Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil.

Detalhes bibliográficos
Autor(a) principal: Machado Junior, Almério
Data de Publicação: 2009
Outros Autores: Finkmoore, Brook, Emodi, Krisztina, Takenami, Iukary Oliveira, Bessa, Theolis Costa Barbosa, Tavares, Maria Brandão, Reis, Mitermayer Galvão dos, Arruda, Sérgio Marcos, Riley, Lee Woodland
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7518
Resumo: Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Especializado Octávio Mangabeira. Salvador, BA, Brasil
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spelling Machado Junior, AlmérioFinkmoore, BrookEmodi, KrisztinaTakenami, Iukary OliveiraBessa, Theolis Costa BarbosaTavares, Maria BrandãoReis, Mitermayer Galvão dosArruda, Sérgio MarcosRiley, Lee Woodland2014-04-14T17:35:21Z2014-04-14T17:35:21Z2009MACHADO JUNIOR, A. et al. Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil.The International Journal of Tuberculosis and Lung Disease, v. 13, n. 6, p. 719-725, 2009.1027-3719https://www.arca.fiocruz.br/handle/icict/7518engThe UnionRisk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Especializado Octávio Mangabeira. Salvador, BA, BrasilUniversity of California. Berkeley School of Public Health. California, USAUniversity of California. Berkeley School of Public Health. California, USAEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública, Centro de Pesquisas Gonçalo Moniz, Salvador, BA, BraSilUniversity of California. Berkeley School of Public Health. California, USABACKGROUND: Although treatment of latent tuberculosis infection (LTBI) is an essential component of tuberculosis (TB) control in countries such as the United States, it is not widely practiced in most TB-endemic countries. OBJECTIVE: To examine the practice of and adherence to LTBI treatment in a high-risk population in Brazil. DESIGN: We followed household contacts (HHCs) of patients hospitalized with pulmonary TB in Salvador, Brazil, for 6 months after they initiated LTBI treatment with isoniazid (INH). HHCs were asked to return to the hospital once a month for 6 months for follow-up visits and INH refills. RESULTS: Of 101 HHCs who initiated LTBI treatment, 54 (53.5%) completed the 6-month regimen. The risk of treatment non-completion was significantly higher in HHCs who reported side effects to INH (RR 2.69, 95%CI 1.3-5.8, P = 0.01), and in those who had to take two buses for a one-way trip to the hospital (RR 1.8, 95%CI 1.01-3.3, P = 0.04). Of the 101 HHCs, 29 (28.7%) did not return for any follow-up visits; these HHCs were significantly more likely to have a 2-bus commute to the hospital compared to HHCs who completed treatment (OR 20.69, 95%CI 2.1-208.4, P = 0.01). CONCLUSION: Nearly 50% of HHCs at high risk for developing TB completed a 6-month course of LTBI treatment. Completion of LTBI treatment was most affected by medication intolerance and commuting difficulties for follow-up visits.Latent tuberculosis infectionIsoniazidAdherencehoUsehold contactsAntituberculosos/uso terapêuticoIsoniazida/uso terapêuticoAdesão à MedicaçãoTuberculose Pulmonar/quimioterapiaAdolescenteAdultoBrasilCriançaPré-EscolarFemininoSeguimentosHumanosLactenteRecém-NascidoMasculinoEstudos ProspectivosFatores de RiscoTransportesAdulto Joveminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMachado A JR Risk factors for....pdfMachado A JR Risk factors for....pdfapplication/pdf269329https://www.arca.fiocruz.br/bitstream/icict/7518/1/Machado%20A%20JR%20Risk%20factors%20for....pdfef198bfc8b3d03455670901233ce8577MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7518/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTMachado A JR Risk factors for....pdf.txtMachado A JR Risk factors for....pdf.txtExtracted texttext/plain32562https://www.arca.fiocruz.br/bitstream/icict/7518/5/Machado%20A%20JR%20Risk%20factors%20for....pdf.txtb7b5ed66c6c50383d27e4323a1871452MD55THUMBNAILMachado A JR Risk factors for....pdf.jpgMachado A JR Risk factors for....pdf.jpgGenerated Thumbnailimage/jpeg2330https://www.arca.fiocruz.br/bitstream/icict/7518/4/Machado%20A%20JR%20Risk%20factors%20for....pdf.jpg26b050a96f3664d63765995502aa2a57MD54icict/75182023-03-15 14:33:19.594oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:19Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil.
title Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil.
spellingShingle Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil.
