Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types

Detalhes bibliográficos
Autor(a) principal: Andrade, Sonia Gumes
Data de Publicação: 1985
Outros Autores: Magalhães, Juracy Barbosa, Pontes, Albélia Lima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14622
Resumo: Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Andrade, Sonia GumesMagalhães, Juracy BarbosaPontes, Albélia Lima2016-06-27T16:25:28Z2016-07-07T11:39:43Z2016-06-27T16:25:28Z2016-07-07T11:39:43Z1985ANDRADE, S. G.; MAGALHÃES, J. B.; PONTES, A. L. Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types. Bulletin ofthe World Health Organization, v. 63, n. 4, p. 721-726, 1985.0042-9686https://www.arca.fiocruz.br/handle/icict/14622engWorld Health OrganizationNifurtimoxBenzonidazoleTrypanosoma cruziXenodiagnósticoDoença de ChagasAnimalEvaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different typesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilA test was made of the susceptibility of 30 strains of Trypanosoma cruzi to chemotherapy with nifurtimox (Bay 2502) and benznidazole (Ro 7-1051). The strains had previously been classified as type I, II, or III according to their morphobiological and isoenzymic characteristics. Three type I strains, 14 type II strains, and 13 type III strains were studied. Mice were infected with 2 x IO6 bloodforms ofthese parasites and treatedfor 90 days with benznidazole or nifurtimox. All the surviving mice were submitted to parasitological tests (directparasitaemia, xenodiagnosis, inoculation in new-born mice, and haemoculture) andserological tests (indirect immunofluorescence). As the latter remainedpositive in about 80% of the parasitologically negative animals, the cure rates were based on the more reliable parasitological tests. Type I strains displayed high susceptibility, type II strains showed medium to high susceptibility, and type III strains were highly resistant to both drugs. Thefact that aparticular strain type, with its own level ofsusceptibility, usually predominates in a given geographical area may explain the contradictory results after chemotherapy from different endemic areas.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTAndrade SG Evaluation of....pdf.txtAndrade SG Evaluation of....pdf.txtExtracted texttext/plain24730https://www.arca.fiocruz.br/bitstream/icict/14622/4/Andrade%20SG%20Evaluation%20of....pdf.txte6440678b1edbdf238229745e2fe934cMD54LICENSElicense.txttext/plain2991https://www.arca.fiocruz.br/bitstream/icict/14622/2/license.txt5a560609d32a3863062d77ff32785d58MD52ORIGINALAndrade SG Evaluation of....pdfapplication/pdf836416https://www.arca.fiocruz.br/bitstream/icict/14622/3/Andrade%20SG%20Evaluation%20of....pdfd0875c69b61dc43a81121b3cb04c0257MD53icict/146222023-03-15 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dc.title.pt_BR.fl_str_mv Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types
title Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types
spellingShingle Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types
Andrade, Sonia Gumes
Nifurtimox
Benzonidazole
Trypanosoma cruzi
Xenodiagnóstico
Doença de Chagas
Animal
title_short Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types
title_full Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types
title_fullStr Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types
title_full_unstemmed Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types
title_sort Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types
author Andrade, Sonia Gumes
author_facet Andrade, Sonia Gumes
Magalhães, Juracy Barbosa
Pontes, Albélia Lima
author_role author
author2 Magalhães, Juracy Barbosa
Pontes, Albélia Lima
author2_role author
author
dc.contributor.author.fl_str_mv Andrade, Sonia Gumes
Magalhães, Juracy Barbosa
Pontes, Albélia Lima
dc.subject.other.pt_BR.fl_str_mv Nifurtimox
Benzonidazole
Trypanosoma cruzi
Xenodiagnóstico
Doença de Chagas
Animal
topic Nifurtimox
Benzonidazole
Trypanosoma cruzi
Xenodiagnóstico
Doença de Chagas
Animal
description Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1985
dc.date.issued.fl_str_mv 1985
dc.date.accessioned.fl_str_mv 2016-06-27T16:25:28Z
2016-07-07T11:39:43Z
dc.date.available.fl_str_mv 2016-06-27T16:25:28Z
2016-07-07T11:39:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, S. G.; MAGALHÃES, J. B.; PONTES, A. L. Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types. Bulletin ofthe World Health Organization, v. 63, n. 4, p. 721-726, 1985.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14622
dc.identifier.issn.pt_BR.fl_str_mv 0042-9686
identifier_str_mv ANDRADE, S. G.; MAGALHÃES, J. B.; PONTES, A. L. Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types. Bulletin ofthe World Health Organization, v. 63, n. 4, p. 721-726, 1985.
0042-9686
url https://www.arca.fiocruz.br/handle/icict/14622
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv World Health Organization
publisher.none.fl_str_mv World Health Organization
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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