Transplantation of bone marrow mononuclear cells reduces mortality and improves renal function on mercury-induced kidney injury in
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/9880 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Marques, Franciane SantosSilva, Joselli SantosCouto, Ricardo DavidBarreto Junior, Elton Pereira de SáSantos, Ricardo Ribeiro dosdosSantos, Washington Luis ConradoSoares, Milena Botelho Pereira2015-04-06T16:29:32Z2015-04-06T16:29:32Z2013MARQUES, F. S. et al. Transplantation of bone marrow mononuclear cells reduces mortality and improves renal function on mercury-induced kidney injury in mice. Renal Failure, v. 35, n. 5, p. 776–781, 2013.1525-604910.3109/0886022X.2013.780660https://www.arca.fiocruz.br/handle/icict/9880engInforma HealthcareTransplantation of bone marrow mononuclear cells reduces mortality and improves renal function on mercury-induced kidney injury ininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Bioquímica Clínica. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, BrasilOBJECTIVE: Recent studies have demonstrated the therapeutic effects of bone marrow-derived cells in tissue regeneration. The aim of this study was to investigate the effects of bone marrow mononuclear cell (BMMC) transplantation in a mouse model of acute renal failure (ARF) induced by mercuric chloride. METHODS: BMMC was isolated from male BALB/c mice and injected into female mice treated with a lethal dose (LD90) of mercuric chloride. Survival rate, histopathological analysis, and assessment of urea, creatinine, sodium, potassium, and mercury levels were carried out. RESULTS: Cellular therapy with BMMC significantly reduced the mortality induced by mercuric chloride (p < 0.05). This finding correlated with a decrease in serum levels of urea (p = 0.04) and potassium (p < 0.01). However, no differences in renal morphology were observed when BMMC-treated and control group were compared. CONCLUSION: Transplanted BMMC improve renal function and reduce mortality and, therefore, may represent a new therapeutic alternative to treat ARF.Mercuric chlorideAcute renal failureBone marrow mononuclear cellsCell therapyLesão Renal Aguda/terapiaTransplante de Medula ÓsseaMonócitos/transplanteLesão Renal Aguda/induzido quimicamenteAnimaisModelos Animais de DoençasFemininoMasculinoCloreto de MercúrioCamundongosCamundongos Endogâmicos BALB Cinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/9880/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALMarques FS Transplantation....pdfMarques FS Transplantation....pdfapplication/pdf819845https://www.arca.fiocruz.br/bitstream/icict/9880/2/Marques%20FS%20Transplantation....pdfe5e2bbab42d5b5f41e08df5727a6a940MD52TEXTMarques FS Transplantation....pdf.txtMarques FS Transplantation....pdf.txtExtracted texttext/plain23054https://www.arca.fiocruz.br/bitstream/icict/9880/3/Marques%20FS%20Transplantation....pdf.txt30b9d477ad73271ac9d0e9fb6a92d39cMD53icict/98802023-03-15 14:33:20.448oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:20Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Transplantation of bone marrow mononuclear cells reduces mortality and improves renal function on mercury-induced kidney injury in |
| title |
Transplantation of bone marrow mononuclear cells reduces mortality and improves renal function on mercury-induced kidney injury in |
| spellingShingle |
Transplantation of bone marrow mononuclear cells reduces mortality and improves renal function on mercury-induced kidney injury in Marques, Franciane Santos Mercuric chloride Acute renal failure Bone marrow mononuclear cells Cell therapy Lesão Renal Aguda/terapia Transplante de Medula Óssea Monócitos/transplante Lesão Renal Aguda/induzido quimicamente Animais Modelos Animais de Doenças Feminino Masculino Cloreto de Mercúrio Camundongos Camundongos Endogâmicos BALB C |
| title_short |
Transplantation of bone marrow mononuclear cells reduces mortality and improves renal function on mercury-induced kidney injury in |
| title_full |
Transplantation of bone marrow mononuclear cells reduces mortality and improves renal function on mercury-induced kidney injury in |
| title_fullStr |
Transplantation of bone marrow mononuclear cells reduces mortality and improves renal function on mercury-induced kidney injury in |
| title_full_unstemmed |
Transplantation of bone marrow mononuclear cells reduces mortality and improves renal function on mercury-induced kidney injury in |
| title_sort |
Transplantation of bone marrow mononuclear cells reduces mortality and improves renal function on mercury-induced kidney injury in |
| author |
Marques, Franciane Santos |
| author_facet |
Marques, Franciane Santos Silva, Joselli Santos Couto, Ricardo David Barreto Junior, Elton Pereira de Sá Santos, Ricardo Ribeiro dos dosSantos, Washington Luis Conrado Soares, Milena Botelho Pereira |
| author_role |
author |
| author2 |
Silva, Joselli Santos Couto, Ricardo David Barreto Junior, Elton Pereira de Sá Santos, Ricardo Ribeiro dos dosSantos, Washington Luis Conrado Soares, Milena Botelho Pereira |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Marques, Franciane Santos Silva, Joselli Santos Couto, Ricardo David Barreto Junior, Elton Pereira de Sá Santos, Ricardo Ribeiro dos dosSantos, Washington Luis Conrado Soares, Milena Botelho Pereira |
| dc.subject.en.pt_BR.fl_str_mv |
Mercuric chloride Acute renal failure Bone marrow mononuclear cells Cell therapy |
| topic |
Mercuric chloride Acute renal failure Bone marrow mononuclear cells Cell therapy Lesão Renal Aguda/terapia Transplante de Medula Óssea Monócitos/transplante Lesão Renal Aguda/induzido quimicamente Animais Modelos Animais de Doenças Feminino Masculino Cloreto de Mercúrio Camundongos Camundongos Endogâmicos BALB C |
| dc.subject.decs.pt_BR.fl_str_mv |
Lesão Renal Aguda/terapia Transplante de Medula Óssea Monócitos/transplante Lesão Renal Aguda/induzido quimicamente Animais Modelos Animais de Doenças Feminino Masculino Cloreto de Mercúrio Camundongos Camundongos Endogâmicos BALB C |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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2013 |
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2013 |
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2015-04-06T16:29:32Z |
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2015-04-06T16:29:32Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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MARQUES, F. S. et al. Transplantation of bone marrow mononuclear cells reduces mortality and improves renal function on mercury-induced kidney injury in mice. Renal Failure, v. 35, n. 5, p. 776–781, 2013. |
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https://www.arca.fiocruz.br/handle/icict/9880 |
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1525-6049 10.3109/0886022X.2013.780660 |
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MARQUES, F. S. et al. Transplantation of bone marrow mononuclear cells reduces mortality and improves renal function on mercury-induced kidney injury in mice. Renal Failure, v. 35, n. 5, p. 776–781, 2013. 1525-6049 10.3109/0886022X.2013.780660 |
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Informa Healthcare |
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Informa Healthcare |
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