Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion

Detalhes bibliográficos
Autor(a) principal: Spencer, Lisa A.
Data de Publicação: 2006
Outros Autores: Melo, Rossana C. N., Perez, Sandra A. C., Bafford, Staci P., Dvorak, Ann M., Weller, Peter F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/39713
Resumo: Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Medicine. Boston, MA, USA.
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spelling Spencer, Lisa A.Melo, Rossana C. N.Perez, Sandra A. C.Bafford, Staci P.Dvorak, Ann M.Weller, Peter F.2020-02-04T14:56:42Z2020-02-04T14:56:42Z2006SPENCER, Lisa A. et al. Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion. Proceedings of the National Academy of Sciences (PNAS), v. 103, n. 9, p. 3333-3338, Feb. 2006.0027-8424https://www.arca.fiocruz.br/handle/icict/3971310.1073/pnas.05089461031091-6490engNational Academy of SciencesReceptor intracelular de citocinasTransporte vesicularTráfico intracelular de citocinasDegranulação fragmentadaIntracellular cytokine receptorIntracellular cytokine traffickingPiecemeal degranulationVesicular transportCytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHarvard Medical School. Beth Israel Deaconess Medical Center. Department of Medicine. Boston, MA, USA.Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Medicine. Boston, MA, USA / Universidade Federal de Juiz de Fora. Departamento de Biologia. Juiz de Fora, MG, Brasil.Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Medicine. Boston, MA, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Medicine. Boston, MA, USA.Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Pathology. Boston, MA, USA.Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Medicine. Boston, MA, USA.Although leukocytes of the innate immune system, including eosinophils, contain within their granules preformed stores of cytokines available for selective and rapid release, little is known about the mechanisms governing the mobilization and secretion of these cytokines. Here we show that a cytokine receptor, the IL-4 receptor alpha chain, mediates eotaxin-stimulated mobilization of preformed IL-4 from eosinophil granules into secretory vesicles. Eosinophils contain substantial intracellular quantities of several granule- and vesicle-associated cytokine receptors, including IL-4, IL-6, and IL-13 receptors as well as CCR3. Both IL-4 and IL-4 receptor alpha chain colocalized in eosinophil granules; and after eotaxin-stimulation, IL-4 receptor alpha chain, bearing bound IL-4, was mobilized into secretory vesicles. These findings indicate that intracellular cytokine receptors within secretory vesicles transport their cognate cytokines requisite for the secretion of cytokines preformed in innate immune leukocytes.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/39713/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSandraAC_Peres_etal_IOC_2006.pdfSandraAC_Peres_etal_IOC_2006.pdfapplication/pdf979874https://www.arca.fiocruz.br/bitstream/icict/39713/2/SandraAC_Peres_etal_IOC_2006.pdf30e670881427cbf6d003795deb73fe33MD52TEXTSandraAC_Peres_etal_IOC_2006.pdf.txtSandraAC_Peres_etal_IOC_2006.pdf.txtExtracted texttext/plain42768https://www.arca.fiocruz.br/bitstream/icict/39713/3/SandraAC_Peres_etal_IOC_2006.pdf.txtdcbc092673cad3f4497617487b44e33aMD53icict/397132020-02-07 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dc.title.pt_BR.fl_str_mv Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion
title Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion
spellingShingle Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion
Spencer, Lisa A.
Receptor intracelular de citocinas
Transporte vesicular
Tráfico intracelular de citocinas
Degranulação fragmentada
Intracellular cytokine receptor
Intracellular cytokine trafficking
Piecemeal degranulation
Vesicular transport
title_short Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion
title_full Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion
title_fullStr Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion
title_full_unstemmed Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion
title_sort Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion
author Spencer, Lisa A.
author_facet Spencer, Lisa A.
Melo, Rossana C. N.
Perez, Sandra A. C.
Bafford, Staci P.
Dvorak, Ann M.
Weller, Peter F.
author_role author
author2 Melo, Rossana C. N.
Perez, Sandra A. C.
Bafford, Staci P.
Dvorak, Ann M.
Weller, Peter F.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Spencer, Lisa A.
Melo, Rossana C. N.
Perez, Sandra A. C.
Bafford, Staci P.
Dvorak, Ann M.
Weller, Peter F.
dc.subject.other.pt_BR.fl_str_mv Receptor intracelular de citocinas
Transporte vesicular
Tráfico intracelular de citocinas
Degranulação fragmentada
topic Receptor intracelular de citocinas
Transporte vesicular
Tráfico intracelular de citocinas
Degranulação fragmentada
Intracellular cytokine receptor
Intracellular cytokine trafficking
Piecemeal degranulation
Vesicular transport
dc.subject.en.pt_BR.fl_str_mv Intracellular cytokine receptor
Intracellular cytokine trafficking
Piecemeal degranulation
Vesicular transport
description Harvard Medical School. Beth Israel Deaconess Medical Center. Department of Medicine. Boston, MA, USA.
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2020-02-04T14:56:42Z
dc.date.available.fl_str_mv 2020-02-04T14:56:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SPENCER, Lisa A. et al. Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion. Proceedings of the National Academy of Sciences (PNAS), v. 103, n. 9, p. 3333-3338, Feb. 2006.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/39713
dc.identifier.issn.pt_BR.fl_str_mv 0027-8424
dc.identifier.doi.none.fl_str_mv 10.1073/pnas.0508946103
dc.identifier.eissn.none.fl_str_mv 1091-6490
identifier_str_mv SPENCER, Lisa A. et al. Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion. Proceedings of the National Academy of Sciences (PNAS), v. 103, n. 9, p. 3333-3338, Feb. 2006.
0027-8424
10.1073/pnas.0508946103
1091-6490
url https://www.arca.fiocruz.br/handle/icict/39713
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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