Guillain-Barré syndrome and Miller Fisher syndrome in association with an arboviral outbreak: a Brazilian case seriesw

Detalhes bibliográficos
Autor(a) principal: Rosário, Mateus Santana do
Data de Publicação: 2022
Outros Autores: Jesus, Pedro Antônio Pereira de, Farias, Daniel Santana, Novaes, Marco Antônio Caires, Francisco, Marcos Vinicius Lima Oliveira, Santos, Cleiton Silva, Moura, Daniel, Lima, Fernanda Washington de M., Alcantara, Luiz Carlos Junior, Siqueira, Isadora Cristina de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57282
Resumo: Ministério da Ciência, Tecnologia, Inovação (MCTI). Financiadora de Estudos e Projetos (FINEP). Fundo Nacional para o Desenvolvimento da Ciência e Tecnologia (FNDCT). Programa de Excelência em Pesquisa (PROEP). Instituto Gonçalo Moniz (IGM-Fiocruz)
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spelling Rosário, Mateus Santana doJesus, Pedro Antônio Pereira deFarias, Daniel SantanaNovaes, Marco Antônio CairesFrancisco, Marcos Vinicius Lima OliveiraSantos, Cleiton SilvaMoura, DanielLima, Fernanda Washington de M.Alcantara, Luiz Carlos JuniorSiqueira, Isadora Cristina de2023-03-08T16:36:19Z2023-03-08T16:36:19Z2022ROSÁRIO, Mateus Santana do et al. Guillain-Barré syndrome and Miller Fisher Syndrome in association with an arboviral outbreak: a Brazilian case series. Frontiers in Medicine, v. 9, p. 1-7, 2022.2296-858Xhttps://www.arca.fiocruz.br/handle/icict/5728210.3389/fmed.2022.911175Ministério da Ciência, Tecnologia, Inovação (MCTI). Financiadora de Estudos e Projetos (FINEP). Fundo Nacional para o Desenvolvimento da Ciência e Tecnologia (FNDCT). Programa de Excelência em Pesquisa (PROEP). Instituto Gonçalo Moniz (IGM-Fiocruz)Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Secretaria Estadual da Saúde da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil / Santa Casa de Misericórdia da Bahia. Hospital Santa Izabel. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Secretaria Estadual da Saúde da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Secretaria Estadual da Saúde da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil.Fundação Monte Tabor. Hospital São Rafael, Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Imunologia das Doenças Infecciosas., Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Imunologia das Doenças Infecciosas., Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivirus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Introduction: Guillain-Barré syndrome (GBS) in association with arboviruses, such as Zika, chikungunya, and dengue, has been previously documented; however, Miller-Fisher Syndrome (MFS) and other GBS subtypes are rarely reported. Methods: We identified a series of GBS and MFS cases that were followed during the Zika virus outbreak in Salvador, Brazil (2015-2016). Blood and CSF samples were collected for virus diagnosis. In addition, serological studies to verify previous arboviral infection and electromyography (EMG) were performed. Results: Of the 14 patients enrolled, 10 were diagnosed with GBS, including three GBS subtypes (two cases of bifacial weakness with paresthesia and one case of paraparetic GBS), and four as MFS. IgM antibodies against one or more of three arboviruses were present in 11 (78.6%) patients: anti-zika IgM positivity in eight (57%), anti-Chikungunya IgM in three (21%), and anti-Dengue in one (7%) individual. A single case was positive for both anti-Dengue IgM and anti-Chikungunya IgM, suggesting co-infection. EMG revealed an AIDP pattern in all nine patients analyzed. Conclusion: The current case series contributes to our knowledge on the clinical presentation of arbovirus-associated GBS and its subtypes, including MFS, and serves as an alert to clinicians and other healthcare professionals in regions affected by arbovirus outbreaks. We highlight the importance of recognizing arboviruses in diagnosing GBS and its subtypes.engFrontiers MediaSíndrome de Guillain-BarréSíndrome de Miller FisherZika vírusDengueChikungunyaGuillain-Barré syndromeMiller Fisher syndromeZika virusDengueChikungunyaSíndrome de Guillain-BarréSíndrome de Miller FisherZika virusDengueVírus ChikungunyaGuillain-Barré syndrome and Miller Fisher syndrome in association with an arboviral outbreak: a Brazilian case serieswinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57282/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRosario, M.S. Guillain-Barré Syndrome and Miller... 2022.pdfRosario, M.S. Guillain-Barré Syndrome and Miller... 2022.pdfapplication/pdf199821https://www.arca.fiocruz.br/bitstream/icict/57282/2/Rosario%2c%20M.S.%20Guillain-Barr%c3%a9%20Syndrome%20and%20Miller...%202022.pdffa40f0c2e1f4d836ecfbac1060fd5094MD52icict/572822023-03-15 14:32:52.92oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:52Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Guillain-Barré syndrome and Miller Fisher syndrome in association with an arboviral outbreak: a Brazilian case seriesw