Machado Junior, Almério
Latent tuberculosis infection
Isoniazid
Adherence
hoUsehold contacts
Antituberculosos/uso terapêutico
Isoniazida/uso terapêutico
Adesão à Medicação
Tuberculose Pulmonar/quimioterapia
Adolescente
Adulto
Brasil
Criança
Pré-Escolar
Feminino
Seguimentos
Humanos
Lactente
Recém-Nascido
Masculino
Estudos Prospectivos
Fatores de Risco
Transportes
Adulto Jovem
title_short Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil.
title_full Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil.
title_fullStr Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil.
title_full_unstemmed Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil.
title_sort Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil.
author Machado Junior, Almério
author_facet Machado Junior, Almério
Finkmoore, Brook
Emodi, Krisztina
Takenami, Iukary Oliveira
Bessa, Theolis Costa Barbosa
Tavares, Maria Brandão
Reis, Mitermayer Galvão dos
Arruda, Sérgio Marcos
Riley, Lee Woodland
author_role author
author2 Finkmoore, Brook
Emodi, Krisztina
Takenami, Iukary Oliveira
Bessa, Theolis Costa Barbosa
Tavares, Maria Brandão
Reis, Mitermayer Galvão dos
Arruda, Sérgio Marcos
Riley, Lee Woodland
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Machado Junior, Almério
Finkmoore, Brook
Emodi, Krisztina
Takenami, Iukary Oliveira
Bessa, Theolis Costa Barbosa
Tavares, Maria Brandão
Reis, Mitermayer Galvão dos
Arruda, Sérgio Marcos
Riley, Lee Woodland
dc.subject.en.pt_BR.fl_str_mv Latent tuberculosis infection
Isoniazid
Adherence
hoUsehold contacts
topic Latent tuberculosis infection
Isoniazid
Adherence
hoUsehold contacts
Antituberculosos/uso terapêutico
Isoniazida/uso terapêutico
Adesão à Medicação
Tuberculose Pulmonar/quimioterapia
Adolescente
Adulto
Brasil
Criança
Pré-Escolar
Feminino
Seguimentos
Humanos
Lactente
Recém-Nascido
Masculino
Estudos Prospectivos
Fatores de Risco
Transportes
Adulto Jovem
dc.subject.decs.pt_BR.fl_str_mv Antituberculosos/uso terapêutico
Isoniazida/uso terapêutico
Adesão à Medicação
Tuberculose Pulmonar/quimioterapia
Adolescente
Adulto
Brasil
Criança
Pré-Escolar
Feminino
Seguimentos
Humanos
Lactente
Recém-Nascido
Masculino
Estudos Prospectivos
Fatores de Risco
Transportes
Adulto Jovem
description Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Especializado Octávio Mangabeira. Salvador, BA, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2014-04-14T17:35:21Z
dc.date.available.fl_str_mv 2014-04-14T17:35:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MACHADO JUNIOR, A. et al. Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil.The International Journal of Tuberculosis and Lung Disease, v. 13, n. 6, p. 719-725, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7518
dc.identifier.issn.none.fl_str_mv 1027-3719
identifier_str_mv MACHADO JUNIOR, A. et al. Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil.The International Journal of Tuberculosis and Lung Disease, v. 13, n. 6, p. 719-725, 2009.
1027-3719
url https://www.arca.fiocruz.br/handle/icict/7518
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv The Union
publisher.none.fl_str_mv The Union
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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