Mechanisms of eosinophil cytokine release

Detalhes bibliográficos
Autor(a) principal: Melo, Christianne Bandeira
Data de Publicação: 2005
Outros Autores: Weller, Peter F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44567
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
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spelling Melo, Christianne BandeiraWeller, Peter F.2020-11-20T20:32:39Z2020-11-20T20:32:39Z2005MELO, Cristianne Bandeira; WELLER, Peter. Mechanisms of eosinophil cytokine release. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Suppl.1, p. 73-81, 2005.0074-0276https://www.arca.fiocruz.br/handle/icict/4456710.1590/S0074-027620050009000131678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.DegranulaçãoCitocinasEosinófilosEosinophilsCytokinesDegranulationMechanisms of eosinophil cytokine releaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Harvard Medical School. Department of Medicine. Harvard Thorndike Laboratories, Charles A. Dana Research Institute, Beth Israel Deaconess Medical Center. Boston, MA, USAHuman eosinophils have been demonstrated to contain a multitude of cytokines and chemokines that exist preformed within these cells. This content of pre-formed cytokines, with diverse potential biologic activities, provides eosinophils with capabilities distinct from most other leukocytes. The localization of pre-formed cytokines within eosinophils is both within specific granules and associated with substantial numbers of morphologically distinct cytoplasmic vesicles. Stimulation for release of specific cytokines, such as IL-4, leads to a regulated signal transduction cascade, which is dependent on the formation of leukotriene C4 within eosinophils where it acts as an intracrine mediator. IL-4 release occurs selectively and is by means of vesicular transport. The capabilities of eosinophils not only to rapidly release pre-formed cytokines but also to differentially regulate which cytokines are released endow eosinophils with distinct abilities in innate and acquired immunity.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44567/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALChristianeBMeloPeterWeller_IOC_2005.pdfChristianeBMeloPeterWeller_IOC_2005.pdfapplication/pdf89669https://www.arca.fiocruz.br/bitstream/icict/44567/2/ChristianeBMeloPeterWeller_IOC_2005.pdfb6eb0c41c39bcd201b5d027b7cef9bb5MD52TEXTChristianeBMeloPeterWeller_IOC_2005.pdf.txtChristianeBMeloPeterWeller_IOC_2005.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Mechanisms of eosinophil cytokine release
title Mechanisms of eosinophil cytokine release
spellingShingle Mechanisms of eosinophil cytokine release
Melo, Christianne Bandeira
Degranulação
Citocinas
Eosinófilos
Eosinophils
Cytokines
Degranulation
title_short Mechanisms of eosinophil cytokine release
title_full Mechanisms of eosinophil cytokine release
title_fullStr Mechanisms of eosinophil cytokine release
title_full_unstemmed Mechanisms of eosinophil cytokine release
title_sort Mechanisms of eosinophil cytokine release
author Melo, Christianne Bandeira
author_facet Melo, Christianne Bandeira
Weller, Peter F.
author_role author
author2 Weller, Peter F.
author2_role author
dc.contributor.author.fl_str_mv Melo, Christianne Bandeira
Weller, Peter F.
dc.subject.other.pt_BR.fl_str_mv Degranulação
Citocinas
Eosinófilos
topic Degranulação
Citocinas
Eosinófilos
Eosinophils
Cytokines
Degranulation
dc.subject.en.pt_BR.fl_str_mv Eosinophils
Cytokines
Degranulation
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2020-11-20T20:32:39Z
dc.date.available.fl_str_mv 2020-11-20T20:32:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MELO, Cristianne Bandeira; WELLER, Peter. Mechanisms of eosinophil cytokine release. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Suppl.1, p. 73-81, 2005.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44567
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762005000900013
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv MELO, Cristianne Bandeira; WELLER, Peter. Mechanisms of eosinophil cytokine release. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Suppl.1, p. 73-81, 2005.
0074-0276
10.1590/S0074-02762005000900013
1678-8060
url https://www.arca.fiocruz.br/handle/icict/44567
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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