Presence and clinical impact of human herpesvirus‐6 infection in patients with moderate to critical coronavirus disease‐19

Detalhes bibliográficos
Autor(a) principal: Lino, Katia
Data de Publicação: 2021
Outros Autores: Alves, Lilian S., Raposo, Jessica V., Medeiros, Thalia, Souza, Cintia F., Silva, Andrea A. da, Paula, Vanessa Salete de, Almeida, Jorge R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50910
Resumo: Universidade Federal Fluminense. Fauldade de Medicina. Laboratório Multiusuário de Apoio à Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil / Universidade Federal Fluminense. Faculdade de Medicina. Programa de Pós-Graduação em Ciências Médicas. Niterói, RJ, Brasil.
id CRUZ_1828c1922092d6af3e69b9c818b8d481
oai_identifier_str oai:www.arca.fiocruz.br:icict/50910
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Lino, KatiaAlves, Lilian S.Raposo, Jessica V.Medeiros, ThaliaSouza, Cintia F.Silva, Andrea A. daPaula, Vanessa Salete deAlmeida, Jorge R.2022-01-26T18:11:41Z2022-01-26T18:11:41Z2021LINO, Katia et al. Presence and clinical impact of human herpesvirus‐6 infection in patients with moderate to critical coronavirus disease‐19. Journal of Medical Virology, p. 1-5, Oct. 2021.1096-9071https://www.arca.fiocruz.br/handle/icict/5091010.1002/jmv.27392engWileyCOVID-19HHV‐6Herpesvírus-6Infecção por herpes vírus-6 humanoCOVID-19Herpesvirus‐6HHV‐6human herpesvirus‐6 infectionPresence and clinical impact of human herpesvirus‐6 infection in patients with moderate to critical coronavirus disease‐19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Fluminense. Fauldade de Medicina. Laboratório Multiusuário de Apoio à Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil / Universidade Federal Fluminense. Faculdade de Medicina. Programa de Pós-Graduação em Ciências Médicas. Niterói, RJ, Brasil.Universidade Federal Fluminense. Fauldade de Medicina. Laboratório Multiusuário de Apoio à Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasi / Universidade Federal Fluminense. Fauldade de Medicina. Programa de Pós-Graduação em Patologia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Fauldade de Medicina. Laboratório Multiusuário de Apoio à Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil / Universidade Federal Fluminense. Fauldade de Medicina. Programa de Pós-Graduação em Patologia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Fauldade de Medicina. Laboratório Multiusuário de Apoio à Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil / Universidade Federal Fluminense. Faculdade de Medicina. Programa de Pós-Graduação em Ciências Médicas. Niterói, RJ, Brasil.Universidade Federal Fluminense. Fauldade de Medicina. Laboratório Multiusuário de Apoio à Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil / Universidade Federal Fluminense. Faculdade de Medicina. Departamento de Clínica Médica. Niterói, RJ, Brasil / Universidade Federal Fluminense. Fauldade de Medicina. Programa de Pós-Graduação em Patologia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Faculdade de Medicina. Departamento de Clínica Médica. Niterói, RJ, Brasil / Universidade Federal Fluminense. Faculdade de Medicina. Programa de Pós-Graduação em Ciências Médicas. Niterói, RJ, Brasil.Human herpesvirus‐6 (HHV‐6) may cause serious diseases in immunocompromised individuals. SARS‐CoV‐2/HHV‐6 coinfection has been emphasized in previous works, mostly case reports, small series, or epidemiological studies, but few are known about its real clinical outcomes. Here we present a real‐world pilot study aiming to understand the frequency and the clinical impact of HHV‐6 coinfection in moderate to critically ill patients hospitalized due to COVID‐19. SARS‐CoV‐2 and HHV‐6 were evaluated in nasopharyngeal samples at the hospital admission of suspected COVID‐19 patients. From 173 consecutive cases, 60 were SARS‐CoV‐2 positive and 13/60 (21.7%) were HHV‐6 positive after identified as the HHV‐6B species by a Sanger sequencing. The SARS‐CoV‐2+/HHV‐6+ group was younger but not significant for cardiovascular diseases, diabetes, obesity, and cancer, but significant among therapeutic immunosuppressed patients (as systemic lupus erythematosus and kidney transplant patients). In the medical records, only sparse data on cutaneous or neurological manifestations were found. Biochemical and hematological data showed only a trend towards hyperferritinemic status and lymphopenia. In conclusion, despite the impressive high frequency of HHV‐6 coinfection in SARS‐CoV‐2 positive cases, it did not impact general mortality. We suggest larger future prospective studies to better elucidate the influence of HHV‐6 reactivation in cases of COVID‐19, designed to specific assessment of clinical outcomes and viral reactivation mechanisms.