IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection

Detalhes bibliográficos
Autor(a) principal: Roffê, Ester
Data de Publicação: 2012
Outros Autores: Rothfuchs, Antonio Gigliotti, Santiago, Helton da Costa, Marino, Ana Paula Maia Peixoto, Gomes, Flavia Lima Ribeiro, Eckhaus, Michael, Antonelli, Lis Ribeiro do Valle, Murphy, Philip M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7844
Resumo: National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Molecular Immunology. Molecular Signaling Section. Bethesda, MD, USA
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spelling Roffê, EsterRothfuchs, Antonio GigliottiSantiago, Helton da CostaMarino, Ana Paula Maia PeixotoGomes, Flavia Lima RibeiroEckhaus, MichaelAntonelli, Lis Ribeiro do ValleMurphy, Philip M.2014-06-27T14:20:48Z2014-06-27T14:20:48Z2012ROFFE, Ester et al. IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection. The Journal of Immunology. 2012, vol.188, pp. 649-6600022-1767https://www.arca.fiocruz.br/handle/icict/7844engThe American Association of ImmunologistsIL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Molecular Immunology. Molecular Signaling Section. Bethesda, MD, USANational Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, MD, USA/Karolinska Institutet. Department of Microbiology. Tumor and Cell Biology. Stockholm, SwedenNational Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Helminth Immunology Section. Bethesda, MD, USANational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Molecular Immunology. Molecular Signaling Section. Bethesda, MD, USANational Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Intracellular Parasite Biology Section. Bethesda, MD, USANational Institute of Allergy and Infectious Diseases. O Office of the Director. ffice of Research Services. Division of Veterinary Resources. Bethesda, MD, USANational Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, MD, USA/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, BrazilNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Molecular Immunology. Molecular Signaling Section. Bethesda, MD, USAChagas' disease is a zoonosis prevalent in Latin America that is caused by the protozoan Trypanosoma cruzi. The immunopathogenesis of cardiomyopathy, the main clinical problem in Chagas' disease, has been extensively studied but is still poorly understood. In this study, we systematically compared clinical, microbiologic, pathologic, immunologic, and molecular parameters in two mouse models with opposite susceptibility to acute myocarditis caused by the myotropic Colombiana strain of T. cruzi: C3H/HeSnJ (100% mortality, uncontrolled parasitism) and C57BL/6J (<10% mortality, controlled parasitism). T. cruzi induced differential polarization of immunoregulatory cytokine mRNA expression in the hearts of C57BL/6J versus C3H/HeSnJ mice; however, most differences were small. The difference in IL-10 expression was exceptional (C57BL/6J 8.7-fold greater than C3H/HeSnJ). Consistent with this, hearts from infected C57BL/6J mice, but not C3H/HeSnJ mice, had a high frequency of total IL-10-producing CD8(+) T cells and both CD4(+) and CD8(+) subsets of IFN-γ(+)IL-10(+) double-producing T cells. Furthermore, T. cruzi infection of IL-10(-/-) C57BL/6J mice phenocopied fatal infection in wild-type C3H/HeSnJ mice with complete loss of parasite control. Adoptive transfer experiments indicated that T cells were a source of protective IL-10. Thus, in this system, IL-10 production by T cells promotes T. cruzi control and protection from fatal acute myocarditis.Chagas Disease/mortalityInterleukin-10/deficiencyInterleukin-10/physiologyMice, Inbred C3HMyocarditis/parasitologyMyocarditis/prevention & controlinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINAL. IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection.pdf. IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection.pdfapplication/pdf3474938https://www.arca.fiocruz.br/bitstream/icict/7844/1/.%20IL-10%20limits%20parasite%20burden%20and%20protects%20against%20fatal%20myocarditis%20in%20a%20mouse%20model%20of%20Trypanosoma%20cruzi%20infection.pdf16f33c5b8d642f9e9a7a13a95c91ca39MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7844/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXT. IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection.pdf.txt. 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dc.title.pt_BR.fl_str_mv IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection
title IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection
spellingShingle IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection
Roffê, Ester
Chagas Disease/mortality
Interleukin-10/deficiency
Interleukin-10/physiology
Mice, Inbred C3H
Myocarditis/parasitology
Myocarditis/prevention & control
title_short IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection
title_full IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection
title_fullStr IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection
title_full_unstemmed IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection
title_sort IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection
author Roffê, Ester
author_facet Roffê, Ester
Rothfuchs, Antonio Gigliotti
Santiago, Helton da Costa
Marino, Ana Paula Maia Peixoto
Gomes, Flavia Lima Ribeiro
Eckhaus, Michael
Antonelli, Lis Ribeiro do Valle
Murphy, Philip M.
author_role author
author2 Rothfuchs, Antonio Gigliotti
Santiago, Helton da Costa
Marino, Ana Paula Maia Peixoto
Gomes, Flavia Lima Ribeiro
Eckhaus, Michael
Antonelli, Lis Ribeiro do Valle
Murphy, Philip M.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Roffê, Ester
Rothfuchs, Antonio Gigliotti
Santiago, Helton da Costa
Marino, Ana Paula Maia Peixoto
Gomes, Flavia Lima Ribeiro
Eckhaus, Michael
Antonelli, Lis Ribeiro do Valle
Murphy, Philip M.
dc.subject.en.pt_BR.fl_str_mv Chagas Disease/mortality
Interleukin-10/deficiency
Interleukin-10/physiology
Mice, Inbred C3H
Myocarditis/parasitology
Myocarditis/prevention & control
topic Chagas Disease/mortality
Interleukin-10/deficiency
Interleukin-10/physiology
Mice, Inbred C3H
Myocarditis/parasitology
Myocarditis/prevention & control
description National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Molecular Immunology. Molecular Signaling Section. Bethesda, MD, USA
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-06-27T14:20:48Z
dc.date.available.fl_str_mv 2014-06-27T14:20:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ROFFE, Ester et al. IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection. The Journal of Immunology. 2012, vol.188, pp. 649-660
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7844
dc.identifier.issn.none.fl_str_mv 0022-1767
identifier_str_mv ROFFE, Ester et al. IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection. The Journal of Immunology. 2012, vol.188, pp. 649-660
0022-1767
url https://www.arca.fiocruz.br/handle/icict/7844
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv The American Association of Immunologists
publisher.none.fl_str_mv The American Association of Immunologists
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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