemiological characterization of 128 human T cell lymphotropic virus type 1 (HTLV-1) isolates from Brazilian patients with different clinical manifestations of the infection. Thirty-two percent of the patients were asymptomatic, 44% had HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and 23% had adult T cell leukemia/lymphoma (ATLL). Phylogenetic analysis performed using part of the LTR region of the viral genome revealed that all Brazilian isolates belonged to the Cosmopolitan subtype, with the following distribution within the Transcontinental subgroup: 81.6% within the Latin American cluster and 15.8% outside the Latin American cluster. Two isolates belonged to the Japanese subgroup. Molecular analysis of the tax region showed a high nucleotide similarity ( 99%) with 41 prototype sequences, including the ATK-1 isolate. The mean number of nucleotide substitutions ranged from 1 to 8. Five specific nucleotide substitutions, C7401T, T7914C, C7920T, C7982T, and G8231A, were highly conserved among the Brazilian isolates (79.6%), with a frequency ranging from 81.6% to 100% in the sample group and from 18.4% to 24.1% in the prototypes used, suggesting the existence of a molecular signature. These changes were not correlated with a specific clinical status of the patients and could be a molecular characteristic of the HTLV-1 strains that circulate in Brazil.Genes pX/genéticaVírus 1 Linfotrópico T Humano/genéticaSequências Repetidas Terminais/genéticaAdolescenteAdultoIdosoBrasil/epidemiologiaFemininoInfecções por HTLV-I/epidemiologiaHumanosMasculinoMeia-IdadeEpidemiologia MolecularDados de Sequência Molecularinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALKashima S Distribution....pdfKashima S Distribution....pdfapplication/pdf351118https://www.arca.fiocruz.br/bitstream/icict/8123/1/Kashima%20S%20Distribution....pdf8590e99f92b1e456d3187fb524e14fdfMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8123/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTKashima S Distribution....pdf.txtKashima S Distribution....pdf.txtExtracted texttext/plain28214https://www.arca.fiocruz.br/bitstream/icict/8123/3/Kashima%20S%20Distribution....pdf.txt00b2ef8ac9586958304521a84862fabfMD53icict/81232023-03-15 14:33:22.424oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region.
title Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region.
spellingShingle Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region.
Kashima, Simone G
Genes pX/genética
Vírus 1 Linfotrópico T Humano/genética
Sequências Repetidas Terminais/genética
Adolescente
Adulto
Idoso
Brasil/epidemiologia
Feminino
Infecções por HTLV-I/epidemiologia
Humanos
Masculino
Meia-Idade
Epidemiologia Molecular
Dados de Sequência Molecular
title_short Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region.
title_full Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region.
title_fullStr Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region.
title_full_unstemmed Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region.
title_sort Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region.
author Kashima, Simone G
author_facet Kashima, Simone G
Alcantara, Luiz Carlos Júnior
Takayanagui, Osvaldo Massaiti
Cunha, Marco Aurelio Valtas
Castro Filho, Bernardo Galvão
Oliveira, Maria Socorro Pombo de
Zago, Marco Antonio
Covas, Dimas Tadeu
author_role author
author2 Alcantara, Luiz Carlos Júnior
Takayanagui, Osvaldo Massaiti
Cunha, Marco Aurelio Valtas
Castro Filho, Bernardo Galvão
Oliveira, Maria Socorro Pombo de
Zago, Marco Antonio
Covas, Dimas Tadeu
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kashima, Simone G
Alcantara, Luiz Carlos Júnior
Takayanagui, Osvaldo Massaiti
Cunha, Marco Aurelio Valtas
Castro Filho, Bernardo Galvão
Oliveira, Maria Socorro Pombo de
Zago, Marco Antonio
Covas, Dimas Tadeu
dc.subject.decs.pt_BR.fl_str_mv Genes pX/genética
Vírus 1 Linfotrópico T Humano/genética
Sequências Repetidas Terminais/genética
Adolescente
Adulto
Idoso
Brasil/epidemiologia
Feminino
Infecções por HTLV-I/epidemiologia
Humanos
Masculino
Meia-Idade
Epidemiologia Molecular
Dados de Sequência Molecular
topic Genes pX/genética
Vírus 1 Linfotrópico T Humano/genética
Sequências Repetidas Terminais/genética
Adolescente
Adulto
Idoso
Brasil/epidemiologia
Feminino
Infecções por HTLV-I/epidemiologia
Humanos
Masculino
Meia-Idade
Epidemiologia Molecular
Dados de Sequência Molecular
description Molecular Biology Laboratory. Regional Blood Center of Ribeirão Preto. Ribeirão Preto SP, Brasil
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2014-08-04T18:08:19Z
dc.date.available.fl_str_mv 2014-08-04T18:08:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv KASHIMA, S. et al. Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region. AIDS Reserach Human and Retroviruses, v. 22, n. 10, p. 953-599, 2006.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8123
dc.identifier.issn.none.fl_str_mv 0889-2229
identifier_str_mv KASHIMA, S. et al. Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region. AIDS Reserach Human and Retroviruses, v. 22, n. 10, p. 953-599, 2006.
0889-2229
url https://www.arca.fiocruz.br/handle/icict/8123
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Mary Ann Liebert, Inc
publisher.none.fl_str_mv Mary Ann Liebert, Inc
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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