Specific chemotherapy of Chagas disease: a comparison between the response in patients and experimental animals inoculated with the same strains

Detalhes bibliográficos
Autor(a) principal: Andrade, Sonia Gumes
Data de Publicação: 1992
Outros Autores: Rassi, Anis, Magalhaes, Juracy Barbosa, Ferriolli Ftiho, Francisco, Luquetti, Alexandro O
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14625
Resumo: Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Andrade, Sonia GumesRassi, AnisMagalhaes, Juracy BarbosaFerriolli Ftiho, FranciscoLuquetti, Alexandro O2016-06-27T17:25:43Z2016-07-07T11:39:43Z2016-06-27T17:25:43Z2016-07-07T11:39:43Z1992ANDRADE, S. G. et al. Specific chemotherapy of Chagas disease: a comparison between the response in patients and experimental animals inoculated with the same strains. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 86, p. 624-626, 1996.0035-9203https://www.arca.fiocruz.br/handle/icict/14625engOxford University PressDoença de chagasQuimioterapiaNifurtimoxBenzonidazoleXenodiagnósticoHumanosAnimalCamundongosBrasilSpecific chemotherapy of Chagas disease: a comparison between the response in patients and experimental animals inoculated with the same strainsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFederal University of Goiás. School of Medicine. Goiania, Goiania, BrasilFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUSP. Medical Faculty of Ribeirao Preto. Ribeirão Preto, São Paulo, SP. BrasilFederal University of Goiás. School of Medicine. Goiania, Goiania, BrasilEleven strains of Ttypanosoma cruzi were isolated from patients with Chagas disease in central Brazil by xenodiagnosis and inoculation into newborn mice. Biological characterization and isoenzyme analysis showed that 6 strains were type II (zymodeme 2) and 5 were type III (zymodeme 1). Patients were treated with benznidazole or benznidazole plus nifurtimox. Mice infected with each isolated strain were treated for comparison with the results obtained in the respective patient. Evaluation of cure of the patients was based on the indirect immunofluorescence test, complement fixation reaction and xenodiagnosis. For the mice, haemoculture, indirect immunofluorescence testing, xenodiagnosis and inoculation of blood into newborn mice were used. Tests were performed 3-6 months after the end of treatment. The cure rate was 66-100% in mice infected with type II strains and O-9% in those infected with type III strains. The correlation between treatment results in patients and mice was 8 1.8% (9 of 11 cases). Type II strains were more susceptible to treatment, in contrast to type III strains which yielded the majority of therapeutic failures.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTAndrade SG Specific chemotherapy....pdf.txtAndrade SG Specific chemotherapy....pdf.txtExtracted texttext/plain16698https://www.arca.fiocruz.br/bitstream/icict/14625/4/Andrade%20SG%20Specific%20chemotherapy....pdf.txtbd9b382fe336bd1feb5f17046dfc5ebdMD54ORIGINALAndrade SG Specific chemotherapy....pdfapplication/pdf355700https://www.arca.fiocruz.br/bitstream/icict/14625/2/Andrade%20SG%20Specific%20chemotherapy....pdf0dcc3387d102ca5b6a08a47967608532MD52LICENSElicense.txttext/plain2991https://www.arca.fiocruz.br/bitstream/icict/14625/3/license.txt5a560609d32a3863062d77ff32785d58MD53icict/146252023-03-15 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dc.title.pt_BR.fl_str_mv Specific chemotherapy of Chagas disease: a comparison between the response in patients and experimental animals inoculated with the same strains
title Specific chemotherapy of Chagas disease: a comparison between the response in patients and experimental animals inoculated with the same strains
spellingShingle Specific chemotherapy of Chagas disease: a comparison between the response in patients and experimental animals inoculated with the same strains
Andrade, Sonia Gumes
Doença de chagas
Quimioterapia
Nifurtimox
Benzonidazole
Xenodiagnóstico
Humanos
Animal
Camundongos
Brasil
title_short Specific chemotherapy of Chagas disease: a comparison between the response in patients and experimental animals inoculated with the same strains
title_full Specific chemotherapy of Chagas disease: a comparison between the response in patients and experimental animals inoculated with the same strains
title_fullStr Specific chemotherapy of Chagas disease: a comparison between the response in patients and experimental animals inoculated with the same strains
title_full_unstemmed Specific chemotherapy of Chagas disease: a comparison between the response in patients and experimental animals inoculated with the same strains
title_sort Specific chemotherapy of Chagas disease: a comparison between the response in patients and experimental animals inoculated with the same strains
author Andrade, Sonia Gumes
author_facet Andrade, Sonia Gumes
Rassi, Anis
Magalhaes, Juracy Barbosa
Ferriolli Ftiho, Francisco
Luquetti, Alexandro O
author_role author
author2 Rassi, Anis
Magalhaes, Juracy Barbosa
Ferriolli Ftiho, Francisco
Luquetti, Alexandro O
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Sonia Gumes
Rassi, Anis
Magalhaes, Juracy Barbosa
Ferriolli Ftiho, Francisco
Luquetti, Alexandro O
dc.subject.other.pt_BR.fl_str_mv Doença de chagas
Quimioterapia
Nifurtimox
Benzonidazole
Xenodiagnóstico
Humanos
Animal
Camundongos
Brasil
topic Doença de chagas
Quimioterapia
Nifurtimox
Benzonidazole
Xenodiagnóstico
Humanos
Animal
Camundongos
Brasil
description Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1992
dc.date.issued.fl_str_mv 1992
dc.date.accessioned.fl_str_mv 2016-06-27T17:25:43Z
2016-07-07T11:39:43Z
dc.date.available.fl_str_mv 2016-06-27T17:25:43Z
2016-07-07T11:39:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, S. G. et al. Specific chemotherapy of Chagas disease: a comparison between the response in patients and experimental animals inoculated with the same strains. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 86, p. 624-626, 1996.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14625
dc.identifier.issn.pt_BR.fl_str_mv 0035-9203
identifier_str_mv ANDRADE, S. G. et al. Specific chemotherapy of Chagas disease: a comparison between the response in patients and experimental animals inoculated with the same strains. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 86, p. 624-626, 1996.
0035-9203
url https://www.arca.fiocruz.br/handle/icict/14625
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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