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/50910/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVanessaS_Paula_etal_IOC_2021.pdfVanessaS_Paula_etal_IOC_2021.pdfapplication/pdf585066https://www.arca.fiocruz.br/bitstream/icict/50910/2/VanessaS_Paula_etal_IOC_2021.pdfbe8f67bcf423dd6287b9d7ffcea3352fMD52icict/509102022-07-10 00:02:15.115oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-07-10T03:02:15Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Presence and clinical impact of human herpesvirus‐6 infection in patients with moderate to critical coronavirus disease‐19
title Presence and clinical impact of human herpesvirus‐6 infection in patients with moderate to critical coronavirus disease‐19
spellingShingle Presence and clinical impact of human herpesvirus‐6 infection in patients with moderate to critical coronavirus disease‐19
Lino, Katia
COVID-19
HHV‐6
Herpesvírus-6
Infecção por herpes vírus-6 humano
COVID-19
Herpesvirus‐6
HHV‐6
human herpesvirus‐6 infection
title_short Presence and clinical impact of human herpesvirus‐6 infection in patients with moderate to critical coronavirus disease‐19
title_full Presence and clinical impact of human herpesvirus‐6 infection in patients with moderate to critical coronavirus disease‐19
title_fullStr Presence and clinical impact of human herpesvirus‐6 infection in patients with moderate to critical coronavirus disease‐19
title_full_unstemmed Presence and clinical impact of human herpesvirus‐6 infection in patients with moderate to critical coronavirus disease‐19
title_sort Presence and clinical impact of human herpesvirus‐6 infection in patients with moderate to critical coronavirus disease‐19
author Lino, Katia
author_facet Lino, Katia
Alves, Lilian S.
Raposo, Jessica V.
Medeiros, Thalia
Souza, Cintia F.
Silva, Andrea A. da
Paula, Vanessa Salete de
Almeida, Jorge R.
author_role author
author2 Alves, Lilian S.
Raposo, Jessica V.
Medeiros, Thalia
Souza, Cintia F.
Silva, Andrea A. da
Paula, Vanessa Salete de
Almeida, Jorge R.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lino, Katia
Alves, Lilian S.
Raposo, Jessica V.
Medeiros, Thalia
Souza, Cintia F.
Silva, Andrea A. da
Paula, Vanessa Salete de
Almeida, Jorge R.
dc.subject.other.pt_BR.fl_str_mv COVID-19
HHV‐6
Herpesvírus-6
Infecção por herpes vírus-6 humano
topic COVID-19
HHV‐6
Herpesvírus-6
Infecção por herpes vírus-6 humano
COVID-19
Herpesvirus‐6
HHV‐6
human herpesvirus‐6 infection
dc.subject.en.pt_BR.fl_str_mv COVID-19
Herpesvirus‐6
HHV‐6
human herpesvirus‐6 infection
description Universidade Federal Fluminense. Fauldade de Medicina. Laboratório Multiusuário de Apoio à Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil / Universidade Federal Fluminense. Faculdade de Medicina. Programa de Pós-Graduação em Ciências Médicas. Niterói, RJ, Brasil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-01-26T18:11:41Z
dc.date.available.fl_str_mv 2022-01-26T18:11:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LINO, Katia et al. Presence and clinical impact of human herpesvirus‐6 infection in patients with moderate to critical coronavirus disease‐19. Journal of Medical Virology, p. 1-5, Oct. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50910
dc.identifier.issn.pt_BR.fl_str_mv 1096-9071
dc.identifier.doi.none.fl_str_mv 10.1002/jmv.27392
identifier_str_mv LINO, Katia et al. Presence and clinical impact of human herpesvirus‐6 infection in patients with moderate to critical coronavirus disease‐19. Journal of Medical Virology, p. 1-5, Oct. 2021.
1096-9071
10.1002/jmv.27392
url https://www.arca.fiocruz.br/handle/icict/50910
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50910/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50910/2/VanessaS_Paula_etal_IOC_2021.pdf
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
be8f67bcf423dd6287b9d7ffcea3352f
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009117190553600

Registros relacionados