title Guillain-Barré syndrome and Miller Fisher syndrome in association with an arboviral outbreak: a Brazilian case seriesw
spellingShingle Guillain-Barré syndrome and Miller Fisher syndrome in association with an arboviral outbreak: a Brazilian case seriesw
Rosário, Mateus Santana do
Síndrome de Guillain-Barré
Síndrome de Miller Fisher
Zika vírus
Dengue
Chikungunya
Guillain-Barré syndrome
Miller Fisher syndrome
Zika virus
Dengue
Chikungunya
Síndrome de Guillain-Barré
Síndrome de Miller Fisher
Zika virus
Dengue
Vírus Chikungunya
title_short Guillain-Barré syndrome and Miller Fisher syndrome in association with an arboviral outbreak: a Brazilian case seriesw
title_full Guillain-Barré syndrome and Miller Fisher syndrome in association with an arboviral outbreak: a Brazilian case seriesw
title_fullStr Guillain-Barré syndrome and Miller Fisher syndrome in association with an arboviral outbreak: a Brazilian case seriesw
title_full_unstemmed Guillain-Barré syndrome and Miller Fisher syndrome in association with an arboviral outbreak: a Brazilian case seriesw
title_sort Guillain-Barré syndrome and Miller Fisher syndrome in association with an arboviral outbreak: a Brazilian case seriesw
author Rosário, Mateus Santana do
author_facet Rosário, Mateus Santana do
Jesus, Pedro Antônio Pereira de
Farias, Daniel Santana
Novaes, Marco Antônio Caires
Francisco, Marcos Vinicius Lima Oliveira
Santos, Cleiton Silva
Moura, Daniel
Lima, Fernanda Washington de M.
Alcantara, Luiz Carlos Junior
Siqueira, Isadora Cristina de
author_role author
author2 Jesus, Pedro Antônio Pereira de
Farias, Daniel Santana
Novaes, Marco Antônio Caires
Francisco, Marcos Vinicius Lima Oliveira
Santos, Cleiton Silva
Moura, Daniel
Lima, Fernanda Washington de M.
Alcantara, Luiz Carlos Junior
Siqueira, Isadora Cristina de
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rosário, Mateus Santana do
Jesus, Pedro Antônio Pereira de
Farias, Daniel Santana
Novaes, Marco Antônio Caires
Francisco, Marcos Vinicius Lima Oliveira
Santos, Cleiton Silva
Moura, Daniel
Lima, Fernanda Washington de M.
Alcantara, Luiz Carlos Junior
Siqueira, Isadora Cristina de
dc.subject.other.en_US.fl_str_mv Síndrome de Guillain-Barré
Síndrome de Miller Fisher
Zika vírus
Dengue
Chikungunya
topic Síndrome de Guillain-Barré
Síndrome de Miller Fisher
Zika vírus
Dengue
Chikungunya
Guillain-Barré syndrome
Miller Fisher syndrome
Zika virus
Dengue
Chikungunya
Síndrome de Guillain-Barré
Síndrome de Miller Fisher
Zika virus
Dengue
Vírus Chikungunya
dc.subject.en.en_US.fl_str_mv Guillain-Barré syndrome
Miller Fisher syndrome
Zika virus
Dengue
Chikungunya
dc.subject.decs.en_US.fl_str_mv Síndrome de Guillain-Barré
Síndrome de Miller Fisher
Zika virus
Dengue
Vírus Chikungunya
description Ministério da Ciência, Tecnologia, Inovação (MCTI). Financiadora de Estudos e Projetos (FINEP). Fundo Nacional para o Desenvolvimento da Ciência e Tecnologia (FNDCT). Programa de Excelência em Pesquisa (PROEP). Instituto Gonçalo Moniz (IGM-Fiocruz)
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-03-08T16:36:19Z
dc.date.available.fl_str_mv 2023-03-08T16:36:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ROSÁRIO, Mateus Santana do et al. Guillain-Barré syndrome and Miller Fisher Syndrome in association with an arboviral outbreak: a Brazilian case series. Frontiers in Medicine, v. 9, p. 1-7, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57282
dc.identifier.issn.en_US.fl_str_mv 2296-858X
dc.identifier.doi.none.fl_str_mv 10.3389/fmed.2022.911175
identifier_str_mv ROSÁRIO, Mateus Santana do et al. Guillain-Barré syndrome and Miller Fisher Syndrome in association with an arboviral outbreak: a Brazilian case series. Frontiers in Medicine, v. 9, p. 1-7, 2022.
2296-858X
10.3389/fmed.2022.911175
url https://www.arca.fiocruz.br/handle/icict/57282
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/57282/1/license.txt
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