Hormone levels are associated with clinical markers and cytokine levels in human localized cutaneous leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Baccan, Gyselle Chrystina
Data de Publicação: 2011
Outros Autores: Oliveira, Fabiano, Sousa, Adenilma Duranes, Cerqueira, Natali Alexandrino, Costa, Jackson Mauricio Lopes, Barral Netto, Manoel, Barral, Aldina Maria Prado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1016/j.bbi.2010.12.009
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7354
Resumo: Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biofunção. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
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spelling Baccan, Gyselle ChrystinaOliveira, FabianoSousa, Adenilma DuranesCerqueira, Natali AlexandrinoCosta, Jackson Mauricio LopesBarral Netto, ManoelBarral, Aldina Maria Prado2014-02-25T18:45:25Z2014-02-25T18:45:25Z2011BACCAN, G. C. et al. Hormone levels are associated with clinical markers and cytokine levels in human localized cutaneous leishmaniasis. Brain, Behavior and Immunity, v. 25, n. 3, p. 548-554, 2011.1090-2139https://www.arca.fiocruz.br/handle/icict/735410.1016/j.bbi.2010.12.009engElsevier Inc. AllHormone levels are associated with clinical markers and cytokine levels in human localized cutaneous leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biofunção. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biofunção. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilLeishmaniasis is a serious health problem in several parts of the world, and localized cutaneous leishmaniasis (LCL) is the most frequent presentation of the tegumentary form of this disease cluster. Clinical presentations of leishmaniasis are influenced by both parasite and host factors, with emphasis on the host immune response. Alterations in plasma hormone levels have been described in many infections, and changes in hormone levels could be related to an imbalanced cytokine profile. In the present work, we evaluated a group of patients with LCL to determine changes in plasma hormone levels (cortisol, DHEA-S, estradiol, prolactin and testosterone) and their association with clinical markers of disease (lesion size, dose used to reach cure and time to cure) and with cytokines produced by PBMC stimulated by SLA (IFN-γ, IL-10 and TNF-α). Individuals with LCL exhibited lower plasma levels of DHEA-S, prolactin and testosterone compared with sex-matched controls, whereas levels of cortisol and estradiol were similar between patients and controls. Plasma levels of cortisol, estradiol or prolactin positively correlated with at least one clinical parameter. Cortisol and prolactin levels exhibited a negative correlation with levels of IFN-γ, whereas no correlation was observed with IL-10 or TNF-α levels. A decrease in DHEA-S levels was observed in male LCL patients when compared to male healthy controls. No other differences between the sexes were observed. Our results indicate a role for neuroendocrine regulation that restricts Th1 responses in human LCL. It is possible that, although impairing parasite killing, such neuroimmunomodulation may contribute to limiting tissue damage.Citocinas/sangueHormônios Esteroides Gonadais/sangueHidrocortisona/sangueLeishmaniose Cutânea/sangueProlactina/sangueAdultoEnsaio de Imunoadsorção EnzimáticaFemininoHumanosMasculinoMeia-Idadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBaccan G. C Hormone levels are....pdfBaccan G. 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dc.title.pt_BR.fl_str_mv Hormone levels are associated with clinical markers and cytokine levels in human localized cutaneous leishmaniasis
title Hormone levels are associated with clinical markers and cytokine levels in human localized cutaneous leishmaniasis
spellingShingle Hormone levels are associated with clinical markers and cytokine levels in human localized cutaneous leishmaniasis
Baccan, Gyselle Chrystina
Citocinas/sangue
Hormônios Esteroides Gonadais/sangue
Hidrocortisona/sangue
Leishmaniose Cutânea/sangue
Prolactina/sangue
Adulto
Ensaio de Imunoadsorção Enzimática
Feminino
Humanos
Masculino
Meia-Idade
title_short Hormone levels are associated with clinical markers and cytokine levels in human localized cutaneous leishmaniasis
title_full Hormone levels are associated with clinical markers and cytokine levels in human localized cutaneous leishmaniasis
title_fullStr Hormone levels are associated with clinical markers and cytokine levels in human localized cutaneous leishmaniasis
title_full_unstemmed Hormone levels are associated with clinical markers and cytokine levels in human localized cutaneous leishmaniasis
title_sort Hormone levels are associated with clinical markers and cytokine levels in human localized cutaneous leishmaniasis
author Baccan, Gyselle Chrystina
author_facet Baccan, Gyselle Chrystina
Oliveira, Fabiano
Sousa, Adenilma Duranes
Cerqueira, Natali Alexandrino
Costa, Jackson Mauricio Lopes
Barral Netto, Manoel
Barral, Aldina Maria Prado
author_role author
author2 Oliveira, Fabiano
Sousa, Adenilma Duranes
Cerqueira, Natali Alexandrino
Costa, Jackson Mauricio Lopes
Barral Netto, Manoel
Barral, Aldina Maria Prado
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Baccan, Gyselle Chrystina
Oliveira, Fabiano
Sousa, Adenilma Duranes
Cerqueira, Natali Alexandrino
Costa, Jackson Mauricio Lopes
Barral Netto, Manoel
Barral, Aldina Maria Prado
dc.subject.decs.pt_BR.fl_str_mv Citocinas/sangue
Hormônios Esteroides Gonadais/sangue
Hidrocortisona/sangue
Leishmaniose Cutânea/sangue
Prolactina/sangue
Adulto
Ensaio de Imunoadsorção Enzimática
Feminino
Humanos
Masculino
Meia-Idade
topic Citocinas/sangue
Hormônios Esteroides Gonadais/sangue
Hidrocortisona/sangue
Leishmaniose Cutânea/sangue
Prolactina/sangue
Adulto
Ensaio de Imunoadsorção Enzimática
Feminino
Humanos
Masculino
Meia-Idade
description Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Biofunção. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-02-25T18:45:25Z
dc.date.available.fl_str_mv 2014-02-25T18:45:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BACCAN, G. C. et al. Hormone levels are associated with clinical markers and cytokine levels in human localized cutaneous leishmaniasis. Brain, Behavior and Immunity, v. 25, n. 3, p. 548-554, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7354
dc.identifier.issn.none.fl_str_mv 1090-2139
dc.identifier.doi.none.fl_str_mv 10.1016/j.bbi.2010.12.009
identifier_str_mv BACCAN, G. C. et al. Hormone levels are associated with clinical markers and cytokine levels in human localized cutaneous leishmaniasis. Brain, Behavior and Immunity, v. 25, n. 3, p. 548-554, 2011.
1090-2139
10.1016/j.bbi.2010.12.009
url https://www.arca.fiocruz.br/handle/icict/7354
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier Inc. All
publisher.none.fl_str_mv Elsevier Inc. All
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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